Detailed information for compound 774214

Basic information

Technical information
  • TDR Targets ID: 774214
  • Name: N-(2,5-dichlorophenyl)-2-ethylpyrazole-3-carb oxamide
  • MW: 284.141 | Formula: C12H11Cl2N3O
  • H donors: 1 H acceptors: 2 LogP: 2.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1nccc1C(=O)Nc1cc(Cl)ccc1Cl
  • InChi: 1S/C12H11Cl2N3O/c1-2-17-11(5-6-15-17)12(18)16-10-7-8(13)3-4-9(10)14/h3-7H,2H2,1H3,(H,16,18)
  • InChiKey: AURNFQIXULWEJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dichlorophenyl)-2-ethyl-pyrazole-3-carboxamide
  • N-(2,5-dichlorophenyl)-2-ethyl-3-pyrazolecarboxamide
  • IDI1_024087
  • N-(2,5-dichlorophenyl)-1-ethyl-1H-pyrazole-5-carboxamide
  • SMR000020415
  • ChemDiv3_006177
  • MLS000085480

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2087 0.4684
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2087 0.4684
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.1436 1
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0409 0.1083
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.1436 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0409 0.0918
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4457 0.4457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2087 0.4684
Schistosoma mansoni inositol monophosphatase 0.0038 0.1436 0.3223
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0284 0.0638
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0409 0.0918
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0284 0.0284
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4457 0.4457
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0409 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.1436 1
Schistosoma mansoni ap endonuclease 0.0023 0.0284 0.0638
Echinococcus multilocularis dnaJ subfamily C 6 0.0059 0.3123 0.7008
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0409 1
Schistosoma mansoni hypothetical protein 0.0041 0.1715 0.3848
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0284 0.0284
Brugia malayi Inositol-1 0.0038 0.1436 0.1436
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.1436 0.3223
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4457 1
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.1131 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4457 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0409 0.0918
Loa Loa (eye worm) inositol-1 0.0038 0.1436 0.1436
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0409 0.1083
Echinococcus granulosus tar DNA binding protein 0.0076 0.4457 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.2087 0.2087
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0409 0.1083
Loa Loa (eye worm) hypothetical protein 0.006 0.3193 0.3193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.3193 0.3193
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0409 0.0918
Trichomonas vaginalis protein kinase inhibitor, putative 0.0059 0.3123 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1436 1
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0409 0.1083
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.1436 1
Brugia malayi RNA binding protein 0.0076 0.4457 0.4457
Schistosoma mansoni inositol monophosphatase 0.0038 0.1436 0.3223
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4457 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.1436 0.4058
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0409 0.0409
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1436 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.3193 0.3193
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4457 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.0059 0.3123 0.3123
Schistosoma mansoni hypothetical protein 0.0059 0.3123 0.7008
Onchocerca volvulus Huntingtin homolog 0.0148 1 0.5
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0409 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0409 0.0918
Brugia malayi DnaJ domain containing protein 0.0059 0.3123 0.3123
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4457 0.4457
Trichomonas vaginalis chaperonin, putative 0.0024 0.0409 0.0439
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1436 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0284 0.0638
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4457 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.2087 0.2087
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.1131 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.3193 0.3193
Schistosoma mansoni ap endonuclease 0.0023 0.0284 0.0638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2087 0.4684
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0284 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1715 0.1715
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Echinococcus granulosus dnaJ subfamily C 6 0.0059 0.3123 0.7008
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0409 0.1083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.1436 0.4058
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.1436 0.3223
Brugia malayi TAR-binding protein 0.0076 0.4457 0.4457
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1436 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2087 0.4684
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.1436 0.4058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2087 0.4684
Loa Loa (eye worm) hypothetical protein 0.0041 0.1715 0.1715
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0409 0.0409
Loa Loa (eye worm) RNA binding protein 0.0076 0.4457 0.4457
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4457 1
Onchocerca volvulus Huntingtin homolog 0.0148 1 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2087 0.4684
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0409 0.0439

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0794 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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