Detailed information for compound 774310

Basic information

Technical information
  • TDR Targets ID: 774310
  • Name: 4'-amino-6'-(4-methylphenyl)spiro[1,3-dioxola ne-2,2'-3-azabicyclo[3.1.0]hex-3-ene]-1',5'-d icarbonitrile
  • MW: 294.308 | Formula: C16H14N4O2
  • H donors: 1 H acceptors: 2 LogP: 0.08 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC12C(C2(C#N)C(=NC21OCCO2)N)c1ccc(cc1)C
  • InChi: 1S/C16H14N4O2/c1-10-2-4-11(5-3-10)12-14(8-17)13(19)20-16(15(12,14)9-18)21-6-7-22-16/h2-5,12H,6-7H2,1H3,(H2,19,20)
  • InChiKey: BLJDFWKFWRQMHI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0158 0.0122
Mycobacterium tuberculosis Probable reductase 0.0224 0.0918 0.8879
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0028 0.0138
Brugia malayi jmjC domain containing protein 0.0038 0.0061 0.0305
Leishmania major trypanothione reductase 0.0098 0.0338 0.0333
Plasmodium falciparum pyruvate kinase 0.0033 0.0037 0.0754
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.2195 1 1
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0061 0.0056
Schistosoma mansoni pyruvate kinase 0.0033 0.0037 0.0009
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0042 0.0005
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0061 0.0034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0154 0.0149
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0061 0.0034
Leishmania major hypothetical protein, conserved 0.0211 0.0855 0.085
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0158 0.0131
Brugia malayi Bromodomain containing protein 0.0119 0.0431 0.215
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0224 0.0918 0.8879
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0095 0.0476
Brugia malayi Probable ATP-dependent helicase DHX35 0.0037 0.0053 0.0264
Brugia malayi hypothetical protein 0.015 0.0574 0.2859
Loa Loa (eye worm) hypothetical protein 0.046 0.2006 1
Onchocerca volvulus 0.0094 0.0317 0.1455
Loa Loa (eye worm) hypothetical protein 0.0037 0.0053 0.0129
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0061 0.1324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0042 0.0014
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.2195 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0075 0.0239
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0028 0.0023
Plasmodium falciparum phd finger protein, putative 0.0119 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0061 0.0169
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0042 0.0005
Brugia malayi jmjC domain containing protein 0.0389 0.1675 0.8348
Trypanosoma brucei trypanothione reductase 0.0098 0.0338 0.0333
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0037 0.0046
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.0617 1
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0855 0.0821
Brugia malayi PHD-finger family protein 0.0039 0.0063 0.0316
Giardia lamblia PHD finger protein 15 0.0119 0.0431 0.0396
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.176 0.8755
Treponema pallidum NADH oxidase 0.0034 0.0042 0.0269
Brugia malayi PHD-finger family protein 0.0119 0.0431 0.215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Echinococcus multilocularis jumonji domain containing protein 0.0165 0.0645 0.0641
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.2195 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0028 0.0138
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0042 0.0037
Echinococcus multilocularis pyruvate kinase 0.0033 0.0037 0.0032
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.2195 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0042 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0095 0.0068
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.1384 0.1352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0249 0.1033 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0028 0.0138
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0042 0.0868
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0037 0.0754
Entamoeba histolytica hypothetical protein, conserved 0.2195 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0144 0.0546 0.052
Brugia malayi Pre-SET motif family protein 0.0058 0.0154 0.0766
Loa Loa (eye worm) glutathione reductase 0.0098 0.0338 0.1567
Brugia malayi MAP kinase sur-1 0.0059 0.0158 0.0788
Echinococcus granulosus phd:f box containing protein 0.0038 0.0061 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1586 0.7191 0.719
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0158 0.0154
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0063 0.0059
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0311 0.1551
Echinococcus multilocularis pyruvate kinase 0.0033 0.0037 0.0032
Chlamydia trachomatis pyruvate kinase 0.0033 0.0037 0.868
Onchocerca volvulus 0.0093 0.0311 0.1424
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0063 0.1376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0095 0.0091
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0028 0.0138
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.2195 1 1
Plasmodium falciparum glutathione reductase 0.0098 0.0338 0.7807
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0338 0.0333
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.0431 1
Plasmodium vivax hypothetical protein, conserved 0.0119 0.0431 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Brugia malayi nuclear hormone receptor 0.0031 0.0028 0.0138
Leishmania major pyruvate kinase 0.0033 0.0037 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0389 0.1675 0.1671
Schistosoma mansoni hypothetical protein 0.0119 0.0431 0.0405
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0338 0.7807
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0311 0.0307
Loa Loa (eye worm) DEAH box polypeptide 35 0.0037 0.0053 0.0129
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0028 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0042 0.0037
Echinococcus multilocularis survival motor neuron protein 1 0.046 0.2006 0.2002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0042 0.0005
Loa Loa (eye worm) hypothetical protein 0.015 0.0574 0.276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0005
Plasmodium vivax SET domain protein, putative 0.0058 0.0154 0.3493
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0042 0.0037
Schistosoma mansoni pyruvate kinase 0.0033 0.0037 0.0009
Brugia malayi hypothetical protein 0.046 0.2006 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0154 0.0126
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0061 0.0024
Brugia malayi steroid hormone receptor 0.0031 0.0028 0.0138
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0037
Brugia malayi glutathione reductase 0.0098 0.0338 0.1683
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0042 0.0868
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0158 0.0131
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0136 0.0109
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0311 0.0284
Loa Loa (eye worm) hypothetical protein 0.0093 0.0311 0.1433
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0028 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0338 0.0302
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0158 0.0122
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0061 0.0057
Schistosoma mansoni hypothetical protein 0.2195 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0158 0.0122
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0061 0.0024
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0042 0.0037
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0063 0.1376
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.2195 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0154 0.3493
Brugia malayi ecdysteroid receptor 0.0031 0.0028 0.0138
Brugia malayi Thioredoxin reductase 0.0098 0.0338 0.1683
Echinococcus granulosus peregrin 0.0119 0.0431 0.0405
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0042 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.2195 1 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0042 0.036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0028 0.0138
Loa Loa (eye worm) hypothetical protein 0.0203 0.0822 0.4013
Trichomonas vaginalis set domain proteins, putative 0.0463 0.2019 0.199
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0158 0.0154
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0158 0.0131
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0061 0.0034
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0158 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0028 0.0138
Brugia malayi Pre-SET motif family protein 0.0407 0.176 0.8772
Echinococcus multilocularis lysine specific demethylase 5A 0.0144 0.0546 0.0542
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0249 0.1033 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0061 0.0034
Loa Loa (eye worm) hypothetical protein 0.0119 0.0431 0.204
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0389 0.1675 0.1652
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0028 0.0138
Plasmodium falciparum glutathione reductase 0.0034 0.0042 0.0868
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0042 1
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0073 0.0365
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0061 0.0034
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.0617 0.5953
Leishmania major hypothetical protein, conserved 0.0038 0.0061 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Plasmodium falciparum thioredoxin reductase 0.0034 0.0042 0.0868
Schistosoma mansoni jumonji/arid domain-containing protein 0.0144 0.0546 0.052
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0042 0.0005
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0061 0.0056
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0042 0.0005
Schistosoma mansoni hypothetical protein 0.0039 0.0063 0.0036
Leishmania major pyruvate kinase 0.0033 0.0037 0.0032
Onchocerca volvulus Alhambra homolog 0.0119 0.0431 0.2027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0028 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0224 0.0918 0.8879
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0042 0.0868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0095 0.0068
Plasmodium vivax glutathione reductase, putative 0.0098 0.0338 0.7807
Echinococcus multilocularis PHD finger protein rhinoceros 0.0119 0.0431 0.0427
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0037 0.0032
Echinococcus granulosus PHD finger protein rhinoceros 0.0119 0.0431 0.0405
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.2195 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0037 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0028 0.0138
Brugia malayi jmjC domain containing protein 0.0038 0.0061 0.0305
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0042 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0181
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0042 0.0605
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0042 0.0868
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0028 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0158 0.0154
Brugia malayi Cytochrome P450 family protein 0.0041 0.0075 0.0373
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0158 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0095 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0154 0.0126
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0061 0.1324
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0028 0.0138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0028 0.0138
Giardia lamblia Rrm3p helicase 0.2195 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0158 0.066
Brugia malayi jmjC domain containing protein 0.0038 0.0061 0.0305
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0042 0.0037
Plasmodium vivax JmjC domain containing protein 0.0038 0.0061 0.1324
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0028 0.0023
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0063 0.1376
Onchocerca volvulus 0.0058 0.0154 0.0633
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0037 0.0754
Mycobacterium tuberculosis Probable dehydrogenase 0.0224 0.0918 0.8879
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0317 0.1582
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0037 0.0183
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0037 0.0313
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.1384 0.138
Brugia malayi AF-10 protein 0.0039 0.0063 0.0316
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0037 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.2195 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0063 0.1376
Entamoeba histolytica DNA repair and recombination protein, putative 0.2195 1 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0311 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0855 0.0821
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0042 0.0868
Loa Loa (eye worm) jmjC domain-containing protein 0.0144 0.0546 0.2621
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0136 0.0132
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0042 0.0605
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0063 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0095 0.0068
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0061 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0061 0.0169
Schistosoma mansoni hypothetical protein 0.0094 0.0317 0.0291
Echinococcus granulosus lysine specific demethylase 5A 0.0144 0.0546 0.052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0042 0.0605
Schistosoma mansoni jumonji domain containing protein 0.0309 0.1307 0.1283
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.1013 0.4981
Brugia malayi jmjC domain containing protein 0.0038 0.0061 0.0305
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0154 0.0149
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0338 0.0311
Loa Loa (eye worm) hypothetical protein 0.0058 0.0154 0.0637
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0158 0.0122
Toxoplasma gondii thioredoxin reductase 0.0098 0.0338 0.7807
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0338 0.1567
Loa Loa (eye worm) PHD-finger family protein 0.0119 0.0431 0.204
Brugia malayi nuclear receptor NHR-88 0.0031 0.0028 0.0138
Plasmodium falciparum JmjC domain-containing protein, putative 0.0038 0.0061 0.1324
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0061 0.0056
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0042 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.0431 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0249 0.1033 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0037 0.0183
Echinococcus granulosus pyruvate kinase 0.0033 0.0037 0.0009
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.1384 1
Onchocerca volvulus 0.0463 0.2019 1
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0028 0.0023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0158 0.0122
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0037 0.0046
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0224 0.0918 0.8879
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0028 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0211 0.0855 0.085
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.1384 0.138
Echinococcus multilocularis peregrin 0.0119 0.0431 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0095 0.0091
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.0617 0.5953
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0042 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0028 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0154 0.0126
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0061 0.0034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0338 0.3238
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0061 0.0056
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0224 0.0918 0.8879
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0158 0.3599
Echinococcus granulosus pyruvate kinase 0.0033 0.0037 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0037 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0028 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0042 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0028 0.0023
Plasmodium falciparum thioredoxin reductase 0.0098 0.0338 0.7807
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0154 0.0126
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0144 0.0116
Loa Loa (eye worm) hypothetical protein 0.0038 0.0061 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0005
Schistosoma mansoni survival motor neuron protein 0.0094 0.0317 0.0291
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0061 0.0169
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0037 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0028 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0154 0.0126
Schistosoma mansoni lipoxygenase 0.0055 0.0136 0.0109
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0095 0.0343
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0061 0.0034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0028 0.0023
Mycobacterium tuberculosis Probable oxidoreductase 0.0249 0.1033 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0061 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0042 0.0005
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0037 0.0525
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0119 0.0431 0.0405
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0042 0.0868
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0224 0.0918 0.8879
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0073 0.0046
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0158 0.0122
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0061 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0028 0.0023
Trypanosoma brucei protein kinase, putative 0.0059 0.0158 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1384 0.1352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0028 0.0023
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0061 0.0034
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0158 0.0122
Brugia malayi jmjC domain containing protein 0.0144 0.0546 0.2723
Echinococcus granulosus survival motor neuron protein 1 0.046 0.2006 0.1984
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0158 0.0122
Echinococcus granulosus jumonji domain containing protein 0.0165 0.0645 0.0619
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0158 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0095 0.0068
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0037 0.0032
Onchocerca volvulus 0.015 0.0574 0.2742
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0042 0.0037

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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