Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.1138 | 0.0906 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.5219 | 0.5094 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0255 | 0.0346 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.236 | 0.1897 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.1138 | 0.1701 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.1455 | 0.0937 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.1138 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1138 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2686 | 0.4014 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.2213 | 0.3307 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2941 | 0.4395 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.205 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.205 | 0.1842 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.7378 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.205 | 0.1842 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.205 | 0.2778 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.1138 | 0.0601 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.6692 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.1138 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2044 | 0.1835 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.5219 | 0.5094 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.237 | 0.3541 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.7263 | 0.7097 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.2213 | 0.2999 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.205 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.1138 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.2213 | 0.2009 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.1958 | 0.1747 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.2213 | 0.1741 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0.1138 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.2213 | 0.2999 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.2664 | 0.2472 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3921 | 0.5859 |
Brugia malayi | hypothetical protein | 0.0035 | 0.205 | 0.1568 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.5698 | 0.7722 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.205 | 0.5 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.1138 | 0.0906 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2044 | 0.1835 |
Echinococcus granulosus | peregrin | 0.0031 | 0.1455 | 0.1231 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.1455 | 0.1231 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.1138 | 0.1543 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.2664 | 0.2472 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.205 | 0.2778 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.1138 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.5286 | 0.7899 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.205 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.