Detailed information for compound 774452

Basic information

Technical information
  • TDR Targets ID: 774452
  • Name: 5-[(4-chloro-5-methyl-3-nitropyrazol-1-yl)met hyl]furan-2-carboxylic acid
  • MW: 285.641 | Formula: C10H8ClN3O5
  • H donors: 1 H acceptors: 5 LogP: 1.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1nn(c(c1Cl)C)Cc1ccc(o1)C(=O)O
  • InChi: 1S/C10H8ClN3O5/c1-5-8(11)9(14(17)18)12-13(5)4-6-2-3-7(19-6)10(15)16/h2-3H,4H2,1H3,(H,15,16)
  • InChiKey: SJJKQMUBDLEUNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-chloro-5-methyl-3-nitro-pyrazol-1-yl)methyl]furan-2-carboxylic acid
  • 5-[(4-chloro-5-methyl-3-nitro-1-pyrazolyl)methyl]-2-furancarboxylic acid
  • 5-[(4-chloro-5-methyl-3-nitro-pyrazol-1-yl)methyl]-2-furoic acid
  • Oprea1_243375
  • BAS 08302721
  • 5-(4-Chloro-5-methyl-3-nitro-pyrazol-1-ylmethyl)-furan-2-carboxylic acid
  • SBB009238

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.003 0.0729 0.0938
Trichomonas vaginalis heat shock protein, putative 0.0047 0.134 0.1526
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1 0.2358
Mycobacterium ulcerans heat shock protein 90 0.0044 0.1233 0.5881
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1911 0.2209
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.134 0.3538
Plasmodium vivax SET domain protein, putative 0.003 0.0729 0.1137
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0493 0.1394
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0606 0.0676
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.4102 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0715 0.086
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0715 0.2739
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Schistosoma mansoni chromobox protein 0.0071 0.2254 0.2236
Echinococcus multilocularis heat shock protein 90 0.0047 0.134 0.3231
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.1087 0.2659
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.134 0.3157
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0415 0.0522
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0729 0.0708
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.1414 0.1847
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0481 0.0738
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.1087 0.2659
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0715 0.137
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0481 0.0738
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.3203 0.7796
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1081 0.1226
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0063 0.1938 0.2543
Brugia malayi hypothetical protein 0.0037 0.0987 0.1281
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0715 0.137
Trichomonas vaginalis set domain proteins, putative 0.0241 0.8657 1
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0751 0.1173
Brugia malayi hypothetical protein 0.0067 0.2113 0.2775
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.137
Schistosoma mansoni lipoxygenase 0.012 0.4102 0.4089
Echinococcus granulosus transcription factor Dp 1 0.0039 0.1049 0.2516
Schistosoma mansoni endoplasmin 0.0047 0.134 0.1321
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1 0.1907
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.134 0.3538
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.2864 0.6966
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0022 0.00000011736
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0751 0.1173
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2254 0.2584
Schistosoma mansoni heat shock protein 0.0047 0.134 0.1321
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0715 0.1698
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2011 0.1994
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.1233 0.102
Brugia malayi Endoplasmin precursor 0.0047 0.134 0.175
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.3203 0.3188
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0715 0.2739
Loa Loa (eye worm) doublecortin family protein 0.002 0.0341 0.0423
Echinococcus granulosus voltage dependent calcium channel 0.0098 0.3266 0.795
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0493 0.1394
Toxoplasma gondii heat shock protein HSP90 0.0047 0.134 0.2121
Trypanosoma brucei polo-like protein kinase 0.0096 0.3203 1
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.1138 0.2734
Loa Loa (eye worm) hypothetical protein 0.0024 0.0493 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1081 0.1226
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.137
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0729 0.1732
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0751 0.1787
Schistosoma mansoni inositol monophosphatase 0.0038 0.1 0.098
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0715 0.086
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0481 0.1318
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0098 0.3266 0.3251
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.2845 0.4543
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0493 0.0046
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.2114 0.5998
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Brugia malayi glutathione reductase 0.0087 0.2845 0.3747
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0751 0.1787
Onchocerca volvulus 0.0085 0.277 0.3199
Loa Loa (eye worm) hypothetical protein 0.0024 0.0493 0.0626
Echinococcus multilocularis chromobox protein 1 0.0071 0.2254 0.5469
Plasmodium vivax heat shock protein, putative 0.0177 0.6236 1
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.277 0.6734
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.1414 0.224
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0481 0.0738
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0341 0.0512
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0729 0.1137
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0493 0.0017
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0715 0.1115
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0264 0.0389
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.086
Brugia malayi hypothetical protein 0.002 0.0341 0.0423
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.1087 0.2609
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0715 0.086
Leishmania major trypanothione reductase 0.0087 0.2845 0.8685
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0729 0.0708
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0098 0.3266 0.4305
Schistosoma mansoni lipoxygenase 0.0084 0.2743 0.2727
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Schistosoma mansoni rab6-interacting 0.002 0.0341 0.0319
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.1414 0.1395
Onchocerca volvulus 0.0024 0.0493 0.057
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.3203 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0198 0.7021 0.8912
Schistosoma mansoni loxhd1 0.002 0.0341 0.0319
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2011 0.264
Loa Loa (eye worm) hypothetical protein 0.0041 0.1138 0.1481
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1911 0.4629
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0493 0.1394
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.1 0.1132
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0493 0.1394
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0715 0.064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.1081 0.1249
Brugia malayi hypothetical protein 0.0037 0.0987 0.1281
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0341 0.078
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0715 0.1115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1911 1
Trichomonas vaginalis heat shock protein, putative 0.0044 0.1233 0.1402
Echinococcus granulosus expressed protein 0.0049 0.1414 0.3411
Echinococcus granulosus amyloid beta A4 protein 0.007 0.2216 0.5377
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0715 0.1698
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.0321
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.3203 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0715 0.086
Leishmania major heat shock protein, putative 0.0031 0.0751 0.0993
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.1 0.6906
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.1 0.1132
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0493 0.0626
Echinococcus granulosus heat shock protein 90 0.0047 0.134 0.3231
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.022 0.7851 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0852 0.0503
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1195 0.1358
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0493 0.1394
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1376 0.1568
Brugia malayi Inositol-1 0.0038 0.1 0.1298
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2011 0.264
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.2845 0.8758
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0729 0.1732
Schistosoma mansoni voltage-gated cation channel 0.0098 0.3266 0.3251
Loa Loa (eye worm) hypothetical protein 0.002 0.0341 0.0423
Onchocerca volvulus 0.0042 0.1165 0.1346
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.7556 1
Schistosoma mansoni amyloid beta A4 protein related 0.007 0.2216 0.2199
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.1 0.3074
Toxoplasma gondii Hsp90 domain-containing protein 0.0177 0.6236 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0098 0.3266 0.795
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.1087 0.1494
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Brugia malayi Heterochromatin protein 1 0.0071 0.2254 0.2962
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0341 0.078
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0715 0.3114
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0715 0.086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.137
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.1 0.1132
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0493 0.0626
Onchocerca volvulus 0.0031 0.0758 0.0876
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.3203 0.37
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0715 0.3114
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0341 0.078
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.1 0.4469
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0715 0.0694
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.0321
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.3203 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0263 0.032
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.2114 0.6575
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0729 0.0708
Plasmodium falciparum glutathione reductase 0.0087 0.2845 0.4543
Echinococcus multilocularis heat shock protein 90 0.004 0.1087 0.2609
Echinococcus granulosus Chromobox protein 3 0.0012 0.0022 0.00000011736
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.086
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Loa Loa (eye worm) hypothetical protein 0.0085 0.277 0.3647
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0493 0.1482
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.134 0.3538
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0098 0.3266 0.3251
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.277 0.3647
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0493 0.1394
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0098 0.3266 0.795
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.277 0.6734
Brugia malayi hypothetical protein 0.002 0.0341 0.0423
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0715 0.0802
Brugia malayi Pre-SET motif family protein 0.0212 0.7556 1
Plasmodium vivax endoplasmin, putative 0.0047 0.134 0.2121
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Mycobacterium tuberculosis Probable dehydrogenase 0.0198 0.7021 0.8912
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0481 0.1318
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0356 0.0818
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2011 0.264
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0859 0.0969
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Treponema pallidum NADH oxidase 0.003 0.0715 0.3114
Brugia malayi Hsp90 protein 0.0031 0.0751 0.0968
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0041 0.1147 0.2756
Onchocerca volvulus 0.0012 0.0022 0.0026
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0852 0.082
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.2114 0.6221
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0715 0.092
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.134 0.3538
Loa Loa (eye worm) hypothetical protein 0.0067 0.2113 0.2775
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.0321
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.2864 0.6966
Loa Loa (eye worm) hypothetical protein 0.0024 0.0493 0.0626
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0493 0.1482
Schistosoma mansoni hypothetical protein 0.0041 0.1138 0.1118
Schistosoma mansoni kinase 0.0049 0.1424 0.1405
Echinococcus multilocularis amyloid beta A4 protein 0.007 0.2216 0.5377
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0715 0.2739
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.2845 0.3747
Schistosoma mansoni chromobox protein 0.0071 0.2254 0.2236
Loa Loa (eye worm) hypothetical protein 0.0031 0.0758 0.0977
Echinococcus multilocularis voltage dependent calcium channel 0.0098 0.3266 0.795
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0715 1
Plasmodium falciparum thioredoxin reductase 0.0087 0.2845 0.4543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0493 0.035
Brugia malayi TAR-binding protein 0.0064 0.2011 0.264
Mycobacterium ulcerans hypothetical protein 0.0024 0.0493 0.1394
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0751 0.0993
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0198 0.7021 0.8912
Mycobacterium tuberculosis Probable reductase 0.0198 0.7021 0.8912
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.0321
Echinococcus multilocularis chromobox protein 1 0.0071 0.2254 0.5469
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0481 0.0333
Plasmodium vivax glutathione reductase, putative 0.0087 0.2845 0.4543
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0059 0.1824 0.5217
Schistosoma mansoni hypothetical protein 0.002 0.0341 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1911 0.1893
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.2114 0.5126
Trichomonas vaginalis heat shock protein, putative 0.0044 0.1233 0.1402
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1911 0.3039
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.022 0.7851 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.2114 0.6221
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Echinococcus granulosus RUN 0.002 0.0341 0.078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.1165 0.1146
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1376 0.1568
Brugia malayi chromobox protein homolog 3 0.004 0.1081 0.1406
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.1414 0.224
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.1195 0.138
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.2114 0.2776
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0493 0.0626
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2011 0.1994
Loa Loa (eye worm) X11 protein 0.007 0.2216 0.2912
Onchocerca volvulus 0.0241 0.8657 1
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0098 0.3266 0.795
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0751 0.0968
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.1233 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0198 0.7021 0.8912
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0493 0.1482
Loa Loa (eye worm) hypothetical protein 0.0098 0.3266 0.4305
Brugia malayi Doublecortin family protein 0.002 0.0341 0.0423
Schistosoma mansoni heat shock protein 0.0047 0.134 0.1321
Echinococcus granulosus endoplasmin 0.0044 0.1233 0.2966
Treponema pallidum heat shock protein 90 0.0044 0.1233 1
Echinococcus multilocularis sodium channel protein 0.0041 0.1147 0.2756
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0415 0.0522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.137
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0198 0.7021 0.8912
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.1138 0.1795
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.1 0.2397
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.1138 0.1481
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0356 0.0537
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.134 0.3157
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1195 0.1358
Trypanosoma brucei trypanothione reductase 0.0087 0.2845 0.8685
Plasmodium falciparum heat shock protein 90, putative 0.0177 0.6236 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0493 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2011 0.1994
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.134 0.4144
Brugia malayi heat shock protein 90 0.0047 0.134 0.175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1911 0.5253
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2011 0.1994
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.0321
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0481 0.4813
Echinococcus granulosus tar DNA binding protein 0.0064 0.2011 0.4876
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.134 0.2513
Toxoplasma gondii thioredoxin reductase 0.0087 0.2845 0.4543
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.137
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0729 0.1732
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0341 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0644 0.0721
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0341 0.078
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.1049 0.2516
Schistosoma mansoni polycystin 1-related 0.002 0.0341 0.0319
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.2114 0.5998
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0264 0.0049
Echinococcus multilocularis voltage dependent calcium channel 0.0098 0.3266 0.795
Onchocerca volvulus 0.002 0.0341 0.0393
Loa Loa (eye worm) hypothetical protein 0.003 0.0729 0.0938
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.1233 0.2761
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1 0.2358
Echinococcus multilocularis heat shock protein 0.0047 0.134 0.3231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0715 0.137
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0751 0.2292
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0493 0.0017
Loa Loa (eye worm) inositol-1 0.0038 0.1 0.1298
Loa Loa (eye worm) hypothetical protein 0.002 0.0341 0.0423
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0715 0.1115
Loa Loa (eye worm) hypothetical protein 0.004 0.1081 0.1406
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0687 0.1629
Echinococcus granulosus chromobox protein 1 0.0071 0.2254 0.5469
Plasmodium falciparum glutathione reductase 0.003 0.0715 0.1115
Trichomonas vaginalis heat shock protein, putative 0.004 0.1087 0.1233
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Schistosoma mansoni heat shock protein 0.0031 0.0751 0.0731
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.022 0.7851 1
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Brugia malayi RNA binding protein 0.0064 0.2011 0.264
Echinococcus multilocularis endoplasmin 0.0044 0.1233 0.2966
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Plasmodium vivax heat shock protein 86, putative 0.0047 0.134 0.2121
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.1 0.2397
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.2114 0.5126
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.1138 0.1795
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.1138 0.1481
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2011 0.1994
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.1414 0.224
Echinococcus multilocularis RUN 0.002 0.0341 0.078
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2011 0.4876
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0644 0.0721
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2254 0.2584
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.1138 0.1795
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0493 0.035
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0356 0.0443
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.1138 0.1481
Loa Loa (eye worm) calcium channel 0.0098 0.3266 0.4305
Schistosoma mansoni inositol monophosphatase 0.0038 0.1 0.098
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.1 0.1574
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0098 0.3266 0.795
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1911 1
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.134 0.2121
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.2845 0.3434
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3203 0.3684
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0059 0.1824 0.4935
Giardia lamblia Kinase, PLK 0.0096 0.3203 1
Toxoplasma gondii hypothetical protein 0.0018 0.0263 0.0388
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.134 0.3538
Loa Loa (eye worm) RNA binding protein 0.0064 0.2011 0.264
Plasmodium falciparum endoplasmin, putative 0.0034 0.0859 0.1347
Entamoeba histolytica hypothetical protein 0.0024 0.0481 0.1442
Loa Loa (eye worm) endoplasmin 0.0047 0.134 0.175
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.134 0.4144
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.4102 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.2114 0.2776
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.1414 0.1847
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.2254 0.2962
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.3203 0.4222
Loa Loa (eye worm) hypothetical protein 0.002 0.0356 0.0443
Brugia malayi Thioredoxin reductase 0.0087 0.2845 0.3747
Trypanosoma brucei heat shock protein, putative 0.0047 0.134 0.3157
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0751 0.1495
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.1233 0.1319
Echinococcus multilocularis expressed protein 0.0049 0.1414 0.3411
Schistosoma mansoni endoplasmin 0.0047 0.134 0.1321
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0198 0.7021 0.8874
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0098 0.3266 0.795
Loa Loa (eye worm) hypothetical protein 0.0018 0.0263 0.032
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0606 0.0939
Loa Loa (eye worm) heat shock protein 90 0.0047 0.134 0.175
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0493 0.0046
Loa Loa (eye worm) glutathione reductase 0.0087 0.2845 0.3747
Plasmodium falciparum thioredoxin reductase 0.003 0.0715 0.1115
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0098 0.3266 0.795
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0715 0.0802
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0341 0.078
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1911 0.1893
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0715 0.1115
Mycobacterium tuberculosis Probable oxidoreductase 0.022 0.7851 1
Schistosoma mansoni rab6-interacting 0.002 0.0341 0.0319
Echinococcus granulosus heat shock protein 0.0047 0.134 0.3231
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.277 0.2754
Leishmania major heat shock protein 83-1 0.0047 0.134 0.3157
Plasmodium falciparum heat shock protein 90 0.0047 0.134 0.2121
Echinococcus granulosus heat shock protein 90 0.004 0.1087 0.2609
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.134 0.3157
Onchocerca volvulus 0.0012 0.0022 0.0026
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0859 0.0969
Brugia malayi SET domain containing protein 0.0013 0.0064 0.0056
Onchocerca volvulus 0.002 0.0341 0.0393
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0481 0.0738
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.1 0.1907
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0751 0.0868
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0341 0.0512
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0715 0.1115
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0715 0.1115
Giardia lamblia Grp94/Hsp90 0.0044 0.1233 0.208
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.1414 0.224
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0264 0.0389
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0493 0.1394
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0098 0.3266 0.795
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0715 0.137
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.3203 0.4222
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.3203 0.7796
Echinococcus granulosus chromobox protein 1 0.0071 0.2254 0.5469
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.3203 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1911 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0715 0.086
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.2114 0.2096
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1911 0.4629

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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