Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0072 | 0.065 | 0.0644 | |
Echinococcus granulosus | acetylcholinesterase | 0.0201 | 0.2879 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0007 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0201 | 0.2879 | 1 |
Plasmodium vivax | cytochrome c, putative | 0.01 | 0.1131 | 0.4893 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0201 | 0.2879 | 0.5368 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0034 | 0.0007 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0168 | 0.2312 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0201 | 0.2879 | 0.4044 |
Echinococcus granulosus | acetylcholinesterase | 0.0201 | 0.2879 | 1 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0346 | 0.5358 | 0.7533 |
Loa Loa (eye worm) | STAT protein | 0.0346 | 0.5358 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0168 | 0.2312 | 1 |
Echinococcus granulosus | cytochrome c | 0.01 | 0.1131 | 0.3914 |
Echinococcus multilocularis | cytochrome c | 0.01 | 0.1131 | 0.3914 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0201 | 0.2879 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0201 | 0.2879 | 0.4044 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0072 | 0.065 | 0.1203 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2879 | 0.5368 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0007 | 0.5 |
Toxoplasma gondii | cytochrome c, putative | 0.01 | 0.1131 | 0.4893 |
Schistosoma mansoni | cytochrome c | 0.01 | 0.1131 | 0.3914 |
Giardia lamblia | Telomerase catalytic subunit | 0.0168 | 0.2312 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0168 | 0.2312 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0034 | 0.0007 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0168 | 0.2312 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0168 | 0.2312 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0201 | 0.2879 | 1 |
Brugia malayi | Cytochrome c type-1 | 0.01 | 0.1131 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2879 | 0.5368 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0168 | 0.2312 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0168 | 0.2312 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.01 | 0.1131 | 0.5 |
Mycobacterium leprae | Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0201 | 0.2879 | 0.5368 |
Brugia malayi | Telomerase reverse transcriptase | 0.0448 | 0.7111 | 1 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0072 | 0.065 | 0.0906 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.065 | 0.2241 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0201 | 0.2879 | 1 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.01 | 0.1131 | 0.2101 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0034 | 0.0007 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0034 | 0.0007 | 0.5 |
Plasmodium falciparum | cytochrome c, putative | 0.01 | 0.1131 | 0.4893 |
Echinococcus multilocularis | acetylcholinesterase | 0.0201 | 0.2879 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Compound was evaluated for analgesic activity using mouse hot-plate test, at the dose 20 mg/kg; Inactive | ChEMBL. | 3746823 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.