Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.045 | 1 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.045 | 1 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.045 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.045 | 1 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.045 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0338 | 0.4102 | 0.4102 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.045 | 1 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.045 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.045 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0351 | 0.4801 | 0.4801 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.045 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.