TDR Targets

Basic information

Technical information

TDR Targets ID: 775132
Name: 4-methoxy-N-(8-methyl-6,7,8,9-tetrahydrodiben zofuran-2-yl)benzenesulfonamide
MW: 371.45 | Formula: C20H21NO4S
H donors: 1 H acceptors: 2 LogP: 4.3 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)Nc1ccc2c(c1)c1CC(C)CCc1o2
InChi: 1S/C20H21NO4S/c1-13-3-9-19-17(11-13)18-12-14(4-10-20(18)25-19)21-26(22,23)16-7-5-15(24-2)6-8-16/h4-8,10,12-13,21H,3,9,11H2,1-2H3
InChiKey: NYBDTHIQZSLAIF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

AP-906/41639369
EU-0048449

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0096	0.3475	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.3301	0.9845
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0944	0.2717
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.3352	0.4728
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0563	0.1516
Giardia lamblia	Rrm3p helicase	0.0096	0.3475	1
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2941	0.8882
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2941	0.8745
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0413	0.1188
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.0224
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0413	0.1033
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1634	0.225
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.3301	0.4655
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.2382	0.3329
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0413	0.1049
Echinococcus granulosus	chromobox protein 1	0.0068	0.2076	0.2888
Onchocerca volvulus	Peroxidasin homolog	0.0085	0.2941	0.8882
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.3301	0.9432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0413	0.1049
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.3301	0.4655
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2941	0.8745
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2941	0.8882
Giardia lamblia	Kinase, PLK	0.0092	0.3301	0.9488
Echinococcus granulosus	geminin	0.0165	0.7007	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Onchocerca volvulus		0.0035	0.0413	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Echinococcus multilocularis	chromobox protein 1	0.0068	0.2076	0.2888
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.1608	0.4754
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0413	0.1049
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0096	0.3475	0.4906
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2941	0.8882
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0944	0.2717
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0563	0.1516
Brugia malayi	beta-lactamase family protein	0.0035	0.0413	0.1033
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0096	0.3475	1
Onchocerca volvulus	Peroxidase homolog	0.0085	0.2941	0.8882
Brugia malayi	jmjC domain containing protein	0.0034	0.0377	0.0925
Schistosoma mansoni	chromobox protein	0.0068	0.2076	0.2888
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0413	0.1188
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.071	0.197
Schistosoma mansoni	hypothetical protein	0.0165	0.7007	1
Onchocerca volvulus		0.0085	0.2941	0.8882
Schistosoma mansoni	hypothetical protein	0.0165	0.7007	1
Entamoeba histolytica	hypothetical protein, conserved	0.0096	0.3475	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0413	0.0488
Onchocerca volvulus	Dual oxidase homolog	0.0085	0.2941	0.8882
Trypanosoma brucei	polo-like protein kinase	0.0092	0.3301	0.9432
Echinococcus granulosus	peroxidasin	0.0085	0.2941	0.4135
Schistosoma mansoni	peroxidasin	0.0085	0.2941	0.4135
Schistosoma mansoni	chromobox protein	0.0068	0.2076	0.2888
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1634	0.225
Echinococcus multilocularis	geminin	0.0165	0.7007	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0085	0.2941	0.8882
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1103	0.3189
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0377	0.0437
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0638	0.0814
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0377	0.0437
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0377	0.0939
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0413	0.1188
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0096	0.3475	1
Onchocerca volvulus		0.0085	0.2941	0.8882
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0096	0.3475	1
Brugia malayi	Peroxidasin	0.0085	0.2941	0.8745
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Brugia malayi	Heterochromatin protein 1	0.0068	0.2076	0.6108
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.3301	0.9432
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1634	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Brugia malayi	chromobox protein homolog 3	0.0038	0.0563	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0413	0.1049
Loa Loa (eye worm)	blistered cuticle protein 3	0.0085	0.2941	0.8882
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0413	0.1049
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1634	0.3988
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1634	0.225
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2941	0.8745
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.2076	0.5975
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0413	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0413	0.1049
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1634	0.225
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0563	0.1621
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0096	0.3475	1
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0413	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1634	1
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.071	0.2043
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0638	0.0814
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0377	0.0437
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0096	0.3475	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.2076	0.6204
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.071	0.2043
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1634	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1634	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.3301	0.4655
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.2076	0.5975
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0413	0.1188
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0413	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1634	0.1274
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.3301	0.9432
Schistosoma mansoni	peroxidasin	0.0085	0.2941	0.4135
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0413	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.3352	0.4728
Brugia malayi	beta-lactamase	0.0035	0.0413	0.1033
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0413	0.0488
Brugia malayi	hypothetical protein	0.0085	0.2941	0.8745
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0096	0.3475	0.4906
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Echinococcus multilocularis	peroxidasin	0.0085	0.2941	0.4135
Trichomonas vaginalis	esterase, putative	0.0035	0.0413	0.1188
Onchocerca volvulus		0.0035	0.0413	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.3301	1
Echinococcus multilocularis	chromobox protein 1	0.0068	0.2076	0.2888
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Onchocerca volvulus		0.003	0.0147	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0563	0.1621
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2941	0.8745
Onchocerca volvulus	Peroxidase homolog	0.0085	0.2941	0.8882
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0096	0.3475	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0413	0.5
Onchocerca volvulus		0.0085	0.2941	0.8882
Onchocerca volvulus		0.0035	0.0413	0.1049
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.3301	0.9499
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2941	0.8745
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.3301	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0377	0.0437
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0096	0.3475	1
Onchocerca volvulus	Peroxidasin homolog	0.0085	0.2941	0.8882
Toxoplasma gondii	ABC1 family protein	0.0035	0.0413	0.217
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.3475	1
Schistosoma mansoni	kinase	0.0047	0.1006	0.1344
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Echinococcus granulosus	chromobox protein 1	0.0068	0.2076	0.2888
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0413	0.1049
Schistosoma mansoni	hypothetical protein	0.0096	0.3475	0.4906
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Brugia malayi	Blistered cuticle protein 3	0.0085	0.2941	0.8745
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2941	0.8882
Brugia malayi	jmjC domain containing protein	0.0093	0.3352	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0413	0.0488
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2941	0.8882
Brugia malayi	beta-lactamase family protein	0.0035	0.0413	0.1033
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0074	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0413	0.1188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 775132