Detailed information for compound 775404

Basic information

Technical information
  • TDR Targets ID: 775404
  • Name: ethyl 5-[(4-chloro-3-methylphenyl)sulfonylami no]-2-methylbenzo[g][1]benzoxole-3-carboxylat e
  • MW: 457.927 | Formula: C23H20ClNO5S
  • H donors: 1 H acceptors: 3 LogP: 5.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(C)oc2c1cc(NS(=O)(=O)c1ccc(c(c1)C)Cl)c1c2cccc1
  • InChi: 1S/C23H20ClNO5S/c1-4-29-23(26)21-14(3)30-22-17-8-6-5-7-16(17)20(12-18(21)22)25-31(27,28)15-9-10-19(24)13(2)11-15/h5-12,25H,4H2,1-3H3
  • InChiKey: IZGCRYRTLMHMMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 5-[(4-chloro-3-methyl-phenyl)sulfonylamino]-2-methyl-benzo[g]benzofuran-3-carboxylate
  • 5-[(4-chloro-3-methylphenyl)sulfonylamino]-2-methyl-3-benzo[g]benzofurancarboxylic acid ethyl ester
  • 5-[(4-chloro-3-methyl-phenyl)sulfonylamino]-2-methyl-benzo[g]benzofuran-3-carboxylic acid ethyl ester
  • ethyl 5-[(4-chloro-3-methyl-phenyl)sulfonylamino]-2-methyl-benzo[g][1]benzoxole-3-carboxylate
  • EU-0015038

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0154 0.034 0.1415
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0026 0.0053
Entamoeba histolytica hypothetical protein, conserved 0.2018 0.4863 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.034 0.1467
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0002 0.0009
Onchocerca volvulus 0.0154 0.034 0.3078
Loa Loa (eye worm) hypothetical protein 0.0154 0.034 0.1467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0042 0.0181
Schistosoma mansoni alpha glucosidase 0.0037 0.0056 0.0112
Onchocerca volvulus 0.0016 0.0006 0.0056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.012
Onchocerca volvulus 0.0154 0.034 0.3078
Brugia malayi ecdysteroid receptor 0.0031 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0154 0.034 0.1467
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0026 0.0053
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0372 0.037
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0042 0.0082
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0026 0.0053
Onchocerca volvulus 0.0016 0.0006 0.0056
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.012
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0007 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0046 0.1184
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0019 0.0378
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0061 0.0125
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0042 0.0082
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0058 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0427 0.0875
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0724 0.3125
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0042 0.0379
Trypanosoma brucei hypothetical protein, conserved 0.0154 0.034 0.0699
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.003
Trichomonas vaginalis ran, putative 0.0022 0.0019 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0138
Loa Loa (eye worm) fibroinase 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0154 0.034 0.1467
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0006 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0046 0.0044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0061 0.0125
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0085 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0042 0.0181
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0058 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0015 0.2314
Schistosoma mansoni hypothetical protein 0.0312 0.0724 0.1485
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0447 0.0915
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0042 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0427 0.0875
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.0447 0.1929
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0343 0.148
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0042 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Entamoeba histolytica hypothetical protein 0.0071 0.014 0.0287
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0007 0.001
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0046 0.0197
Loa Loa (eye worm) hypothetical protein 0.0049 0.0086 0.037
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0013
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0011 0.1172
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0026 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.034 0.0699
Leishmania major DNA polymerase eta, putative 0.0037 0.0056 0.0115
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0056 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0042 0.0181
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.0966 0.417
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0019 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.011 0.0222
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0061 0.0059
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0042 0.0082
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0372 0.1604
Plasmodium vivax SET domain protein, putative 0.0059 0.011 0.3109
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Echinococcus multilocularis tar DNA binding protein 0.0198 0.0447 0.0445
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0002 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0117 0.0242
Echinococcus multilocularis GPCR, family 2 0.0049 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0026 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0042 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0469 0.1104 0.2271
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0042 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0013
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0032 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0224 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0106 0.0224 0.0966
Echinococcus multilocularis smad 0.0017 0.0007 0.0005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0983 0.2352 1
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.003
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.2018 0.4863 0.4862
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0049 0.0731
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0037 0.0939
Onchocerca volvulus 0.0016 0.0006 0.0056
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0046 0.0094
Entamoeba histolytica hypothetical protein 0.0071 0.014 0.0287
Loa Loa (eye worm) beta-lactamase 0.0154 0.034 0.1467
Brugia malayi tailless protein 0.0015 0.0002 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0086 0.037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.011 0.0108
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0006 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0032 0.0066
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0002 0.0009
Mycobacterium leprae Probable lipase LipE 0.0154 0.034 1
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.034 0.0699
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0026 0.0455
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0121 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.034 0.0699
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0015 0.0031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.034 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Loa Loa (eye worm) DR-78 0.0015 0.0002 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0086 0.0084
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0046 0.0197
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0061 0.0223
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0032 0.6513
Brugia malayi hypothetical protein 0.0969 0.2317 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0006 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.014 0.0138
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0061 0.0125
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.319
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0042 0.004
Schistosoma mansoni ran 0.0022 0.0019 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0031 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0042 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0042 0.0181
Onchocerca volvulus 0.0154 0.034 0.3078
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0026 0.0455
Mycobacterium tuberculosis Probable lipase LipE 0.0154 0.034 0.1415
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0026 0.0053
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0046 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0447 0.0915
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0071 0.014 0.0283
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0343 0.148
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0006 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0032 0.0771
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Echinococcus granulosus cathepsin l1 0.0016 0.0006 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0037 0.0077
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0042 0.0082
Leishmania major cathepsin L-like protease 0.0062 0.0117 0.0242
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0026 0.0455
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0015 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0121 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Entamoeba histolytica DNA repair and recombination protein, putative 0.2018 0.4863 1
Leishmania major hypothetical protein, conserved 0.0154 0.034 0.0699
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0061 0.0262
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0193 0.0435 0.3936
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0042 0.004
Giardia lamblia Rrm3p helicase 0.2018 0.4863 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Brugia malayi hypothetical protein 0.0017 0.0009 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0056 0.0116
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0056 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0047
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0056 0.1494
Echinococcus granulosus tar DNA binding protein 0.0198 0.0447 0.0915
Mycobacterium ulcerans lipase LipD 0.0154 0.034 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.011 0.0222
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0121 0.0522
Entamoeba histolytica cysteine protease, putative 0.0016 0.0006 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0042 0.0181
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0061 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0056 0.0116
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.2018 0.4863 1
Echinococcus granulosus GPCR family 2 0.0049 0.0086 0.0172
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Schistosoma mansoni hypothetical protein 0.0106 0.0224 0.0456
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0154 0.034 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0032 0.0771
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0026 0.0111
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0042 0.0082
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0447 0.0915
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0058 0.1564
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0046 0.0044
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.034 0.0699
Loa Loa (eye worm) hypothetical protein 0.0155 0.0343 0.148
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0154 0.034 0.1467
Trypanosoma brucei unspecified product 0.0027 0.0031 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Entamoeba histolytica Ran family GTPase 0.0022 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0154 0.034 0.1467
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0031 0.0065
Toxoplasma gondii exonuclease III APE 0.002 0.0015 0.0274
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Loa Loa (eye worm) cysteine protease 0.0016 0.0006 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0024 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0427 0.0425
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0061 0.0125
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0024 0.0049
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0172
Echinococcus granulosus survival motor neuron protein 1 0.0969 0.2317 0.4762
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0372 0.1604
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0046 0.0159
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.0071 0.014 0.0287
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0198 0.0446 0.1925
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0026 0.0111
Loa Loa (eye worm) ctsf protein 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0042 0.0181
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0006 0.0013
Schistosoma mansoni ran 0.0022 0.0019 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0447 0.0915
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0056 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0056 0.0116
Schistosoma mansoni smad 0.0017 0.0007 0.001
Leishmania major cathepsin L-like protease 0.0062 0.0117 0.0242
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0056 0.0115
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0056 0.0116
Entamoeba histolytica hypothetical protein 0.0071 0.014 0.0287
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0154 0.034 0.1467
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0015 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0032 0.0066
Brugia malayi hypothetical protein 0.0071 0.014 0.0603
Leishmania major GTP-binding protein, putative 0.0022 0.0019 0.0039
Schistosoma mansoni DNA polymerase eta 0.0064 0.0121 0.0245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0047
Loa Loa (eye worm) DEAH box polypeptide 35 0.0038 0.0058 0.0252
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0252
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0042 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.034 0.0699
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0046 0.009
Brugia malayi nuclear receptor RXR 0.0015 0.0002 0.0009
Trypanosoma brucei glucosidase, putative 0.0037 0.0056 0.0116
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0111
Schistosoma mansoni alpha-glucosidase 0.0144 0.0315 0.0644
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.014 0.0283
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0046 0.1184
Brugia malayi hypothetical protein 0.0015 0.0002 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0042 0.0181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0042 0.0082
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0002 0.0019
Brugia malayi hypothetical protein 0.0016 0.0006 0.0027
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.003
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0049 0.0172
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0056 0.0116
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0061 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0026 0.0111
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.011 0.0222
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0061 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0154 0.034 0.1415
Trichomonas vaginalis esterase, putative 0.0154 0.034 0.0699
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.034 0.0699
Onchocerca volvulus 0.0097 0.0201 0.1818
Echinococcus multilocularis beta LACTamase domain containing family member 0.0154 0.034 0.0338
Onchocerca volvulus 0.0024 0.0026 0.0233
Mycobacterium tuberculosis Conserved protein 0.0154 0.034 0.1415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0042 0.0082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0042 0.0082
Leishmania major hypothetical protein, conserved 0.0027 0.0032 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Brugia malayi conserved hypotetical protein 0.0015 0.0002 0.0009
Brugia malayi Pre-SET motif family protein 0.0059 0.011 0.0474
Brugia malayi isocitrate dehydrogenase 0.0033 0.0046 0.0197
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0006 0.0056
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0042 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Mycobacterium ulcerans esterase/lipase LipP 0.0154 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0086 0.037
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0002 0.0009
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.2018 0.4863 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0088 0.0181 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0026 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Onchocerca volvulus 0.0031 0.0042 0.0379
Brugia malayi nuclear receptor RXR 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Leishmania major DNA polymerase eta, putative 0.0064 0.0121 0.0249
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.0081
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.2018 0.4863 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.0116
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0019 0.0034
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.5
Schistosoma mansoni coup transcription factor 0.0031 0.0042 0.0082
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0042 0.0082
Brugia malayi Smad1 0.0017 0.0007 0.003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0015 0.0137
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0031
Schistosoma mansoni hypothetical protein 0.0198 0.0446 0.0913
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0015 0.0013
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.2018 0.4863 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.001
Leishmania major cathepsin L-like protease 0.0062 0.0117 0.0242
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.0559 0.2411
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0042 0.004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0002 0.0009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0046 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Schistosoma mansoni hypothetical protein 0.0519 0.1225 0.2516
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0009
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.2018 0.4863 1
Brugia malayi beta-lactamase 0.0154 0.034 0.1467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0042 0.0181
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0042 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0427 0.0875
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0042 0.0181
Brugia malayi N-terminal motif family protein 0.0193 0.0435 0.1876
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0007 0.0005
Onchocerca volvulus 0.0469 0.1104 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0056 0.0116
Onchocerca volvulus 0.0016 0.0006 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.034 0.0699
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.2018 0.4863 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0154 0.034 0.0695
Schistosoma mansoni Smad4 0.0017 0.0007 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.011 0.0222
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Echinococcus multilocularis geminin 0.0519 0.1225 0.1224
Brugia malayi hypothetical protein 0.0027 0.0032 0.0138
Onchocerca volvulus 0.0015 0.0002 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0061 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.007 0.0304
Plasmodium vivax hypothetical protein, conserved 0.0154 0.034 1
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0061 0.0262
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0056 0.0054
Brugia malayi Cytochrome P450 family protein 0.0043 0.007 0.0304
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0019 0.0378
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0002 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.4863 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0037 0.0077
Brugia malayi beta-lactamase family protein 0.0154 0.034 0.1467
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0007 0.001
Plasmodium falciparum importin beta, putative 0.0029 0.0037 0.793
Brugia malayi Probable ATP-dependent helicase DHX35 0.0038 0.0058 0.0252
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Schistosoma mansoni survival motor neuron protein 0.0198 0.0446 0.0913
Echinococcus granulosus snurportin 1 0.0312 0.0724 0.1485
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0047
Onchocerca volvulus 0.0016 0.0006 0.0056
Brugia malayi ecdysone receptor 0.0015 0.0002 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0042 0.0082
Echinococcus multilocularis Smad4 0.0017 0.0007 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0042 0.0181
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0104 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0427 0.0875
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0007 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0042 0.0181
Schistosoma mansoni importin beta-1 0.0029 0.0037 0.0073
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0058 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0154 0.034 0.1415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0046 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Echinococcus granulosus Smad4 0.0017 0.0007 0.001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0372 0.037
Loa Loa (eye worm) TAR-binding protein 0.0198 0.0447 0.1929
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Brugia malayi hypothetical protein 0.0015 0.0002 0.0009
Trypanosoma brucei unspecified product 0.0027 0.0031 0.0065
Onchocerca volvulus 0.0059 0.011 0.0995
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0056 0.0116
Schistosoma mansoni hypothetical protein 0.0519 0.1225 0.2516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Mycobacterium ulcerans hypothetical protein 0.0154 0.034 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0427 0.1845
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.2018 0.4863 1
Mycobacterium tuberculosis Probable hydrolase 0.0154 0.034 0.1415
Echinococcus granulosus importin subunit beta 1 0.0029 0.0037 0.0073
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0061 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0042 0.0181
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0006 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.2018 0.4863 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.034 0.1467
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0002 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0015 0.0031
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0046 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0047
Mycobacterium tuberculosis Probable esterase LipL 0.0154 0.034 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0042 0.0181
Loa Loa (eye worm) Smad1 0.0017 0.0007 0.003
Mycobacterium tuberculosis Probable lipase LipD 0.0154 0.034 0.1415
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0042 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.0116
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0058 0.012
Echinococcus multilocularis dna polymerase eta 0.0064 0.0121 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0042 0.0181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0427 0.1845
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0061 0.0121
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0061 0.1516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0026 0.0074
Loa Loa (eye worm) hypothetical protein 0.0969 0.2317 1
Trypanosoma brucei unspecified product 0.0039 0.0061 0.0125
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.003
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0027
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.001
Echinococcus granulosus geminin 0.0519 0.1225 0.2516
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0343 0.148
Echinococcus multilocularis snurportin 1 0.0312 0.0724 0.0722
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0042 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0056 0.0116
Onchocerca volvulus 0.0198 0.0446 0.4038
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0019 0.0017
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0172
Giardia lamblia DINP protein human, muc B family 0.0039 0.0061 0.0094
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0105 0.0211
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0007 0.003
Mycobacterium ulcerans beta-lactamase 0.0154 0.034 1
Brugia malayi steroid hormone receptor 0.0031 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0059 0.011 0.0474
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0172
Brugia malayi nuclear hormone receptor 0.0015 0.0002 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0015 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0024 0.0049
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0372 0.076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0042 0.0181
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Onchocerca volvulus 0.0016 0.0006 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0056 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0042 0.004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0042 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0042 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0006 0.0013
Brugia malayi RNA binding protein 0.0198 0.0447 0.1929
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0046 0.0044
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0015 0.5
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0042 0.0082
Echinococcus granulosus dna polymerase kappa 0.0039 0.0061 0.0121
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.011 0.0108
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0015 0.0066
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0011 0.0139
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0056 0.0243
Mycobacterium leprae conserved hypothetical protein 0.0154 0.034 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Brugia malayi hypothetical protein 0.0016 0.0006 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.014 0.0283
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0042 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0042 0.0082
Brugia malayi Inositol-1 0.0038 0.0058 0.0252
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0046 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Echinococcus granulosus smad 0.0017 0.0007 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Brugia malayi nuclear receptor NHR-88 0.0015 0.0002 0.0009
Onchocerca volvulus 0.0015 0.0002 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0086 0.0172
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0031
Entamoeba histolytica hypothetical protein 0.0024 0.0024 0.0049
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0056 0.0243
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0111
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0015 0.0027
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.2018 0.4863 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0042 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0117 0.0242
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0046 0.1184
Leishmania major importin beta-1 subunit, putative 0.0024 0.0024 0.0049
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0061 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.0447 0.1929
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0026 0.0455
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0015 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0056 0.1506
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0058 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0026 0.0455
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0117 0.0242
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0037 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0427 0.0425
Plasmodium vivax importin-beta 2, putative 0.0029 0.0037 0.0939
Mycobacterium tuberculosis Conserved protein 0.0154 0.034 0.1415
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0181
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0088 0.0181 0.0372
Schistosoma mansoni alpha-glucosidase 0.0144 0.0315 0.0644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0042 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Brugia malayi Pre-SET motif family protein 0.0412 0.0966 0.417
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0046 0.0094
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0042 0.0082
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0117 0.0242
Loa Loa (eye worm) hypothetical protein 0.0088 0.0181 0.078
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0042 0.0181
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.011 0.3109
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0006 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0042 0.0181
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0061 0.1516
Brugia malayi beta-lactamase family protein 0.0154 0.034 0.1467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0086 0.037
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0116
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0026 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.011 0.0222
Loa Loa (eye worm) hypothetical protein 0.0064 0.0121 0.0522
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0042 0.0379
Brugia malayi Importin beta-1 subunit 0.0029 0.0037 0.0162
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0004
Brugia malayi nuclear receptor NHR-67 0.0015 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0049 0.0086 0.0172
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0162
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0061 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0086 0.0172
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0002 0.0009
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0024 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0019 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.034 0.0695
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0086 0.0084
Leishmania major DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0019 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0198 0.0447 0.0915
Onchocerca volvulus 0.0016 0.0006 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0427 0.0875
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0061 0.0125
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.0559 0.2411
Toxoplasma gondii ABC1 family protein 0.0154 0.034 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0117 0.0242
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0042 0.0082
Brugia malayi TAR-binding protein 0.0198 0.0447 0.1929
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0032 0.6513
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.0193 0.0435 0.1876
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0006 0.0009
Brugia malayi RNA, U transporter 1 0.0083 0.0168 0.0727
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0056 0.0116
Brugia malayi MH2 domain containing protein 0.0244 0.0559 0.2411
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0058 0.1445
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0042 0.0379
Echinococcus multilocularis survival motor neuron protein 1 0.0969 0.2317 0.2315
Brugia malayi nuclear hormone receptor 0.0031 0.0042 0.0181
Loa Loa (eye worm) inositol-1 0.0038 0.0058 0.0252
Loa Loa (eye worm) RNA binding protein 0.0198 0.0447 0.1929
Mycobacterium tuberculosis Conserved protein 0.0154 0.034 0.1415
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0002 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0046 0.0094
Brugia malayi nuclear receptor NHR-88 0.0031 0.0042 0.0181
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0026 0.0053
Echinococcus granulosus dna polymerase eta 0.0064 0.0121 0.0245

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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