Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0026 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.8593 | 0.8593 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.8593 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.8593 | 0.8593 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 0.5 |
Brugia malayi | hypothetical protein | 0.0016 | 0.1458 | 0.1458 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8593 | 0.5 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.8593 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9606 | 0.9606 |
Echinococcus multilocularis | musashi | 0.0026 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.8593 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8593 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.