Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0027 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9606 | 0.9606 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.8593 | 0.8593 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.8593 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.8593 | 0.8593 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.8593 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8593 | 0.5 |
Brugia malayi | hypothetical protein | 0.0016 | 0.1458 | 0.1458 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.8593 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8593 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.