Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0061884 | 1 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.00350502 | 0 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0061884 | 1 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0061884 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0061884 | 1 | 0.5 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0061884 | 1 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.00350502 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.00350502 | 0 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0061884 | 1 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0061884 | 1 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.00350502 | 0 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.00350502 | 0 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0061884 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.00350502 | 0 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.00350502 | 0 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0061884 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0061884 | 1 | 0.5 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0061884 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.00350502 | 0 | 0.5 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0061884 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.00350502 | 0 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.00350502 | 0 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.00350502 | 0 | 0.5 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0061884 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.432 | Antileishmanial activity against Leishmania donovani | ChEMBL. | 20728249 |
IC50 (functional) | = 3.7 uM | Inhibitory concentration against Leishmania donovani axenic amastigotes was determined in vitro | ChEMBL. | 15027874 |
IC50 (functional) | = 3.7 uM | Inhibitory concentration against Leishmania donovani axenic amastigotes was determined in vitro | ChEMBL. | 15027874 |
IC50 (functional) | = 4 uM | Antimicrobial activity against Leishmania donovani | ChEMBL. | 20185316 |
IC50 (functional) | = 5.1 uM | In vitro cytotoxicity against mouse J774 macrophages. | ChEMBL. | 15027874 |
IC50 (functional) | = 5.1 uM | In vitro cytotoxicity against mouse J774 macrophages. | ChEMBL. | 15027874 |
IC50 (binding) | = 5.8 uM | Inhibition of Leishmanial tubulin assembly | ChEMBL. | 15027874 |
IC50 (functional) | = 8 uM | Inhibitory concentration against brucei variant 221 was determined in vitro | ChEMBL. | 15027874 |
IC50 (functional) | = 8 uM | Inhibitory concentration against brucei variant 221 was determined in vitro | ChEMBL. | 15027874 |
IC50 (functional) | = 8 uM | Antimicrobial activity against Trypanosoma brucei brucei | ChEMBL. | 20185316 |
IC50 (functional) | = 11 uM | In vitro cytotoxicity against mouse PC3 prostate cancer cell line. | ChEMBL. | 15027874 |
IC50 (functional) | = 11 uM | In vitro cytotoxicity against mouse PC3 prostate cancer cell line. | ChEMBL. | 15027874 |
Inhibition (binding) | < 20 % | Inhibition of porcine brain tubulin assembly at 40 uM | ChEMBL. | 15027874 |
Inhibition (binding) | < 20 % | Inhibition of porcine brain tubulin assembly at 40 uM | ChEMBL. | 15027874 |
Inhibition (binding) | = 102 % | Inhibition percentage of Leishmanial tubulin assembly at a concentration of 10 uM. | ChEMBL. | 15027874 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 15027874 | ||
Mus musculus | ChEMBL23 | 15027874 | |
Trypanosoma brucei | ChEMBL23 | 15027874 | |
Homo sapiens | ChEMBL23 | 15027874 | |
Leishmania donovani | ChEMBL23 | 15027874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.