Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0199 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7956 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3599 | 0.3469 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0199 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0199 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0199 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0851 | 0.0914 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0333 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4357 | 0.4709 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0199 | 0.0215 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0851 | 0.084 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0851 | 0.0914 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0518 | 0.0411 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0199 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0199 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0199 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0199 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3186 | 0.4188 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0518 | 0.0559 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.1264 | 0.1086 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3186 | 0.4188 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0199 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0333 | 0.0188 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7332 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0333 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4024 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3611 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9254 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0199 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7332 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0199 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.