Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.001 | 0.5774 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.001 | 0.5774 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0008 | 0.4068 | 0.4068 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.001 | 0.5774 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0008 | 0.4068 | 0.4068 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.001 | 0.5774 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.001 | 0.5774 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.001 | 0.5774 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.001 | 0.5774 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.001 | 0.5774 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.001 | 0.5774 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.001 | 0.5774 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.001 | 0.5774 | 0.5774 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.001 | 0.5774 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.001 | 0.5774 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.001 | 0.5774 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.001 | 0.5774 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.001 | 0.5774 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.001 | 0.5774 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.001 | 0.5774 | 0.2876 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.001 | 0.5774 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0008 | 0.4068 | 0.4068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.