Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0053 | 0.0643 | 0.0632 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0095 | 0.0084 |
Mycobacterium ulcerans | epimerase | 0.0021 | 0.02 | 0.005 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.061 | 0.06 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0061 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.3364 | 0.9088 |
Mycobacterium ulcerans | NADH dehydrogenase | 0.0053 | 0.0643 | 0.1824 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0445 | 0.0286 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0187 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0351 | 0.0919 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0325 | 0.0849 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0726 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.02 | 0.0031 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0445 | 0.0646 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1538 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0187 | 0.0476 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0053 | 0.0643 | 0.1711 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0053 | 0.0643 | 0.0505 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0116 | 0.0283 |
Schistosoma mansoni | hypothetical protein | 0.043 | 0.5888 | 0.5884 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0061 | 0.005 |
Echinococcus granulosus | lamin | 0.0028 | 0.0299 | 0.0288 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0299 | 0.0288 |
Plasmodium falciparum | glutathione reductase | 0.0273 | 0.3701 | 1 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0053 | 0.0643 | 0.1141 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.02 | 0.2685 | 1 |
Onchocerca volvulus | 0.0051 | 0.061 | 0.1292 | |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0053 | 0.0643 | 0.0882 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase-like protein, putative | 0.0053 | 0.0643 | 0.0505 |
Plasmodium vivax | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0081 | 0.1026 | 0.2016 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0187 | 0.0096 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0053 | 0.0643 | 0.1538 |
Trypanosoma brucei | trypanothione reductase | 0.0273 | 0.3701 | 0.3953 |
Trypanosoma brucei | NADH dehydrogenase | 0.0053 | 0.0643 | 0.0596 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0299 | 0.078 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0095 | 0.0084 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 0.3364 | 0.3356 |
Schistosoma mansoni | glutamate synthase | 0.0053 | 0.0643 | 0.0632 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0053 | 0.0643 | 0.1538 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0494 | 0.0483 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0025 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0187 | 0.0476 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0187 | 0.0096 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0147 | 0.1947 | 0.5247 |
Echinococcus multilocularis | dnaJ subfamily B | 0.043 | 0.5888 | 0.5884 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0445 | 0.0286 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.0643 | 0.1824 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0053 | 0.0643 | 0.0872 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0445 | 0.1065 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.02 | 0.2685 | 0.2769 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0053 | 0.0643 | 0.0505 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.02 | 0.2685 | 0.2677 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0053 | 0.0643 | 0.1711 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0299 | 0.0288 |
Onchocerca volvulus | 0.0032 | 0.0351 | 0.0475 | |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.02 | 0.2685 | 0.2769 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0025 | 0.0014 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.02 | 0.2685 | 0.6968 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.02 | 0.2685 | 0.6679 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0053 | 0.0643 | 0.0872 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0487 | 0.667 | 0.6666 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0051 | 0.0039 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Onchocerca volvulus | 0.0028 | 0.0299 | 0.0313 | |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase fadh1, putative | 0.0053 | 0.0643 | 0.0505 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0351 | 0.034 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0445 | 0.1065 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0187 | 0.0448 |
Mycobacterium ulcerans | hypothetical protein | 0.0021 | 0.02 | 0.005 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0162 | 0.2157 | 0.491 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.02 | 0.2685 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.2685 | 0.7247 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0273 | 0.3701 | 0.3693 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0061 | 0.0134 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0497 | 0.6813 | 0.737 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0273 | 0.3701 | 1 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0053 | 0.0643 | 0.1824 |
Mycobacterium tuberculosis | Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) | 0.0053 | 0.0643 | 0.1136 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0445 | 0.0286 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0061 | 0.005 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0187 | 0.0176 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0445 | 0.0434 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0351 | 0.034 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0053 | 0.0643 | 0.0872 |
Brugia malayi | Hypothetical 29.7 kDa protein C05D11.5 in chromosome III | 0.0021 | 0.02 | 0.051 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0187 | 0.0476 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.0444 | 0.0433 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0187 | 0.0176 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.02 | 0.051 |
Brugia malayi | Pre-SET motif family protein | 0.022 | 0.2959 | 0.7988 |
Echinococcus multilocularis | glutamate synthase | 0.0053 | 0.0643 | 0.0632 |
Mycobacterium ulcerans | glutamate synthase subunit beta | 0.0053 | 0.0643 | 0.1824 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.02 | 0.2685 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.0409 | 0.0978 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0299 | 0.0288 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0349 | 0.0338 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0445 | 0.0379 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0053 | 0.0643 | 0.1141 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0049 | 0.0102 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0669 | 0.9209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0373 | 0.098 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0053 | 0.0643 | 0.1141 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0051 | 0.0039 |
Trypanosoma brucei | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0053 | 0.0643 | 0.0596 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0351 | 0.034 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0187 | 0.0096 |
Plasmodium vivax | glutathione reductase, putative | 0.0273 | 0.3701 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0053 | 0.0643 | 0.1141 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0643 | 0.0505 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0053 | 0.0643 | 0.0632 |
Echinococcus granulosus | geminin | 0.0178 | 0.2384 | 0.2375 |
Brugia malayi | glutathione reductase | 0.0273 | 0.3701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0292 | 0.076 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0487 | 0.667 | 0.6666 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0445 | 0.0434 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0299 | 0.078 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0187 | 0.0176 |
Mycobacterium leprae | Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) | 0.0053 | 0.0643 | 0.1108 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.02 | 0.2685 | 0.2677 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0008 | 0.0012 | 0.0028 |
Toxoplasma gondii | selenide, water dikinase | 0.0053 | 0.0643 | 0.0872 |
Trichomonas vaginalis | set domain proteins, putative | 0.025 | 0.3379 | 0.8083 |
Onchocerca volvulus | 0.003 | 0.0325 | 0.0394 | |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0187 | 0.0176 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.0444 | 0.1173 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.02 | 0.2685 | 1 |
Toxoplasma gondii | endonuclease IV APN | 0.0081 | 0.1026 | 0.2016 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0308 | 0.418 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0187 | 0.0476 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.0053 | 0.0643 | 0.1136 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.2384 | 0.2375 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0566 | 0.7774 | 0.8409 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0445 | 0.1175 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0187 | 0.0096 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0025 | 0.0014 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.02 | 0.2685 | 0.2769 |
Plasmodium vivax | NAD(P)H-dependent glutamate synthase, putative | 0.0053 | 0.0643 | 0.0872 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.02 | 0.2685 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.0053 | 0.0643 | 0.1108 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0061 | 0.005 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0309 | 0.4199 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.02 | 0.2685 | 0.6255 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0643 | 0.0505 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0566 | 0.7774 | 0.8409 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0053 | 0.0643 | 0.1538 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0187 | 0.0096 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0299 | 0.0288 |
Leishmania major | trypanothione reductase | 0.0273 | 0.3701 | 0.3894 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0445 | 0.1033 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.015 | 0.1993 | 0.7231 |
Mycobacterium ulcerans | NADPH dependent 2,4-dienoyl-CoA reductase FadH | 0.0053 | 0.0643 | 0.1824 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0299 | 0.0288 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.061 | 0.1623 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 0.3364 | 0.3356 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.015 | 0.1993 | 0.4502 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0349 | 0.0338 |
Plasmodium vivax | ferrodoxin reductase, putative | 0.0053 | 0.0643 | 0.0872 |
Onchocerca volvulus | 0.0028 | 0.0299 | 0.0313 | |
Toxoplasma gondii | NADH dehydrogenase (NDH2-II) | 0.0053 | 0.0643 | 0.0872 |
Mycobacterium tuberculosis | Probable reductase | 0.0162 | 0.2157 | 0.491 |
Trichomonas vaginalis | mercuric reductase, putative | 0.02 | 0.2685 | 0.6423 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0053 | 0.0643 | 0.0632 |
Echinococcus multilocularis | geminin | 0.0178 | 0.2384 | 0.2375 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0299 | 0.078 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Treponema pallidum | NADH oxidase | 0.02 | 0.2685 | 0.5773 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.02 | 0.2685 | 0.2677 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0351 | 0.034 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1538 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0497 | 0.6813 | 0.7345 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1026 | 0.275 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0349 | 0.0338 |
Plasmodium falciparum | thioredoxin reductase | 0.0273 | 0.3701 | 1 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0053 | 0.0643 | 0.1711 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Schistosoma mansoni | glutamate synthase | 0.0053 | 0.0643 | 0.0632 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0351 | 0.034 |
Echinococcus granulosus | glutamate synthase | 0.0053 | 0.0643 | 0.0632 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0053 | 0.0643 | 0.0505 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0162 | 0.2157 | 0.491 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0669 | 0.9209 | 1 |
Mycobacterium ulcerans | ferredoxin reductase | 0.0053 | 0.0643 | 0.1824 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0162 | 0.2157 | 0.491 |
Leishmania major | 2,4-dienoyl-coa reductase-like protein | 0.0053 | 0.0643 | 0.0505 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0187 | 0.0176 |
Brugia malayi | hypothetical protein | 0.0249 | 0.3364 | 0.9088 |
Chlamydia trachomatis | endonuclease IV | 0.0081 | 0.1026 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0088 | 0.0207 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0566 | 0.7774 | 0.8409 |
Echinococcus granulosus | neuropeptide s receptor | 0.0487 | 0.667 | 0.6666 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0349 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0088 | 0.0207 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.02 | 0.2685 | 0.2838 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.02 | 0.2685 | 0.6968 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0061 | 0.005 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0053 | 0.0643 | 0.0632 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0053 | 0.0643 | 0.1711 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0497 | 0.6813 | 0.7345 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0309 | 0.4199 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1538 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0643 | 0.0505 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0053 | 0.0643 | 0.0596 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0053 | 0.0643 | 0.0505 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0053 | 0.0643 | 0.1141 |
Mycobacterium tuberculosis | Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) | 0.0053 | 0.0643 | 0.1136 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.061 | 0.06 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0053 | 0.0643 | 0.0632 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0053 | 0.0643 | 0.0596 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0162 | 0.2157 | 0.491 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0008 | 0.0012 | 0.0028 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0726 | 1 | 1 |
Mycobacterium leprae | PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) | 0.0081 | 0.1026 | 0.2066 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.2384 | 0.2375 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0309 | 0.4199 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0325 | 0.0849 |
Mycobacterium leprae | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0053 | 0.0643 | 0.1108 |
Mycobacterium tuberculosis | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) | 0.0081 | 0.1026 | 0.2091 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.0717 | 0.1093 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.022 | 0.2959 | 0.7988 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh1 | 0.0053 | 0.0643 | 0.1824 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1538 |
Schistosoma mansoni | lamin | 0.0028 | 0.0299 | 0.0288 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0116 | 0.0283 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.0444 | 0.1173 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0566 | 0.7774 | 0.8424 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Mycobacterium tuberculosis | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0053 | 0.0643 | 0.1136 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0389 | 0.0472 |
Schistosoma mansoni | sulfide quinone reductase | 0.0053 | 0.0643 | 0.0632 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.02 | 0.2685 | 0.6968 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0643 | 0.0632 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0053 | 0.0643 | 0.0596 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0051 | 0.0106 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0487 | 0.667 | 0.6666 |
Plasmodium falciparum | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0081 | 0.1026 | 0.1254 |
Leishmania major | 2,4-dienoyl-coa reductase fadh1, putative | 0.0053 | 0.0643 | 0.0505 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0053 | 0.0643 | 0.0632 |
Mycobacterium ulcerans | monoxygenase | 0.0053 | 0.0643 | 0.1824 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0445 | 0.1175 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0187 | 0.0176 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0445 | 0.1065 |
Plasmodium falciparum | glutathione reductase | 0.02 | 0.2685 | 0.6679 |
Loa Loa (eye worm) | glutathione reductase | 0.0273 | 0.3701 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0325 | 0.0314 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0669 | 0.9209 | 1 |
Mycobacterium leprae | PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) | 0.0053 | 0.0643 | 0.1108 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.0812 | 0.0801 |
Wolbachia endosymbiont of Brugia malayi | NADPH-dependent glutamate synthase beta chain | 0.0053 | 0.0643 | 0.0882 |
Brugia malayi | glutamate synthase | 0.0053 | 0.0643 | 0.1711 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0162 | 0.2157 | 0.491 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0643 | 0.1711 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0053 | 0.0643 | 0.0505 |
Schistosoma mansoni | lamin | 0.0028 | 0.0299 | 0.0288 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0445 | 0.0434 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0187 | 0.0176 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0053 | 0.0643 | 0.1538 |
Trypanosoma brucei | 2,4-dienoyl-coa reductase-like protein | 0.0053 | 0.0643 | 0.0596 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0351 | 0.034 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0445 | 0.0282 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0025 | 0.0014 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.02 | 0.2685 | 0.2769 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0061 | 0.005 |
Mycobacterium tuberculosis | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) | 0.0053 | 0.0643 | 0.1136 |
Schistosoma mansoni | glutamate synthase | 0.0053 | 0.0643 | 0.0632 |
Plasmodium vivax | type II NADH:ubiquinone oxidoreductase, putative | 0.0053 | 0.0643 | 0.0872 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0445 | 0.0434 |
Giardia lamblia | Glutamate synthase | 0.0053 | 0.0643 | 0.1141 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0273 | 0.3701 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0162 | 0.2157 | 0.4894 |
Mycobacterium tuberculosis | Possible dehydrogenase/reductase | 0.0053 | 0.0643 | 0.1136 |
Schistosoma mansoni | sulfide quinone reductase | 0.0053 | 0.0643 | 0.0632 |
Mycobacterium ulcerans | endonuclease IV | 0.0081 | 0.1026 | 0.3359 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Brugia malayi | DNA-(Apurinic or apyrimidinic site) lyase | 0.0081 | 0.1026 | 0.275 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0053 | 0.0643 | 0.0882 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0053 | 0.0643 | 0.1824 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0053 | 0.0643 | 0.1538 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0351 | 0.034 |
Echinococcus granulosus | dnaJ subfamily B | 0.043 | 0.5888 | 0.5884 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.015 | 0.1993 | 0.4485 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0053 | 0.0643 | 0.0632 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.02 | 0.2685 | 0.6226 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.0409 | 0.0978 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0389 | 0.0502 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.02 | 0.2685 | 1 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprB | 0.0053 | 0.0643 | 0.1824 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0053 | 0.0643 | 0.1141 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0273 | 0.3701 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0273 | 0.3701 | 0.3894 |
Onchocerca volvulus | 0.0053 | 0.0643 | 0.1394 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 0.418 | 1 |
Mycobacterium ulcerans | sugar phosphate isomerases/epimerases | 0.0021 | 0.02 | 0.005 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1141 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0669 | 0.9209 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.02 | 0.2685 | 0.6679 |
Giardia lamblia | Thioredoxin reductase | 0.0053 | 0.0643 | 0.1141 |
Toxoplasma gondii | non-proton pumping type-II NADH dehydrogenase I | 0.0053 | 0.0643 | 0.0872 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0494 | 0.0483 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0053 | 0.0643 | 0.1711 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1538 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0273 | 0.3701 | 0.3693 |
Trypanosoma cruzi | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0053 | 0.0643 | 0.0505 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh | 0.0053 | 0.0643 | 0.1824 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0299 | 0.078 |
Trichomonas vaginalis | glutathione reductase, putative | 0.02 | 0.2685 | 0.6423 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0053 | 0.0643 | 0.1538 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0308 | 0.418 | 1 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0053 | 0.0643 | 0.0505 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0497 | 0.6813 | 0.7345 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0053 | 0.0643 | 0.1538 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0095 | 0.0227 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0053 | 0.0643 | 0.1538 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0187 | 0.0448 |
Plasmodium falciparum | thioredoxin reductase | 0.02 | 0.2685 | 0.6679 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0025 | 0.0014 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0309 | 0.4199 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0187 | 0.0176 |
Onchocerca volvulus | 0.025 | 0.3379 | 1 | |
Mycobacterium ulcerans | dehydrogenase | 0.0053 | 0.0643 | 0.1824 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.02 | 0.2685 | 0.6968 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0273 | 0.3701 | 0.8757 |
Toxoplasma gondii | thioredoxin reductase | 0.0273 | 0.3701 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0187 | 0.0096 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.0053 | 0.0643 | 0.1824 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0147 | 0.1947 | 0.5247 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0351 | 0.0919 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0061 | 0.0134 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0325 | 0.0314 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.0444 | 0.0433 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0299 | 0.078 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0299 | 0.0288 |
Leishmania major | NADH dehydrogenase, putative | 0.0053 | 0.0643 | 0.0505 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0053 | 0.0643 | 0.1141 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 50 mg kg-1 | Compound was tested for antifungal activity by measuring systemic candidosis in mice on 7th day upon single peroral administration | ChEMBL. | 9873441 |
ED50 (functional) | = 50 mg kg-1 | Compound was tested for antifungal activity by measuring systemic candidosis in mice on 7th day upon single peroral administration | ChEMBL. | 9873441 |
IC80 (functional) | = 0.08 ug ml-1 | Compound was tested for in vitro antifungal activity against Candida albicans (CY3003) | ChEMBL. | 9873441 |
IC80 (functional) | = 0.08 ug ml-1 | Compound was tested for in vitro antifungal activity against Candida albicans (CY3003) | ChEMBL. | 9873441 |
IC80 (functional) | = 0.24 ug ml-1 | Compound was tested for in vitro antifungal activity against Candida neoformans (CY1057) | ChEMBL. | 9873441 |
IC80 (functional) | = 0.24 ug ml-1 | Compound was tested for in vitro antifungal activity against Candida neoformans (CY1057) | ChEMBL. | 9873441 |
IC80 (functional) | = 84 ug ml-1 | Compound was tested in vitro for antifungal activity against Aspergillus fumigatus (CF1003) | ChEMBL. | 9873441 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.