TDR Targets

Basic information

Technical information

TDR Targets ID: 777043
Name: 4-chloro-3-methyl-N-(2-morpholin-4-ylethyl)be nzenesulfonamide
MW: 318.82 | Formula: C13H19ClN2O3S
H donors: 1 H acceptors: 2 LogP: 1.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1C)S(=O)(=O)NCCN1CCOCC1
InChi: 1S/C13H19ClN2O3S/c1-11-10-12(2-3-13(11)14)20(17,18)15-4-5-16-6-8-19-9-7-16/h2-3,10,15H,4-9H2,1H3
InChiKey: OGAUZDNYWAOXIX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-chloro-3-methyl-N-(2-morpholinoethyl)benzenesulfonamide
4-chloro-3-methyl-N-[2-(4-morpholinyl)ethyl]benzenesulfonamide
AP-263/11224286
EU-0015626
STOCK3S-23432

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0429	0.0618
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0101	0.2783	1
Brugia malayi	hypothetical protein	0.0232	0.6949	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2442	0.487
Echinococcus granulosus	geminin	0.0168	0.4926	0.4926
Echinococcus granulosus	intermediate filament protein	0.0026	0.0429	0.0429
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1099	0.1527
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.2442	0.3514
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1122	0.1614
Echinococcus multilocularis	musashi	0.0026	0.0429	0.0429
Schistosoma mansoni	hypothetical protein	0.0035	0.0704	0.128
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0085	0.0122
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2783	1
Onchocerca volvulus		0.0048	0.1122	0.2354
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.2442	0.3473
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0085	0.0085
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0085	0.0085
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0704	0.128
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1134	0.1578
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1134	0.1578
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0101	0.2783	1
Echinococcus multilocularis	geminin	0.0168	0.4926	0.4926
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0429	0.0712
Brugia malayi	Inositol-1	0.0073	0.1902	0.269
Echinococcus granulosus	lamin dm0	0.0026	0.0429	0.0429
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1134	0.1632
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0101	0.2783	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0085	0.0122
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0101	0.2783	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0085	0.0085
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2783	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0648	0.0933
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0414	0.0596
Echinococcus multilocularis	tumor protein p63	0.0329	1	1
Schistosoma mansoni	inositol monophosphatase	0.0073	0.1902	0.3753
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0101	0.2783	1
Loa Loa (eye worm)	inositol-1	0.0073	0.1902	0.2737
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.3266	0.47
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0648	0.0875
Trypanosoma brucei	protein kinase, putative	0.0101	0.2783	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2442	0.2442
Brugia malayi	MAP kinase sur-1	0.0101	0.2783	0.3967
Echinococcus granulosus	GPCR family 2	0.0015	0.0085	0.0085
Echinococcus granulosus	inositol monophosphatase 1	0.0073	0.1902	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0232	0.6949	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.337	0.485
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0073	0.1902	0.5
Schistosoma mansoni	inositol monophosphatase	0.0073	0.1902	0.3753
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0704	0.0704
Brugia malayi	follicle stimulating hormone receptor	0.0232	0.6942	0.999
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2442	0.2442
Echinococcus multilocularis	lamin dm0	0.0026	0.0429	0.0429
Brugia malayi	intermediate filament protein	0.0026	0.0429	0.0558
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0101	0.2783	0.2783
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0073	0.1902	0.5
Echinococcus granulosus	mitogen activated protein kinase	0.0101	0.2783	0.2783
Schistosoma mansoni	hypothetical protein	0.0168	0.4926	1
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2783	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0232	0.6942	0.999
Brugia malayi	hypothetical protein	0.0035	0.0704	0.0956
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0044	0.0063
Trichomonas vaginalis	CMGC family protein kinase	0.0101	0.2783	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.3266	0.47
Schistosoma mansoni	hypothetical protein	0.0033	0.0648	0.1164
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0101	0.2783	1
Schistosoma mansoni	lamin	0.0026	0.0429	0.0712
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0429	0.0618
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.1122	0.2142
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2442	0.487
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0085	0.0059
Onchocerca volvulus	Huntingtin homolog	0.0119	0.337	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0085	0.0059
Echinococcus granulosus	lamin	0.0026	0.0429	0.0429
Schistosoma mansoni	lamin	0.0026	0.0429	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1134	0.1632
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0065	0.166	0.5
Echinococcus multilocularis	inositol monophosphatase 1	0.0073	0.1902	0.1902
Giardia lamblia	Kinase, CMGC MAPK	0.0101	0.2783	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2442	0.487
Onchocerca volvulus	Huntingtin homolog	0.0119	0.337	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0101	0.2783	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2442	0.2442
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.6949	0.6949
Brugia malayi	MH2 domain containing protein	0.0116	0.3266	0.4666
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0101	0.2783	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0101	0.2783	0.2783
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0429	0.0558
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0101	0.2783	0.4005
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0073	0.1902	1
Onchocerca volvulus		0.0047	0.1099	0.2275
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0429	0.0618
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0065	0.166	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.2783	0.5574
Schistosoma mansoni	hypothetical protein	0.0168	0.4926	1
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.6949	0.6949
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0704	0.0704
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1099	0.2094
Schistosoma mansoni	hypothetical protein	0.0047	0.1099	0.2094
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2442	0.2442
Echinococcus multilocularis	lamin	0.0026	0.0429	0.0429
Echinococcus multilocularis	mitogen activated protein kinase	0.0101	0.2783	0.2783
Loa Loa (eye worm)	hypothetical protein	0.0119	0.337	0.485
Brugia malayi	hypothetical protein	0.0119	0.337	0.4817

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 777043