Detailed information for compound 777409

Basic information

Technical information
  • TDR Targets ID: 777409
  • Name: 4-[5-(2-oxo-2-piperidin-1-ylethyl)sulfanyltet razol-1-yl]benzamide
  • MW: 346.407 | Formula: C15H18N6O2S
  • H donors: 1 H acceptors: 5 LogP: 1.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCC1)CSc1nnnn1c1ccc(cc1)C(=O)N
  • InChi: 1S/C15H18N6O2S/c16-14(23)11-4-6-12(7-5-11)21-15(17-18-19-21)24-10-13(22)20-8-2-1-3-9-20/h4-7H,1-3,8-10H2,(H2,16,23)
  • InChiKey: QCRXJQVCYIEJQN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[5-[2-oxo-2-(1-piperidyl)ethyl]sulfanyltetrazol-1-yl]benzamide
  • 4-[5-[[2-oxo-2-(1-piperidyl)ethyl]thio]-1-tetrazolyl]benzamide
  • 4-[5-[(2-keto-2-piperidino-ethyl)thio]tetrazol-1-yl]benzamide
  • 4-[5-(2-oxo-2-piperidin-1-yl-ethyl)sulfanyl-1,2,3,4-tetrazol-1-yl]benzamide
  • Oprea1_502871
  • Oprea1_856816
  • ZINC04321034
  • 4-[5-(2-Oxo-2-piperidin-1-yl-ethylsulfanyl)-tetrazol-1-yl]-benzamide
  • BAS 03818813
  • ST056811

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0094 0.1377 0.3274
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.1009 0.1009
Brugia malayi Carboxylesterase family protein 0.0109 0.1613 0.1613
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0109 0.1613 0.1613
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.003 0.0369 0.0369
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus granulosus roundabout 2 0.001 0.0061 0.0061
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0009 0.0052 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi G-protein coupled receptor 0.0071 0.1009 0.1009
Schistosoma mansoni amine GPCR 0.0071 0.1009 0.1009
Echinococcus granulosus acetylcholinesterase 0.0647 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Schistosoma mansoni hypothetical protein 0.011 0.1618 0.1618
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0101 0.0101
Echinococcus granulosus g-protein coupled receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis tar DNA binding protein 0.0041 0.0547 0.0547
Echinococcus granulosus tachykinin peptides receptor 99D 0.0071 0.1009 0.1009
Loa Loa (eye worm) carboxylesterase 0.0109 0.1613 0.1613
Schistosoma mansoni glutamate receptor AMPA 0.0006 0.0003 0.0003
Schistosoma mansoni neuropeptide receptor 0.0071 0.1009 0.1009
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0101 0.0264
Schistosoma mansoni neuropeptide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis neuroglian 0.0007 0.0023 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.1009 0.1009
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.1377 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0369 0.0369
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.1009 0.1009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.1009 0.1009
Schistosoma mansoni neuropeptide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis nmda type glutamate receptor 0.0022 0.0248 0.0248
Schistosoma mansoni ATP-binding cassette transporter 0.0006 0.0003 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Schistosoma mansoni vesicular amine transporter 0.0007 0.0023 0.0023
Schistosoma mansoni glutamate receptor kainate 0.0006 0.0003 0.0003
Echinococcus multilocularis neuroligin 0.0109 0.1613 0.1613
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.1009 0.1009
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0547 0.0547
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.1009 0.1009
Schistosoma mansoni opsin-like receptor 0.0071 0.1009 0.1009
Echinococcus granulosus para nitrobenzyl esterase 0.0109 0.1613 0.1613
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.1377 0.3274
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus granulosus neuropeptide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0009 0.0052 0.0052
Schistosoma mansoni glutamate receptor kainate 0.0006 0.0003 0.0003
Schistosoma mansoni acetylcholinesterase 0.0109 0.1613 0.1613
Schistosoma mansoni hypothetical protein 0.0071 0.1009 0.1009
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0016 0.0152 0.0582
Schistosoma mansoni glutamate receptor AMPA 0.0006 0.0003 0.0003
Plasmodium falciparum acyl-CoA synthetase 0.0009 0.0052 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0647 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0262 0.3997 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0071 0.1009 0.1009
Echinococcus granulosus neuropeptide s receptor 0.0071 0.1009 0.1009
Schistosoma mansoni hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0369 0.0369
Brugia malayi Dopamine receptor protein 2 0.0071 0.1009 0.1009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0369 0.0369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.1009 0.1009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.1009 0.1009
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0006 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0101 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.1009 0.1009
Brugia malayi hypothetical protein 0.0007 0.0023 0.0023
Echinococcus granulosus g protein coupled receptor 0.0071 0.1009 0.1009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0071 0.0071
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.1009 0.1009
Echinococcus granulosus g protein coupled receptor 0.0071 0.1009 0.1009
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0049 0.0668 0.0668
Schistosoma mansoni amine GPCR 0.0071 0.1009 0.1009
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0128 0.1905 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0043 0.0576 0.0576
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.1009 0.1009
Schistosoma mansoni BC026374 protein (S09 family) 0.0109 0.1613 0.1613
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0006 0.0003 0.0003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Brugia malayi GnHR receptor homolog 0.0071 0.1009 0.1009
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0071 0.1009 0.1009
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.1377 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.1009 0.1009
Leishmania major 4-coumarate:coa ligase-like protein 0.0012 0.0101 0.0733
Echinococcus multilocularis roundabout 2 0.001 0.0061 0.0061
Echinococcus multilocularis orexin receptor type 2 0.0071 0.1009 0.1009
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0101 0.0101
Onchocerca volvulus 0.0109 0.1613 1
Echinococcus multilocularis carboxylesterase 5A 0.0647 1 1
Entamoeba histolytica hypothetical protein 0.0094 0.1377 0.3274
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.1009 0.1009
Schistosoma mansoni myosin xvIII 0.0071 0.1009 0.1009
Schistosoma mansoni amine GPCR 0.0071 0.1009 0.1009
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0128 0.1905 1
Chlamydia trachomatis glutamine binding protein 0.0016 0.0152 1
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.1009 0.1009
Schistosoma mansoni hypothetical protein 0.0006 0.0003 0.0003
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.1009 0.1009
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0006 0.0003 0.0003
Schistosoma mansoni neuroligin 3 (S09 family) 0.0109 0.1613 0.1613
Brugia malayi Serotonin receptor 0.0071 0.1009 0.1009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus granulosus Immunoglobulin 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.1009 0.6004
Brugia malayi hypothetical protein 0.0109 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0012 0.0099 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0547 0.0547
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0109 0.1613 0.8428
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis glutamate receptor 2 0.0009 0.0052 0.0052
Echinococcus multilocularis glutamate receptor 2 0.0006 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.011 0.1618 0.1618
Onchocerca volvulus 0.0071 0.1009 0.6004
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0011 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0101
Brugia malayi Glutamate receptor 2 precursor 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Schistosoma mansoni hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi larval opioid receptor 0.0071 0.1009 0.1009
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.1009 0.1009
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus neuropeptide receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Schistosoma mansoni amine GPCR 0.0071 0.1009 0.1009
Echinococcus granulosus neuroglian 0.0007 0.0023 0.0023
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0101 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0547 0.0547
Echinococcus granulosus carboxylesterase 5A 0.0647 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.1009 0.1009
Echinococcus granulosus g protein coupled receptor 0.0071 0.1009 0.1009
Brugia malayi RE15519p 0.0071 0.1009 0.1009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.1009 0.1009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0101 0.0305
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0006 0.0003 0.0003
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0009 0.0052 0.0052
Brugia malayi AKH receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0262 0.3997 1
Echinococcus granulosus acetylcholinesterase 0.0647 1 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0007 0.0023 0.0023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0128 0.1905 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.1377 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis fmrfamide receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0101
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis acetylcholinesterase 0.0647 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.1009 0.1009
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.1377 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Echinococcus multilocularis Immunoglobulin 0.0007 0.0023 0.0023
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0009 0.0052 0.0052
Schistosoma mansoni biogenic amine receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.1009 0.1009
Echinococcus granulosus defective proboscis extension response 0.0007 0.0023 0.0023
Echinococcus multilocularis somatostatin receptor 0.0071 0.1009 0.1009
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.001 0.0061 0.0061
Brugia malayi G protein-coupled receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.1009 0.1009
Schistosoma mansoni gliotactin 0.0109 0.1613 0.1613
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus multilocularis para nitrobenzyl esterase 0.0109 0.1613 0.1613
Schistosoma mansoni hypothetical protein 0.0059 0.0824 0.0824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0094 0.1369 0.1369
Brugia malayi follicle stimulating hormone receptor 0.0071 0.1009 0.1009
Entamoeba histolytica protein kinase, putative 0.0094 0.1377 0.3274
Onchocerca volvulus 0.0109 0.1613 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.1377 0.1377
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.1009 0.1009
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.1009 0.1009
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi putative neuropeptide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis geminin 0.011 0.1618 0.1618
Brugia malayi sulfakinin receptor protein 0.0071 0.1009 0.1009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.1009 0.1009
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0101 0.0264
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.1009 0.1009
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis g protein coupled receptor 0.0071 0.1009 0.1009
Schistosoma mansoni nephrin 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Leishmania major 4-coumarate:coa ligase-like protein 0.0012 0.0101 0.0733
Echinococcus multilocularis Immunoglobulin 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0647 1 1
Echinococcus multilocularis g protein coupled receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0547 0.0547
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.1009 0.6004
Onchocerca volvulus 0.0109 0.1613 1
Echinococcus multilocularis serotonin receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) TAR-binding protein 0.0041 0.0547 0.0547
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0547 0.0547
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Trichomonas vaginalis spcc417.12 protein, putative 0.0109 0.1613 0.4034
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0109 0.1613 0.8428
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1377 0.1377
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus nmda type glutamate receptor 0.0022 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi Dopamine receptor 0.0071 0.1009 0.1009
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.1009 0.1009
Schistosoma mansoni amine GPCR 0.0071 0.1009 0.1009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0101 0.0264
Loa Loa (eye worm) carboxylesterase 0.0109 0.1613 0.1613
Brugia malayi Carboxylesterase family protein 0.0647 1 1
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis serotonin receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.1009 0.1009
Trypanosoma brucei RNA helicase, putative 0.0059 0.0824 0.5989
Loa Loa (eye worm) carboxylesterase 0.0647 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) glutamate receptor 1 0.0006 0.0003 0.0003
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0007 0.0023 0.0023
Echinococcus granulosus somatostatin receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.1009 0.1009
Echinococcus granulosus orexin receptor type 2 0.0071 0.1009 0.1009
Echinococcus granulosus twitchin 0.0008 0.0031 0.0031
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0009 0.0052 0.0052
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis sex peptide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.1009 0.1009
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0369 0.0369
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Echinococcus multilocularis neuropeptide receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.1009 0.1009
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0009 0.0052 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi RNA binding protein 0.0041 0.0547 0.0547
Echinococcus granulosus dual specificity 0.0094 0.1377 0.1377
Loa Loa (eye worm) hypothetical protein 0.0009 0.0052 0.0052
Schistosoma mansoni opsin-like receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Brugia malayi Protein kinase domain containing protein 0.0094 0.1377 0.1377
Echinococcus granulosus serotonin receptor 0.0071 0.1009 0.1009
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Echinococcus granulosus glutamate receptor 2 0.0009 0.0052 0.0052
Loa Loa (eye worm) glutamate receptor 2 0.0006 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0009 0.0052 0.0052
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0109 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0101
Loa Loa (eye worm) RNA binding protein 0.0041 0.0547 0.0547
Brugia malayi Glutamate receptor 1 precursor 0.0006 0.0003 0.0003
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0006 0.0003 0.0003
Echinococcus granulosus tar DNA binding protein 0.0041 0.0547 0.0547
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0009 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0052 0.0052
Brugia malayi neuropeptide F receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) acetylcholinesterase 1 0.0647 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0109 0.1613 0.8421
Echinococcus granulosus glutamate NMDA receptor subunit 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0369 0.0369
Onchocerca volvulus 0.0109 0.1613 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0012 0.0101 0.0305
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0109 0.1613 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0041 0.0547 0.0547
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0094 0.1369 0.1369
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0049 0.0668 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.1009 0.1009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0022 0.0248 0.0248
Echinococcus granulosus fmrfamide receptor 0.0071 0.1009 0.1009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0262 0.3997 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0012 0.0101 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0049 0.0668 0.1672
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0101 0.0264
Schistosoma mansoni neuropeptide receptor 0.0071 0.1009 0.1009
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.1009 0.1009
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0012 0.0101 0.0264
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.1009 0.1009
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.1009 0.1009
Schistosoma mansoni biogenic amine receptor 0.0071 0.1009 0.1009
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.1009 0.1009
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.1009 0.1009
Echinococcus multilocularis NMDA receptor 0.0006 0.0003 0.0003
Brugia malayi Fibronectin type III domain containing protein 0.0007 0.0023 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0009 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0265 0.404 0.404
Echinococcus granulosus sex peptide receptor 0.0071 0.1009 0.1009
Mycobacterium tuberculosis Carboxylesterase LipT 0.0109 0.1613 0.8428
Schistosoma mansoni glutamate receptor NMDA 0.0006 0.0003 0.0003
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0109 0.1613 0.4034
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.1009 0.1009
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Schistosoma mansoni cell adhesion molecule 0.001 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi Carboxylesterase family protein 0.0109 0.1613 0.1613
Brugia malayi ORL1-like opioid receptor 0.0071 0.1009 0.1009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.1009 0.1009
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.1009 0.1009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0668 0.0668
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.1009 0.1009
Brugia malayi neuropeptide F receptor 0.0071 0.1009 0.1009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.003 0.0369 0.0369
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.1009 0.1009
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0043 0.0576 0.0576
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.1009 0.1009
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus granulosus glutamate receptor subunit protein glur 0.0006 0.0003 0.0003
Schistosoma mansoni histamine h1 receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0369 0.0369
Schistosoma mansoni glutamate receptor NMDA 0.0009 0.0052 0.0052
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi Carboxylesterase family protein 0.0109 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Echinococcus granulosus neuroligin 0.0109 0.1613 0.1613
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.1009 0.1009
Brugia malayi G-protein coupled receptor 0.0071 0.1009 0.1009
Schistosoma mansoni opsin-like receptor 0.0071 0.1009 0.1009
Echinococcus granulosus allatostatin A receptor 0.0071 0.1009 0.1009
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.1009 0.1009
Schistosoma mansoni glutamate receptor kainate 0.0006 0.0003 0.0003
Onchocerca volvulus 0.0071 0.1009 0.6004
Brugia malayi Melatonin receptor type 1A 0.0071 0.1009 0.1009
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0109 0.1613 0.1613
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0016 0.0152 1
Onchocerca volvulus 0.0071 0.1009 0.6004
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0061
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0071 0.1009 0.6004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0109 0.1613 0.1613
Brugia malayi RNA recognition motif domain containing protein 0.0041 0.0547 0.0547
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0049 0.0668 0.0668
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Plasmodium vivax acyl-CoA synthetase, putative 0.0009 0.0052 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0262 0.3997 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0049 0.0668 0.0668
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.1009 0.1009
Schistosoma mansoni adenoreceptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.1009 0.1009
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.1009 0.1009
Echinococcus multilocularis fmrfamide receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0049 0.0668 0.0668
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi Dopamine receptor protein 1 0.0071 0.1009 0.1009
Mycobacterium ulcerans hypothetical protein 0.0012 0.0101 0.0264
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0043 0.0576 0.0576
Echinococcus multilocularis dual specificity 0.0094 0.1377 0.1377
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.1009 0.1009
Brugia malayi Serotonin receptor 0.0071 0.1009 0.1009
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.1009 0.1009
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0006 0.0003 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.1009 0.1009
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0043 0.0576 0.0576
Echinococcus granulosus geminin 0.011 0.1618 0.1618
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.1009 0.1009
Echinococcus multilocularis acetylcholinesterase 0.0647 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.1009 0.1009
Echinococcus multilocularis BC026374 protein (S09 family) 0.0109 0.1613 0.1613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Loa Loa (eye worm) hypothetical protein 0.0647 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0071 0.1009 0.1009
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0016 0.0152 0.0541
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0049 0.0668 0.0668
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Onchocerca volvulus 0.0109 0.1613 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.1009 0.1009
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.1009 0.1009
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0007 0.0023 0.0023
Echinococcus granulosus BC026374 protein S09 family 0.0109 0.1613 0.1613
Leishmania major 4-coumarate:coa ligase-like protein 0.0012 0.0101 0.0733
Echinococcus multilocularis g protein coupled receptor 0.0071 0.1009 0.1009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.1009 0.1009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0262 0.3997 1
Schistosoma mansoni biogenic amine receptor 0.0071 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0109 0.1613 0.1613
Brugia malayi TAR-binding protein 0.0041 0.0547 0.0547
Onchocerca volvulus 0.0071 0.1009 0.6004
Brugia malayi Carboxylesterase family protein 0.0109 0.1613 0.1613
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Brugia malayi hypothetical protein 0.0071 0.1009 0.1009
Echinococcus multilocularis allatostatin A receptor 0.0071 0.1009 0.1009

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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