Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | Inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 1 nM | Inhibitory concentration against Pneumocystis carinii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 1 nM | Inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 1 nM | Inhibitory concentration against Pneumocystis carinii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 2.4 nM | Inhibitory concentration against Mycobacterium avium dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 2.4 nM | Inhibitory concentration against Mycobacterium avium DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 2.4 nM | Inhibitory concentration against Mycobacterium avium dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 2.4 nM | Inhibitory concentration against Mycobacterium avium DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 34 nM | Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 34 nM | Inhibitory concentration against Toxoplasma gondii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 34 nM | Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 34 nM | Inhibitory concentration against Toxoplasma gondii DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 5000 nM | Inhibitory activity of the compound against rat dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 5000 nM | Inhibitory concentration of the compound against rat DHFR | ChEMBL. | 15974594 |
IC50 (binding) | = 5000 nM | Inhibitory activity of the compound against rat dihydrofolate reductase | ChEMBL. | 15026078 |
IC50 (binding) | = 5000 nM | Inhibitory concentration of the compound against rat DHFR | ChEMBL. | 15974594 |
Ratio (binding) | = 150 | Selectivity index was determined as ratio of IC50 against rat DHFR to that of IC50 against Toxoplasma gondii DHFR | ChEMBL. | 15026078 |
Ratio (binding) | = 2100 | Selectivity index was determined as ratio of IC50 against rat DHFR to that of IC50 against Mycobacterium avium DHFR | ChEMBL. | 15026078 |
Ratio (binding) | = 5000 | Selectivity index was determined as ratio of IC50 against rat DHFR to that of IC50 against Pneumocystis carinii DHFR | ChEMBL. | 15026078 |
Selectivity index (binding) | = 150 | Selectivity index measured as IC50(Rat)/IC50(T. gondii) | ChEMBL. | 15974594 |
Selectivity index (binding) | = 2100 | Selectivity index measured as IC50(Rat)/IC50(M. avium) | ChEMBL. | 15974594 |
Selectivity index (binding) | = 5000 | Selectivity index measured as IC50(Rat)/IC50(P. carnii) | ChEMBL. | 15974594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.