Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | References |
Candida albicans | myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) | Starlite/ChEMBL | No references |
Homo sapiens | N-myristoyltransferase 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | 0.0563 | 0.306 | 0.274 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0276 | 0.0256 | 0.023 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0534 | 0.2777 | 0.345 |
Brugia malayi | Peptidase family M13 containing protein | 0.1058 | 0.7904 | 0.7904 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.1948 | 0.1948 |
Leishmania major | N-myristoyl transferase, putative | 0.0648 | 0.3895 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0648 | 0.3895 | 0.3895 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0534 | 0.2777 | 0.345 |
Schistosoma mansoni | neprilysin | 0.0276 | 0.0256 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.1058 | 0.7904 | 0.7904 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0648 | 0.3895 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0648 | 0.3895 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.0256 | 0.023 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0648 | 0.3895 | 0.3991 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1058 | 0.7904 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0782 | 0.5203 | 0.5203 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1058 | 0.7904 | 0.7904 |
Loa Loa (eye worm) | hypothetical protein | 0.0782 | 0.5203 | 0.5203 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.1009 | 0.7426 | 0.7426 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1058 | 0.7904 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.1009 | 0.7426 | 0.9284 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0258 | 0.0076 | 0.0076 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0648 | 0.3895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0782 | 0.5203 | 0.5203 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.0256 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.0256 | 0.023 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.1009 | 0.7426 | 0.9284 |
Loa Loa (eye worm) | hypothetical protein | 0.0782 | 0.5203 | 0.5203 |
Onchocerca volvulus | 0.0563 | 0.306 | 1 | |
Brugia malayi | hypothetical protein | 0.0435 | 0.1808 | 0.1808 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0534 | 0.2777 | 0.345 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0648 | 0.3895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.5383 | 0.5383 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.0805 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0782 | 0.5203 | 0.5203 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.5383 | 0.5383 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0534 | 0.2777 | 0.345 |
Giardia lamblia | CDC72 | 0.0648 | 0.3895 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1058 | 0.7904 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0648 | 0.3895 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0648 | 0.3895 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0534 | 0.2777 | 0.345 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0446 | 0.1916 | 0.1916 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1058 | 0.7904 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.1058 | 0.7904 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1058 | 0.7904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1058 | 0.7904 | 0.7904 |
Loa Loa (eye worm) | hypothetical protein | 0.1058 | 0.7904 | 0.7904 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0648 | 0.3895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.5383 | 0.5383 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.0256 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2682 | 0.2682 |
Echinococcus granulosus | aminopeptidase N | 0.0563 | 0.306 | 0.274 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1058 | 0.7904 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0648 | 0.3895 | 0.3895 |
Trypanosoma brucei | N-myristoyltransferase | 0.0648 | 0.3895 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0563 | 0.306 | 0.306 |
Schistosoma mansoni | N-myristoyltransferase | 0.0648 | 0.3895 | 0.4879 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.5383 | 0.5383 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1272 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.0256 | 0.023 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.1009 | 0.7426 | 0.9389 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.5383 | 0.5383 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.5383 | 0.5383 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.0256 | 0.023 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0782 | 0.5203 | 0.5203 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0648 | 0.3895 | 0.3991 |
Brugia malayi | peptidase family M13 containing protein | 0.0258 | 0.0076 | 0.0076 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.176 | Inhibition of candida N-myristoyltransferase | ChEMBL. | No reference |
IC50 (binding) | = 1.5 uM | Inhibition of candida N-myristoyltransferase | ChEMBL. | No reference |
IC50 (binding) | = 15 uM | Inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) | ChEMBL. | 11459642 |
IC50 (binding) | = 15 uM | Inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) | ChEMBL. | 11459642 |
IC50 (functional) | = 53 uM | Antifungal activity against C. albicans CY1002 | ChEMBL. | 11459642 |
IC50 (functional) | = 53 uM | Antifungal activity against C. albicans CY1002 | ChEMBL. | 11459642 |
IC50 (binding) | > 550 uM | Inhibitory activity against human N-myristoyltransferase (HsNmt) | ChEMBL. | 11459642 |
IC50 (binding) | > 550 uM | Inhibitory activity against human N-myristoyltransferase (HsNmt) | ChEMBL. | 11459642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.