Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0883 | 0.0947 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0073 | 0.3853 | 0.4427 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2754 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0031 | 0.0607 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0031 | 0.0607 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.2754 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2754 | 0.2844 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.2754 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0073 | 0.3853 | 0.4427 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0607 | 0.2204 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.4237 | 0.4543 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.9327 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0121 | 0.7593 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2754 | 0.2844 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4609 | 0.4942 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0883 | 0.0366 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0046 | 0.1747 | 0.1287 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0121 | 0.7593 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0031 | 0.0607 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0046 | 0.1747 | 0.151 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0883 | 0.0366 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.4226 | 0.4226 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0036 | 0.0979 | 0.105 |
Schistosoma mansoni | bromodomain containing protein | 0.0129 | 0.8156 | 1 |
Schistosoma mansoni | zinc finger protein | 0.004 | 0.128 | 0.0891 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0883 | 0.0366 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1446 | 0.1112 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2754 | 1 |
Brugia malayi | PHD-finger family protein | 0.0051 | 0.2119 | 0.2119 |
Echinococcus granulosus | zinc finger protein | 0.004 | 0.128 | 0.0592 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.2754 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.491 | 0.5264 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.2754 | 0.2788 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0883 | 0.0366 |
Echinococcus multilocularis | zinc finger protein | 0.004 | 0.128 | 0.0592 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0042 | 0.1446 | 0.1551 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2754 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0046 | 0.1747 | 0.1287 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.2754 | 0.2788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.