Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.3513 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.3513 | 0.3513 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.3513 | 0.3513 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.3513 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.3513 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.3513 | 0.3513 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.3513 | 0.2518 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.3513 | 0.3513 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.3513 | 0.2518 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.3513 | 0.3513 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.3513 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.3513 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.3513 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.1992 | 0.1992 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.3513 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.3513 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.3513 | 0.3513 |
Leishmania major | pyruvate kinase | 0.0033 | 0.3513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3513 | 0.2518 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.3513 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.3513 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.3513 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.1329 | 0.5 |
Leishmania major | pyruvate kinase | 0.0033 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.3513 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.3513 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.3513 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.3513 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.3513 | 0.2518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.