Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0034 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.3513 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3513 | 0.2518 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.3513 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0024 | 0.1329 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.3513 | 0.2518 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.3513 | 1 |
Leishmania major | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.3513 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.3513 | 0.2518 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.3513 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.3513 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.3513 | 0.5 |
Leishmania major | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.1992 | 0.1992 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.3513 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.3513 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.3513 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.3513 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.3513 | 0.2518 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.3513 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.