Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0.2706 | 0.1581 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0109 | 0.1473 | 0.0159 |
Brugia malayi | RE15519p | 0.0067 | 0.0361 | 0.2375 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0104 | 0.1336 | 1 |
Brugia malayi | AKH receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | neuropeptide F receptor | 0.0067 | 0.0361 | 0.2375 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0086 | 0.0866 | 0.3201 |
Brugia malayi | G-protein coupled receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | follicle stimulating hormone receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0067 | 0.0361 | 0.2375 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0208 | 0.4044 | 1 |
Brugia malayi | thymidylate synthase | 0.0111 | 0.1522 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Dopamine receptor protein 1 | 0.0067 | 0.0361 | 0.2375 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0.1522 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0104 | 0.1336 | 0.8396 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0435 | 1 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | sulfakinin receptor protein | 0.0067 | 0.0361 | 0.2375 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2706 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0086 | 0.0866 | 0.3201 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0215 | 0.4245 | 0.1865 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | larval opioid receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0104 | 0.1336 | 0.8396 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0215 | 0.4245 | 0.3358 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0067 | 0.0361 | 0.2375 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0104 | 0.1336 | 0.8396 |
Schistosoma mansoni | DNA topoisomerase II | 0.0104 | 0.1336 | 0.8396 |
Brugia malayi | Serotonin receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | G protein-coupled receptor | 0.0067 | 0.0361 | 0.2375 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0154 | 0.2655 | 0.9813 |
Brugia malayi | Probable DNA topoisomerase II | 0.0104 | 0.1336 | 0.8777 |
Brugia malayi | Melatonin receptor type 1A | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Dopamine receptor | 0.0067 | 0.0361 | 0.2375 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0215 | 0.4245 | 0.3212 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0435 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2706 | 1 |
Brugia malayi | putative neuropeptide receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Serotonin receptor | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | neuropeptide F receptor | 0.0067 | 0.0361 | 0.2375 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0.1522 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0154 | 0.2655 | 0.9725 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0104 | 0.1336 | 0.8777 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0435 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0154 | 0.2655 | 0.9725 |
Onchocerca volvulus | 0.0111 | 0.1522 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0.1522 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0067 | 0.0361 | 0.2375 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0435 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2706 | 0.1581 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0111 | 0.1522 | 0.1522 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0.1522 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0104 | 0.1336 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0215 | 0.4245 | 0.4245 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0104 | 0.1336 | 0.8396 |
Brugia malayi | GnHR receptor homolog | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Brugia malayi | Dopamine receptor protein 2 | 0.0067 | 0.0361 | 0.2375 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2706 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0067 | 0.0361 | 0.2375 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0154 | 0.2655 | 0.9813 |
Brugia malayi | ORL1-like opioid receptor | 0.0067 | 0.0361 | 0.2375 |
Giardia lamblia | DNA topoisomerase II | 0.0096 | 0.113 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0104 | 0.1336 | 0.8777 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0361 | 0.2375 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2706 | 0.1581 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0215 | 0.4245 | 0.3358 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0104 | 0.1336 | 0.8396 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0104 | 0.1336 | 0.8396 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0067 | 0.0361 | 0.2375 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0435 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0435 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0435 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.