Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.2792 | 0.2792 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0551 | 0.1697 | 0.1697 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0746 | 0.3016 | 0.3016 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0551 | 0.1697 | 0.1697 |
Brugia malayi | hypothetical protein | 0.0449 | 0.1009 | 0.1009 |
Schistosoma mansoni | serine/threonine kinase | 0.0551 | 0.1697 | 0.1697 |
Schistosoma mansoni | phosphorylase B kinase alpha kpb1 | 0.1062 | 0.516 | 0.516 |
Schistosoma mansoni | protein kinase C mu | 0.0436 | 0.0923 | 0.0923 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0551 | 0.1697 | 0.1697 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.053 | 0.1556 | 0.8669 |
Echinococcus granulosus | myotubularin protein 13 | 0.0451 | 0.1021 | 0.1021 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Schistosoma mansoni | phosphorylase B kinase beta kpbb | 0.0712 | 0.2792 | 0.2792 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1778 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.04 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0551 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0886 | 0.0886 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0436 | 0.0923 | 0.2735 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.1366 | 0.1366 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.04 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0565 | 0.1795 | 0.1795 |
Brugia malayi | Protein kinase domain containing protein | 0.0551 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.1062 | 0.516 | 0.516 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0436 | 0.0923 | 0.0923 |
Schistosoma mansoni | vav2 | 0.0451 | 0.1021 | 0.1021 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0436 | 0.0923 | 0.2735 |
Brugia malayi | Variant SH3 domain containing protein | 0.0436 | 0.0923 | 0.0923 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0888 | 0.398 | 0.398 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.03 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0926 | 0.4239 | 0.4239 |
Loa Loa (eye worm) | raf kinase | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0697 | 0.2685 | 0.2685 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0436 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | CAMK/PHK protein kinase | 0.0634 | 0.2261 | 0.2261 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0.1009 | 0.5622 |
Mycobacterium tuberculosis | Conserved protein | 0.0449 | 0.1009 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0551 | 0.1697 | 0.9452 |
Leishmania major | protein kinase A catalytic subunit | 0.03 | 0 | 0.5 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0436 | 0.0923 | 0.0923 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0.1009 | 0.5622 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0461 | 0.109 | 0.109 |
Echinococcus granulosus | protein kinase C gamma type | 0.1313 | 0.6856 | 0.6856 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.03 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0457 | 0.1064 | 0.1064 |
Echinococcus multilocularis | phosphorylase b kinase regulatory | 0.1062 | 0.516 | 0.516 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.03 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0551 | 0.1697 | 0.1697 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0697 | 0.2685 | 0.2685 |
Schistosoma mansoni | protein kinase C mu | 0.0888 | 0.398 | 0.398 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0634 | 0.2261 | 0.2261 |
Brugia malayi | RhoGEF domain containing protein | 0.0436 | 0.0923 | 0.0923 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0634 | 0.2261 | 0.353 |
Echinococcus granulosus | phosphorylase b kinase regulatory | 0.0712 | 0.2792 | 0.2792 |
Brugia malayi | Protein kinase domain containing protein | 0.0551 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0551 | 0.1697 | 0.1697 |
Toxoplasma gondii | AGC kinase | 0.0551 | 0.1697 | 1 |
Schistosoma mansoni | protein kinase C | 0.0502 | 0.1366 | 0.1366 |
Brugia malayi | diacylglycerol kinase | 0.0436 | 0.0923 | 0.0923 |
Brugia malayi | protein kinase C3,putative | 0.0894 | 0.4021 | 0.4021 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Onchocerca volvulus | 0.0502 | 0.1366 | 0.1534 | |
Schistosoma mansoni | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Brugia malayi | Protein kinase domain containing protein | 0.0634 | 0.2261 | 0.2261 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0436 | 0.0923 | 0.0923 |
Echinococcus granulosus | myosin light chain kinase smooth muscle | 0.0461 | 0.109 | 0.109 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0436 | 0.0923 | 0.0923 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1749 | 0.981 | 0.981 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.1021 | 0.1021 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.04 | 0.0679 | 0.0679 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0436 | 0.0923 | 0.0923 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.03 | 0 | 0.5 |
Brugia malayi | diacylglycerol kinase | 0.0436 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.3938 | 0.3938 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.04 | 0.0679 | 0.0679 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0551 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0551 | 0.1697 | 0.1697 |
Echinococcus granulosus | unc 13 munc13 | 0.0502 | 0.1366 | 0.1366 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0551 | 0.1697 | 0.1697 |
Schistosoma mansoni | unc-13 (munc13) | 0.0502 | 0.1366 | 0.1366 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0551 | 0.1697 | 0.1697 |
Schistosoma mansoni | rac gtpase activating protein | 0.0436 | 0.0923 | 0.0923 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0551 | 0.1697 | 0.1697 |
Brugia malayi | RhoGAP domain containing protein | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0551 | 0.1697 | 0.1697 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | N chimaerin | 0.0436 | 0.0923 | 0.0923 |
Brugia malayi | C1-like domain containing protein | 0.0888 | 0.398 | 0.398 |
Brugia malayi | phosphorylase B kinase beta regulatory chain | 0.0712 | 0.2792 | 0.2792 |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0449 | 0.1009 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1778 | 1 | 1 |
Brugia malayi | Pleckstrin Homology Domain | 0.0451 | 0.1021 | 0.1021 |
Trichomonas vaginalis | AGC family protein kinase | 0.0551 | 0.1697 | 0.9452 |
Brugia malayi | Protein kinase domain containing protein | 0.04 | 0.0679 | 0.0679 |
Brugia malayi | Hr1 repeat family protein | 0.0551 | 0.1697 | 0.1697 |
Brugia malayi | Protein kinase c protein 2 | 0.122 | 0.6223 | 0.6223 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0436 | 0.0923 | 0.0923 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1133 | 0.5639 | 0.5639 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.212 | 0.212 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0888 | 0.398 | 0.398 |
Trichomonas vaginalis | AGC family protein kinase | 0.0551 | 0.1697 | 0.9452 |
Loa Loa (eye worm) | hypothetical protein | 0.0977 | 0.4581 | 0.4581 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0551 | 0.1697 | 0.1697 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1778 | 1 | 1 |
Brugia malayi | RhoGAP domain containing protein | 0.0436 | 0.0923 | 0.0923 |
Schistosoma mansoni | atypical protein kinase C | 0.1456 | 0.7825 | 0.7825 |
Echinococcus multilocularis | myosin light chain kinase, smooth muscle | 0.0461 | 0.109 | 0.109 |
Brugia malayi | Protein kinase domain containing protein | 0.0457 | 0.1064 | 0.1064 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1313 | 0.6856 | 0.6856 |
Echinococcus multilocularis | protein kinase c iota type | 0.1424 | 0.7608 | 0.7608 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1276 | 0.6603 | 0.6603 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0436 | 0.0923 | 0.0923 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0452 | 0.1026 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.0697 | 0.2685 | 0.2685 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | phosphorylase kinase gamma subunit | 0.0634 | 0.2261 | 0.2261 |
Onchocerca volvulus | 0.0882 | 0.3938 | 0.7273 | |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0783 | 0.3269 | 0.3269 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0697 | 0.2685 | 0.2685 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0457 | 0.1064 | 0.1064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1749 | 0.981 | 0.981 |
Onchocerca volvulus | Phosphorylase b kinase regulatory subunit beta homolog | 0.0712 | 0.2792 | 0.4715 |
Giardia lamblia | Kinase, AGC PKA | 0.03 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0436 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.1413 | 0.7535 | 0.7535 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0551 | 0.1697 | 0.1697 |
Entamoeba histolytica | hypothetical protein | 0.0436 | 0.0923 | 0.2735 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0436 | 0.0923 | 0.0923 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.076 | 0.3115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.1009 | 0.1009 |
Entamoeba histolytica | protein kinase, putative | 0.0551 | 0.1697 | 0.5299 |
Loa Loa (eye worm) | hypothetical protein | 0.0977 | 0.4581 | 0.4581 |
Loa Loa (eye worm) | hypothetical protein | 0.0867 | 0.3839 | 0.3839 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0436 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.0923 | 0.0923 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.03 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0886 | 0.0886 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0551 | 0.1697 | 0.1697 |
Echinococcus multilocularis | phosphorylase b kinase regulatory | 0.0712 | 0.2792 | 0.2792 |
Brugia malayi | Protein kinase domain containing protein | 0.0565 | 0.1795 | 0.1795 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0461 | 0.109 | 0.109 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0551 | 0.1697 | 0.1697 |
Echinococcus granulosus | phosphorylase kinase gamma subunit | 0.0634 | 0.2261 | 0.2261 |
Echinococcus granulosus | phosphorylase b kinase regulatory | 0.1062 | 0.516 | 0.516 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0436 | 0.0923 | 0.0923 |
Onchocerca volvulus | 0.0977 | 0.4581 | 0.8708 | |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0436 | 0.0923 | 0.0923 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.04 | 0.0679 | 0.0679 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.1424 | 0.7608 | 0.7608 |
Echinococcus granulosus | NDR protein kinase | 0.0551 | 0.1697 | 0.1697 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0565 | 0.1795 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0551 | 0.1697 | 0.1697 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0551 | 0.1697 | 0.1697 |
Echinococcus granulosus | N chimaerin | 0.0436 | 0.0923 | 0.0923 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0551 | 0.1697 | 0.1697 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.03 | 0 | 0.5 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.03 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1528 | 0.8308 | 0.8308 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1749 | 0.981 | 0.981 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1749 | 0.981 | 0.981 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1778 | 1 | 1 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.03 | 0 | 0.5 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0502 | 0.1366 | 0.1366 |
Onchocerca volvulus | Putative phosphorylase b kinase regulatory subunit alpha | 0.1062 | 0.516 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0449 | 0.1009 | 0.5622 |
Onchocerca volvulus | 0.0431 | 0.0886 | 0.0461 | |
Echinococcus multilocularis | myotubularin protein 13 | 0.0451 | 0.1021 | 0.1021 |
Entamoeba histolytica | protein kinase, putative | 0.0565 | 0.1795 | 0.5625 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0502 | 0.1366 | 0.1366 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0551 | 0.1697 | 0.1697 |
Echinococcus multilocularis | protein kinase c eta type | 0.0436 | 0.0923 | 0.0923 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0502 | 0.1366 | 0.1366 |
Entamoeba histolytica | protein kinase, putative | 0.0551 | 0.1697 | 0.5299 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.04 | 0.0679 | 0.0679 |
Brugia malayi | phosphorylase B kinase alpha regulatory chain | 0.1062 | 0.516 | 0.516 |
Loa Loa (eye worm) | myosin heavy chain | 0.0449 | 0.1009 | 0.1009 |
Echinococcus granulosus | protein kinase c eta type | 0.0436 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0977 | 0.4581 | 0.4581 |
Entamoeba histolytica | protein kinase, putative | 0.0565 | 0.1795 | 0.5625 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0436 | 0.0923 | 0.0923 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0457 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0867 | 0.3839 | 0.7053 | |
Brugia malayi | hypothetical protein | 0.1062 | 0.516 | 0.516 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0457 | 0.1064 | 0.1064 |
Schistosoma mansoni | unc-13 (munc13) | 0.0502 | 0.1366 | 0.1366 |
Trichomonas vaginalis | AGC family protein kinase | 0.0565 | 0.1795 | 1 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0436 | 0.0923 | 0.0923 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0436 | 0.0923 | 0.5441 |
Loa Loa (eye worm) | hypothetical protein | 0.1062 | 0.516 | 0.516 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IA (functional) | 0 | Tested for cytotoxicity of compound against MCF-7 (breast) cell line; IA means inactive. | ChEMBL. | 12502372 |
IA (functional) | 0 | Tested for cytotoxicity of compound against NCI-H460 (lung)cell line; IA means inactive. | ChEMBL. | 12502372 |
IA (functional) | 0 | Tested for cytotoxicity of compound against SF-268(CNS) cell line; IA means inactive. | ChEMBL. | 12502372 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.