Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0217 | 0.4212 | 0.4357 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0304 | 0.0389 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0112 | 0.1817 | 0.4053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0195 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0201 | 0.0258 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0105 | 0.1654 | 0.904 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0195 | 0.0869 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0479 | 0.2646 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0217 | 0.4212 | 0.4358 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0112 | 0.0144 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0217 | 0.4212 | 0.4425 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0087 | 0.1241 | 0.1375 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0439 | 0.9273 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0105 | 0.1654 | 0.1569 |
Giardia lamblia | DNA topoisomerase II | 0.0097 | 0.1472 | 0.5 |
Loa Loa (eye worm) | ICD-1 protein | 0.0041 | 0.0195 | 0.025 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0046 | 0.0305 | 0.1134 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0105 | 0.1654 | 0.1607 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0439 | 0.9273 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0386 | 0.1609 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.2858 | 0.3503 |
Leishmania major | DNA topoisomerase ii | 0.0087 | 0.1241 | 0.1375 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0158 | 0.2858 | 0.2934 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0156 | 0.2814 | 0.3444 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.7799 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0166 | 0.3052 | 0.3064 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0439 | 0.9273 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0386 | 0.0495 |
Schistosoma mansoni | transcription factor btf3 | 0.0041 | 0.0195 | 0.0552 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0386 | 0.1609 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0087 | 0.1241 | 0.1375 |
Loa Loa (eye worm) | thymidylate synthase | 0.0112 | 0.1817 | 0.233 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0487 | 0.0391 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0386 | 0.0289 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0386 | 0.1609 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.7799 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0439 | 0.9273 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0051 | 0.0424 | 0.0319 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.011 | 0.1774 | 0.174 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.2858 | 0.3503 |
Echinococcus granulosus | dihydrofolate reductase | 0.0046 | 0.0305 | 0.1134 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0217 | 0.4212 | 0.4425 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.7799 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0046 | 0.0305 | 0.0207 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0487 | 0.0625 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0046 | 0.0305 | 0.0391 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0087 | 0.1241 | 0.1375 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0105 | 0.1654 | 0.1569 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0156 | 0.2814 | 0.3444 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0105 | 0.1654 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0439 | 0.9273 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0217 | 0.4212 | 0.4357 |
Brugia malayi | thymidylate synthase | 0.0112 | 0.1817 | 0.1734 |
Echinococcus granulosus | thymidylate synthase | 0.0112 | 0.1817 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.7799 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0105 | 0.1654 | 0.904 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.2858 | 0.2934 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.2858 | 0.2934 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0304 | 0.0389 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0487 | 0.0391 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0386 | 0.1666 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0479 | 0.0382 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0156 | 0.2814 | 0.3444 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.019 | 0.0522 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0439 | 0.9273 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0105 | 0.1654 | 0.1607 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0112 | 0.1817 | 1 |
Echinococcus granulosus | transcription factor btf3 | 0.0041 | 0.0195 | 0.0487 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0374 | 0.7799 | 0.7776 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0105 | 0.1654 | 0.212 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0439 | 0.9273 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0386 | 0.1666 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0053 | 0.0479 | 0.0373 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0105 | 0.1654 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.019 | 0.0522 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0195 | 0.0869 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0386 | 0.1609 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0046 | 0.0305 | 0.0002 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0105 | 0.1654 | 0.1607 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.2858 | 0.3503 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0053 | 0.0479 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.01 | 0.0129 |
Brugia malayi | beta-NAC-like protein | 0.0041 | 0.0195 | 0.0096 |
Brugia malayi | Dihydrofolate reductase | 0.0046 | 0.0305 | 0.0207 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0439 | 0.9273 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0112 | 0.1817 | 0.1686 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0087 | 0.1241 | 0.1375 |
Brugia malayi | Probable DNA topoisomerase II | 0.0105 | 0.1654 | 0.1569 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0209 | 0.4035 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0046 | 0.0305 | 0.1194 |
Echinococcus multilocularis | thymidylate synthase | 0.0112 | 0.1817 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0105 | 0.1654 | 0.9047 |
Onchocerca volvulus | 0.0112 | 0.1817 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0201 | 0.0258 |
Echinococcus multilocularis | transcription factor btf3 | 0.0041 | 0.0195 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0487 | 0.0625 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0156 | 0.2814 | 0.3444 |
Mycobacterium ulcerans | thymidylate synthase | 0.0112 | 0.1817 | 0.1686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0386 | 0.1666 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0112 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.3626 | 0.465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.