Detailed information for compound 779728

Basic information

Technical information
  • TDR Targets ID: 779728
  • Name: N-[(4-ethylphenyl)methyl]-5-(3-methoxyphenyl) -1-methylimidazol-2-amine
  • MW: 321.416 | Formula: C20H23N3O
  • H donors: 1 H acceptors: 1 LogP: 4.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)CNc1ncc(n1C)c1cccc(c1)OC
  • InChi: 1S/C20H23N3O/c1-4-15-8-10-16(11-9-15)13-21-20-22-14-19(23(20)2)17-6-5-7-18(12-17)24-3/h5-12,14H,4,13H2,1-3H3,(H,21,22)
  • InChiKey: LJLFVKAMTHSBKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-ethylphenyl)methyl]-5-(3-methoxyphenyl)-1-methyl-imidazol-2-amine
  • N-[(4-ethylphenyl)methyl]-5-(3-methoxyphenyl)-1-methyl-2-imidazolamine
  • (4-ethylbenzyl)-[5-(3-methoxyphenyl)-1-methyl-imidazol-2-yl]amine
  • STK121956
  • ZINC04678480
  • NCGC00102371-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.4607 0.642
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0484 0.0609
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0108 0.018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0049 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0789 0.1145
Onchocerca volvulus 0.0286 0.6886 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0699 0.1016
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0484 0.0436
Entamoeba histolytica Ran family GTPase 0.0021 0.0108 0.1116
Giardia lamblia GTOR 0.0054 0.097 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0049 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.097 0.1409
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0071 0.0119
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0049 0.051
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2528 0.2491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0404 0.0587
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0108 0.0059
Brugia malayi jmjC domain containing protein 0.0115 0.2528 0.4214
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0688 0.709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0413 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0789 0.1145
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0108 0.1116
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1732 0.2516
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.4607 0.458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0484 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0404 0.0587
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0108 0.0059
Schistosoma mansoni ran 0.0021 0.0108 0.0082
Echinococcus granulosus chromobox protein 1 0.0084 0.1732 0.1691
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0699 0.1166
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0699 0.0653
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0673 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0333 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.097 0.1409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0514 0.0747
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.097 0.1617
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0699 0.0975
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0699 0.1016
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1732 0.2414
Plasmodium vivax SET domain protein, putative 0.0036 0.0505 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0505 0.0458
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0484 0.635
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.3777 0.3746
Brugia malayi Heterochromatin protein 1 0.0084 0.1732 0.2887
Echinococcus multilocularis snurportin 1 0.0297 0.7175 0.7161
Echinococcus multilocularis chromobox protein 1 0.0084 0.1732 0.1691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0413 0.0599
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4607 0.458
Schistosoma mansoni ran 0.0021 0.0108 0.0082
Onchocerca volvulus 0.0037 0.0529 0.0768
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1122 0.1869
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0049 0.051
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0673 0.0626
Echinococcus granulosus GPCR family 2 0.0019 0.0071 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0699 0.1016
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0049 0.051
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0699 0.7208
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0673 0.0937
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.097 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0857 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0437 0.0635
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0296 0.3176
Brugia malayi Importin beta-1 subunit 0.0028 0.0296 0.0493
Onchocerca volvulus 0.005 0.0857 0.1244
Echinococcus granulosus importin subunit beta 1 0.0028 0.0296 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0505 0.0639
Echinococcus granulosus snurportin 1 0.0297 0.7175 0.7161
Trichomonas vaginalis ran, putative 0.0021 0.0108 0.0157
Loa Loa (eye worm) hypothetical protein 0.006 0.1122 0.1563
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0296 0.3051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0333 0.0483
Schistosoma mansoni alpha-glucosidase 0.0169 0.3907 0.5414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0332 0.0482
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0296 0.3051
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0635 0.1059
Echinococcus multilocularis chromobox protein 1 0.0084 0.1732 0.1691
Loa Loa (eye worm) hypothetical protein 0.0028 0.0296 0.0412
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0836 0.079
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0049 0.051
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0699 0.1016
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0673 0.0626
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.024 0.2474
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1923 0.2629
Leishmania major importin beta-1 subunit, putative 0.0023 0.0162 0.1665
Brugia malayi Pre-SET motif family protein 0.0036 0.0505 0.0842
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0505 0.6714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0505 0.0639
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0099
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.097 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.097 0.1409
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0789 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0687 0.0997
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0108 0.0151
Schistosoma mansoni hypothetical protein 0.0041 0.0635 0.0822
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0296 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0484 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0049 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0688 0.709
Schistosoma mansoni chromobox protein 0.0084 0.1732 0.2362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0413 0.0599
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0505 0.0639
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.144 0.2007
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0162 0.0235
Leishmania major GTP-binding protein, putative 0.0021 0.0108 0.1116
Schistosoma mansoni hypothetical protein 0.0152 0.3465 0.4794
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0071 0.0119
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0615 0.8577
Schistosoma mansoni thyroid hormone receptor 0.0164 0.3777 0.5231
Echinococcus granulosus chromobox protein 1 0.0084 0.1732 0.1691
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.097 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0673 0.0875
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.0235
Loa Loa (eye worm) hypothetical protein 0.0036 0.0505 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Echinococcus granulosus peregrin 0.0035 0.0484 0.0436
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0688 0.709
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.097 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0049 0.0072
Schistosoma mansoni hypothetical protein 0.0297 0.7175 1
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0071 0.0022
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.097 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0699 0.0653
Brugia malayi PHD-finger family protein 0.0035 0.0484 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0332 0.0482
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.097 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.3465 0.3433
Trichomonas vaginalis set domain proteins, putative 0.0286 0.6886 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0071 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0164 0.3777 0.5231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0333 0.0483
Schistosoma mansoni alpha glucosidase 0.0044 0.0699 0.0912
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0699 0.1016
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1122 0.1869
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0484 0.635
Trichomonas vaginalis chromobox protein, putative 0.0051 0.088 0.1278
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.0235
Onchocerca volvulus Alhambra homolog 0.0035 0.0484 0.0702
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0071 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0687 0.0997
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0162 0.1665
Schistosoma mansoni alpha-glucosidase 0.0169 0.3907 0.5414
Plasmodium falciparum phd finger protein, putative 0.0035 0.0484 1
Schistosoma mansoni hypothetical protein 0.0035 0.0484 0.0609
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0049 0.051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.097 1
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Loa Loa (eye worm) hypothetical protein 0.006 0.1109 0.1546
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0071 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0332 0.0482
Onchocerca volvulus 0.0114 0.2489 0.3615
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2528 0.2491
Brugia malayi RNA, U transporter 1 0.0079 0.1607 0.2678
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.097 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0836 0.079
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.003
Entamoeba histolytica hypothetical protein 0.0023 0.0162 0.1665
Loa Loa (eye worm) hypothetical protein 0.0047 0.0789 0.1099
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.6 0.8362
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.3465 0.3433
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0699 0.1016
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0687 0.0997
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.4607 0.7678
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0071 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0505 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0437 0.0635
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4607 0.458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0049 0.0072
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1109 0.1487
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.7175 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0699 0.1016
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0699 0.7208
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0699 0.7208
Brugia malayi chromobox protein homolog 3 0.0047 0.0789 0.1315
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0049 0.0069
Trichomonas vaginalis chromobox protein, putative 0.0051 0.088 0.1278
Loa Loa (eye worm) hypothetical protein 0.006 0.1126 0.1569
Trypanosoma brucei glucosidase, putative 0.0044 0.0699 0.7208
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1122 0.1563
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.088 0.1278
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.016 0.1652
Giardia lamblia PHD finger protein 15 0.0035 0.0484 0.4355
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0108 0.1116
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0699 1
Brugia malayi Pre-SET motif family protein 0.0251 0.6 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0484 0.0436
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0484 0.9458
Loa Loa (eye worm) hypothetical protein 0.0037 0.0529 0.0737
Schistosoma mansoni chromobox protein 0.0084 0.1732 0.2362
Echinococcus multilocularis GPCR, family 2 0.0019 0.0071 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.097 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0333 0.0483
Loa Loa (eye worm) hypothetical protein 0.0041 0.0635 0.0885
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.097 0.0925
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0699 0.1016
Plasmodium falciparum importin beta, putative 0.0028 0.0296 0.5002
Schistosoma mansoni importin beta-1 0.0028 0.0296 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0615 0.0893
Schistosoma mansoni hypothetical protein 0.0019 0.0071 0.003
Brugia malayi jmjC domain containing protein 0.0043 0.0673 0.1121
Echinococcus multilocularis peregrin 0.0035 0.0484 0.0436
Brugia malayi Bromodomain containing protein 0.0035 0.0484 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0768 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0049 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0687 0.0997
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0484 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0687 0.0997
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0699 0.7208
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0108 0.1116
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.097 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.097 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0296 0.4731
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0471 0.0424
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0505 0.0458
Onchocerca volvulus 0.006 0.1109 0.1611
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0699 0.1016
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0699 0.7208
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1732 0.2516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0049 0.0072

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.0918 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 23.2809 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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