Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0278 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0111 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2707 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0278 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2707 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0 | 0.5 |
Onchocerca volvulus | 0.0111 | 0 | 0.5 | |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0278 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0278 | 1 | 0.5 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0278 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0278 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2707 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0 | 0.5 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0278 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0111 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.