Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2149 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3345 | 0.3895 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2241 | 0.2241 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3345 | 0.3895 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3345 | 0.3895 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2241 | 0.2241 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3345 | 0.3345 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2149 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3345 | 0.3895 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3345 | 0.3345 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8588 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3345 | 0.3895 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3345 | 0.3345 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8588 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2241 | 0.261 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2149 | 0.2149 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8588 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2241 | 0.2241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3345 | 0.3345 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2149 | 0.2149 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2241 | 0.2241 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2149 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2149 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2241 | 0.2241 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2149 | 0.2149 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2241 | 0.2241 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3345 | 0.3345 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2241 | 0.2241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3345 | 0.3345 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3345 | 0.3345 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2149 | 0.2149 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3345 | 0.3895 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2241 | 0.261 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2149 | 0.2503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.