Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 1 | 0.5 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0039 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 1 | 0.5 |
Toxoplasma gondii | NAC domain-containing protein | 0.0039 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 0.5 |
Echinococcus granulosus | transcription factor btf3 | 0.0039 | 1 | 1 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0039 | 1 | 0.5 |
Echinococcus multilocularis | transcription factor btf3 | 0.0039 | 1 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0039 | 1 | 0.5 |
Leishmania major | basic transcription factor 3a, putative | 0.0039 | 1 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 1 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0039 | 1 | 0.5 |
Schistosoma mansoni | transcription factor btf3 | 0.0039 | 1 | 1 |
Loa Loa (eye worm) | ICD-1 protein | 0.0039 | 1 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0039 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.