Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0047 | 0.2644 | 0.405 |
Brugia malayi | jmjC domain containing protein | 0.0026 | 0.0699 | 0.1071 |
Echinococcus multilocularis | jumonji domain containing protein | 0.003 | 0.1065 | 0.0814 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.4872 | 0.4728 |
Giardia lamblia | PHD finger protein 15 | 0.0022 | 0.0274 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0022 | 0.0274 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0047 | 0.2644 | 0.2437 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0047 | 0.2644 | 0.2437 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0026 | 0.0699 | 0.0437 |
Leishmania major | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0022 | 0.0274 | 0.0419 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0088 | 0.6529 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0274 | 0.0419 |
Schistosoma mansoni | jumonji domain containing protein | 0.0056 | 0.3512 | 0.3329 |
Brugia malayi | MH2 domain containing protein | 0.0088 | 0.6529 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0022 | 0.0274 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0037 | 0.1709 | 0.2617 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0047 | 0.2644 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0047 | 0.2644 | 0.2437 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1718 | 0.2631 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0022 | 0.0274 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0037 | 0.1709 | 0.2617 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.4872 | 0.4728 |
Brugia malayi | TAR-binding protein | 0.0047 | 0.2644 | 0.405 |
Echinococcus multilocularis | geminin | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0615 | 0.0942 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.4872 | 0.7462 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0026 | 0.0699 | 0.0437 |
Schistosoma mansoni | tar DNA-binding protein | 0.0047 | 0.2644 | 0.2437 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0019 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0022 | 0.0274 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0615 | 0.0351 |
Brugia malayi | RNA binding protein | 0.0047 | 0.2644 | 0.405 |
Brugia malayi | Bromodomain containing protein | 0.0022 | 0.0274 | 0.0419 |
Schistosoma mansoni | tar DNA-binding protein | 0.0047 | 0.2644 | 0.2437 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0026 | 0.0699 | 0.0437 |
Echinococcus multilocularis | tar DNA binding protein | 0.0047 | 0.2644 | 0.2437 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0022 | 0.0274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1709 | 0.2617 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0025 | 0.0615 | 0.0942 |
Echinococcus granulosus | jumonji domain containing protein | 0.003 | 0.1065 | 0.0814 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0047 | 0.2644 | 0.405 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0274 | 0.0419 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0026 | 0.0699 | 0.1071 |
Loa Loa (eye worm) | RNA binding protein | 0.0047 | 0.2644 | 0.405 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0026 | 0.0699 | 0.0437 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0088 | 0.6529 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0047 | 0.2644 | 0.2437 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0045 | 0.2426 | 0.3715 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0037 | 0.1709 | 0.2617 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.