Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0745 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.251 | 0.638 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0745 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0479 | 0.0479 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1292 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0436 | 0.5844 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1292 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0436 | 0.5844 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0745 | 0.0745 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0479 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.251 | 0.638 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0745 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1292 | 0.3283 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0745 | 0.0745 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0745 | 0.0745 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0745 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.251 | 0.251 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1292 | 0.3283 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.251 | 0.638 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0745 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0479 | 0.0479 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.3934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0745 | 0.0745 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0745 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0745 | 1 |
Onchocerca volvulus | 0.0024 | 0.0745 | 1 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0745 | 0.5772 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0479 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0745 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3934 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.251 | 0.638 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0479 | 0.0479 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1292 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.251 | 0.638 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.251 | 0.251 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.3934 | 0.3934 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1292 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.3934 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0745 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0745 | 0.5772 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0479 | 0.6421 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0745 | 0.0745 |
Brugia malayi | RNA binding protein | 0.0063 | 0.251 | 0.251 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.251 | 0.638 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0479 | 0.0479 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.0479 | 0.6421 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.251 | 0.251 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0436 | 0.5844 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.023 | 1 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0745 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0745 | 0.5772 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.251 | 0.251 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0745 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0436 | 0.5844 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1292 | 0.3283 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1292 | 0.3283 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0745 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.251 | 0.251 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.3934 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3934 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.3934 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.3934 | 0.3934 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3934 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0745 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1292 | 0.1292 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0745 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0745 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.251 | 0.638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.