Detailed information for compound 780452

Basic information

Technical information
  • TDR Targets ID: 780452
  • Name: 4-(furan-2-carbonylamino)benzoic acid
  • MW: 231.204 | Formula: C12H9NO4
  • H donors: 2 H acceptors: 3 LogP: 1.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccco1)Nc1ccc(cc1)C(=O)O
  • InChi: 1S/C12H9NO4/c14-11(10-2-1-7-17-10)13-9-5-3-8(4-6-9)12(15)16/h1-7H,(H,13,14)(H,15,16)
  • InChiKey: LKSXLVUUFLNDSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(2-furyl-oxomethyl)amino]benzoic acid
  • 4-(furan-2-ylcarbonylamino)benzoic acid
  • 5768-34-3
  • 4-[(Furan-2-carbonyl)-amino]-benzoic acid
  • BAS 00558206
  • Oprea1_221658
  • 4-(2-Furamido)benzoic acid
  • 4-(2-Furoylamino)benzoic acid
  • NSC270093
  • STK324568
  • CBDivE_004656
  • Oprea1_024007

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2828 0.2828
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1698 0.6003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2828 0.2828
Echinococcus granulosus tar DNA binding protein 0.0062 0.2828 0.2828
Echinococcus multilocularis geminin 0.0171 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Schistosoma mansoni hypothetical protein 0.0171 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1698 0.1698
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0 0.5
Brugia malayi RNA binding protein 0.0062 0.2828 1
Brugia malayi TAR-binding protein 0.0062 0.2828 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2828 0.2828
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2828 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1698 0.1698
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1698 0.6003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1698 0.1698
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2828 0.2828
Leishmania major DNA polymerase eta, putative 0.0019 0 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0019 0 0.5
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2828 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2828 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1698 0.1698
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0062 0.2828 1
Leishmania major DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1698 0.1698
Trypanosoma brucei unspecified product 0.0019 0 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0 0.5
Schistosoma mansoni hypothetical protein 0.0171 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1698 0.1698
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2828 0.2828
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0 0.5
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2828 0.2828
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1698 0.1698

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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