Detailed information for compound 78048

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.48 | Formula: C20H26NNaO4S
  • H donors: 1 H acceptors: 4 LogP: 4.27 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)CCC/C=C\C[C@H]1[C@@H]2CCC([C@@H]1NS(=O)(=O)c1ccccc1)C2.[Na+]
  • InChi: 1S/C20H27NO4S.Na/c22-19(23)11-7-2-1-6-10-18-15-12-13-16(14-15)20(18)21-26(24,25)17-8-4-3-5-9-17;/h1,3-6,8-9,15-16,18,20-21H,2,7,10-14H2,(H,22,23);/q;+1/p-1/b6-1-;/t15-,16?,18+,20+;/m1./s1
  • InChiKey: AXQQPGSIAMTSKK-FKSPIUSYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Echinococcus multilocularis Diacylglycerol kinase theta 0.0132 0.1123 0.1737
Brugia malayi C1-like domain containing protein 0.0263 0.2551 0.3947
Echinococcus multilocularis serine:threonine protein kinase 38 0.0165 0.1483 0.2295
Brugia malayi hypothetical protein 0.0039 0.0108 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1483 0.2295
Schistosoma mansoni atypical protein kinase C 0.0298 0.2928 0.4529
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0132 0.1123 0.1737
Echinococcus granulosus Rac GTPase activating protein 1 0.0132 0.1123 0.1737
Schistosoma mansoni unc-13 (munc13) 0.0148 0.129 0.1996
Onchocerca volvulus 0.0135 0.1148 0.1402
Onchocerca volvulus Dual oxidase homolog 0.0135 0.1148 0.1402
Onchocerca volvulus Peroxidase homolog 0.0135 0.1148 0.1402
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0165 0.1483 0.1483
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1483 0.9624
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0165 0.1483 0.2295
Schistosoma mansoni hypothetical protein 0.0057 0.0295 0.0457
Brugia malayi protein kinase C3,putative 0.0136 0.1167 0.1805
Brugia malayi Animal haem peroxidase family protein 0.0135 0.1148 0.1777
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Echinococcus multilocularis N chimaerin 0.0132 0.1123 0.1737
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0131 0.1107 0.1107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0273 0.0422
Loa Loa (eye worm) RasGEF domain-containing protein 0.0132 0.1123 0.1123
Plasmodium falciparum dihydroorotase, putative 0.0245 0.2352 1
Echinococcus multilocularis peroxidasin 0.0135 0.1148 0.1777
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0263 0.2551 0.2551
Echinococcus multilocularis protein kinase c eta type 0.0132 0.1123 0.1737
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0136 0.1167 0.1167
Onchocerca volvulus Peroxidase homolog 0.0135 0.1148 0.1402
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0108 0.0166
Echinococcus granulosus N chimaerin 0.0132 0.1123 0.1737
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0325 0.3226 0.3226
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0912 0.9639 0.9639
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Echinococcus granulosus thymidylate synthase 0.0117 0.096 0.1486
Loa Loa (eye worm) hypothetical protein 0.0259 0.2507 0.2507
Loa Loa (eye worm) hypothetical protein 0.0438 0.4459 0.4459
Onchocerca volvulus 0.0135 0.1148 0.1402
Loa Loa (eye worm) animal heme peroxidase 0.0135 0.1148 0.1148
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.1123 0.335
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0085 0.0131
Brugia malayi Protein kinase domain containing protein 0.0136 0.1167 0.1805
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1167 0.1805
Echinococcus granulosus peroxidasin 0.0135 0.1148 0.1777
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0132 0.1123 0.1123
Schistosoma mansoni peroxidasin 0.0135 0.1148 0.1777
Echinococcus granulosus Protein kinase C brain isozyme 0.0618 0.6432 0.9949
Brugia malayi thymidylate synthase 0.0117 0.096 0.1486
Trypanosoma brucei rac serine-threonine kinase, putative 0.017 0.153 1
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Loa Loa (eye worm) dihydrofolate reductase 0.0048 0.0201 0.0201
Brugia malayi Animal haem peroxidase family protein 0.0135 0.1148 0.1777
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.1123 0.1123
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0108 0.0166
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0165 0.1483 0.2295
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0165 0.1483 0.2295
Echinococcus granulosus protein kinase c epsilon type 0.0621 0.6464 1
Onchocerca volvulus 0.0127 0.1063 0.1297
Loa Loa (eye worm) hypothetical protein 0.0305 0.3014 0.3014
Echinococcus multilocularis RNA directed DNA polymerase 0.0305 0.3014 0.4663
Loa Loa (eye worm) hypothetical protein 0.0132 0.1123 0.1123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0108 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0618 0.6432 0.9949
Echinococcus multilocularis protein kinase c iota type 0.0298 0.2928 0.4529
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0165 0.1483 0.2295
Loa Loa (eye worm) hypothetical protein 0.0132 0.1123 0.1123
Schistosoma mansoni diacylglycerol kinase theta 0.0132 0.1123 0.1737
Loa Loa (eye worm) hypothetical protein 0.0137 0.1169 0.1169
Schistosoma mansoni protein kinase C mu 0.0132 0.1123 0.1737
Loa Loa (eye worm) hypothetical protein 0.0132 0.1123 0.1123
Loa Loa (eye worm) raf kinase 0.0132 0.1123 0.1123
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0263 0.2554 0.2554
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0161 0.1439 0.9269
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0136 0.1167 0.1805
Schistosoma mansoni unc-13 (munc13) 0.0148 0.129 0.1996
Brugia malayi Ras association domain family 1 isoform A 0.0132 0.1123 0.1737
Brugia malayi Protein kinase domain containing protein 0.0165 0.1483 0.2295
Entamoeba histolytica protein kinase, putative 0.0165 0.1483 0.454
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0165 0.1483 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0165 0.1483 0.1483
Brugia malayi Blistered cuticle protein 3 0.0135 0.1148 0.1777
Loa Loa (eye worm) blistered cuticle protein 3 0.0135 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Echinococcus granulosus protein kinase c iota type 0.0298 0.2928 0.4529
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0117 0.096 0.1486
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1167 0.1805
Echinococcus multilocularis dihydrofolate reductase 0.0048 0.0201 0.0311
Echinococcus multilocularis raf serine:threonine protein kinase 0.0132 0.1123 0.1737
Schistosoma mansoni serine/threonine protein kinase 0.0618 0.6432 0.9949
Schistosoma mansoni protein kinase C mu 0.0263 0.2551 0.3947
Onchocerca volvulus Peroxidasin homolog 0.0135 0.1148 0.1402
Schistosoma mansoni hypothetical protein 0.0185 0.17 0.263
Loa Loa (eye worm) hypothetical protein 0.0127 0.1063 0.1063
Brugia malayi Protein kinase c protein 2 0.0457 0.467 0.7225
Onchocerca volvulus 0.0259 0.2507 0.3059
Onchocerca volvulus 0.078 0.8195 1
Schistosoma mansoni dihydrofolate reductase 0.0048 0.0201 0.0311
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0165 0.1483 0.2295
Loa Loa (eye worm) AGC/AKT protein kinase 0.017 0.153 0.153
Echinococcus granulosus unc 13 munc13 0.0148 0.129 0.1996
Brugia malayi Pleckstrin Homology Domain 0.0137 0.1169 0.1809
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.1123 0.1737
Loa Loa (eye worm) hypothetical protein 0.078 0.8195 0.8195
Loa Loa (eye worm) animal heme peroxidase 0.0135 0.1148 0.1148
Echinococcus granulosus NDR protein kinase 0.0165 0.1483 0.2295
Brugia malayi RhoGAP domain containing protein 0.0132 0.1123 0.1737
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.1123 0.1737
Echinococcus granulosus serine:threonine protein kinase N2 0.0165 0.1483 0.2295
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.1123 0.1737
Echinococcus multilocularis geminin 0.0185 0.17 0.263
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.1123 0.335
Brugia malayi RhoGAP domain containing protein 0.0132 0.1123 0.1737
Loa Loa (eye worm) hypothetical protein 0.0132 0.1123 0.1123
Echinococcus multilocularis serine threonine protein kinase 0.0486 0.4987 0.7715
Brugia malayi Variant SH3 domain containing protein 0.0132 0.1123 0.1737
Echinococcus granulosus protein kinase c eta type 0.0132 0.1123 0.1737
Schistosoma mansoni serine/threonine kinase 0.0165 0.1483 0.2295
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Loa Loa (eye worm) hypothetical protein 0.078 0.8195 0.8195
Brugia malayi protein kinase C II. 0.0621 0.6464 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0273 0.0273
Schistosoma mansoni hypothetical protein 0.0039 0.0108 0.0166
Echinococcus granulosus geminin 0.0185 0.17 0.263
Loa Loa (eye worm) AGC/PKN protein kinase 0.0165 0.1483 0.1483
Brugia malayi Protein kinase domain containing protein 0.0165 0.1483 0.2295
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0165 0.1483 0.2935
Schistosoma mansoni protein kinase C 0.0148 0.129 0.1996
Entamoeba histolytica protein kinase, putative 0.0165 0.1483 0.454
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0185 0.17 0.263
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0148 0.129 0.1996
Echinococcus granulosus Diacylglycerol kinase theta 0.0132 0.1123 0.1737
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0132 0.1123 0.1123
Brugia malayi Animal haem peroxidase family protein 0.0135 0.1148 0.1777
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0263 0.2551 0.3947
Onchocerca volvulus 0.0135 0.1148 0.1402
Schistosoma mansoni peroxidasin 0.0135 0.1148 0.1777
Schistosoma mansoni diacylglycerol kinase theta 0.0132 0.1123 0.1737
Schistosoma mansoni serine/threonine protein kinase 0.0621 0.6464 1
Echinococcus multilocularis unc 13 (munc13) 0.0148 0.129 0.1996
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0117 0.096 1
Schistosoma mansoni hypothetical protein 0.0132 0.1123 0.1737
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0136 0.1167 0.1805
Echinococcus multilocularis Rac GTPase activating protein 1 0.0132 0.1123 0.1737
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0165 0.1483 0.5
Loa Loa (eye worm) AGC/NDR protein kinase 0.0165 0.1483 0.1483
Echinococcus granulosus myotubularin protein 13 0.0137 0.1169 0.1809
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0273 0.0422
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0132 0.1123 0.1123
Echinococcus granulosus dihydrofolate reductase 0.0048 0.0201 0.0311
Loa Loa (eye worm) hypothetical protein 0.0148 0.129 0.129
Toxoplasma gondii AGC kinase 0.0165 0.1483 0.2936
Onchocerca volvulus Peroxidasin homolog 0.0135 0.1148 0.1402
Brugia malayi Animal haem peroxidase family protein 0.0135 0.1148 0.1777
Schistosoma mansoni vav2 0.0137 0.1169 0.1809
Brugia malayi Hr1 repeat family protein 0.0165 0.1483 0.2295
Loa Loa (eye worm) animal heme peroxidase 0.0135 0.1148 0.1148
Brugia malayi diacylglycerol kinase 0.0132 0.1123 0.1737
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Entamoeba histolytica protein kinase, putative 0.017 0.153 0.4694
Loa Loa (eye worm) hypothetical protein 0.0127 0.1063 0.1063
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1483 0.2295
Brugia malayi Animal haem peroxidase family protein 0.0135 0.1148 0.1777
Plasmodium vivax dihydroorotase, putative 0.0245 0.2352 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Brugia malayi Dihydrofolate reductase 0.0048 0.0201 0.0311
Onchocerca volvulus 0.0263 0.2554 0.3116
Onchocerca volvulus 0.0148 0.129 0.1574
Echinococcus multilocularis thymidylate synthase 0.0117 0.096 0.1486
Brugia malayi dihydrofolate reductase family protein 0.0048 0.0201 0.0311
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1483 0.9624
Loa Loa (eye worm) hypothetical protein 0.078 0.8195 0.8195
Schistosoma mansoni rac gtpase activating protein 0.0132 0.1123 0.1737
Brugia malayi hypothetical protein 0.0135 0.1148 0.1777
Onchocerca volvulus 0.0117 0.096 0.1172
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0165 0.1483 0.1483
Brugia malayi Protein kinase domain containing protein 0.017 0.153 0.2367
Echinococcus multilocularis protein kinase c epsilon type 0.0621 0.6464 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0317 0.3138 1
Mycobacterium tuberculosis Hypothetical protein 0.0056 0.0288 0.1148
Brugia malayi diacylglycerol kinase 0.0132 0.1123 0.1737
Echinococcus multilocularis serine:threonine protein kinase N2 0.0474 0.4852 0.7506
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1483 0.2295
Echinococcus multilocularis serine:threonine protein kinase N2 0.0165 0.1483 0.2295
Mycobacterium ulcerans thymidylate synthase 0.0117 0.096 1
Brugia malayi Peroxidasin 0.0135 0.1148 0.1777
Entamoeba histolytica hypothetical protein 0.0132 0.1123 0.335
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0165 0.1483 0.1483
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Echinococcus granulosus raf serine:threonine protein kinase 0.0132 0.1123 0.1737
Echinococcus granulosus protein kinase C gamma type 0.0486 0.4987 0.7715
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0148 0.129 0.1996
Schistosoma mansoni hypothetical protein 0.0037 0.0085 0.0131
Entamoeba histolytica protein kinase, putative 0.017 0.153 0.4694
Chlamydia trachomatis dihydrofolate reductase 0.0048 0.0201 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0135 0.1148 0.1148
Loa Loa (eye worm) thymidylate synthase 0.0117 0.096 0.096
Trichomonas vaginalis AGC family protein kinase 0.017 0.153 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0273 0.0273
Brugia malayi RhoGEF domain containing protein 0.0132 0.1123 0.1737
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0305 0.3014 0.4663
Echinococcus granulosus RNA directed DNA polymerase 0.0305 0.3014 0.4663
Brugia malayi hypothetical protein 0.0056 0.0288 0.0446
Trichomonas vaginalis AGC family protein kinase 0.0165 0.1483 0.9624
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1483 0.2295
Toxoplasma gondii dihydroorotase 0.0245 0.2352 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0621 0.6464 0.6464
Brugia malayi p70 ribosomal S6 kinase beta 0.0165 0.1483 0.2295
Loa Loa (eye worm) hypothetical protein 0.0132 0.1123 0.1123
Echinococcus multilocularis myotubularin protein 13 0.0137 0.1169 0.1809
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0165 0.1483 0.2295
Loa Loa (eye worm) hypothetical protein 0.0135 0.1148 0.1148
Echinococcus granulosus serine:threonine protein kinase N2 0.0312 0.3091 0.4782
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0132 0.1123 0.1737
Onchocerca volvulus Chorion peroxidase homolog 0.0135 0.1148 0.1402
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0117 0.096 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0618 0.6432 0.9949

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.49 nM Inhibitory activity against rat thoracic aorta contraction induced by 30 nM U-46619 ChEMBL. 2970551
IC50 (functional) = 1.4 nM Inhibitory activity against rat thoracic aorta contraction induced by 30 nM U-46619 ChEMBL. 2970551
IC50 (functional) = 1.8 nM Inhibition of rat washed platelet aggregation induced by 4 microg/mL of collagen ChEMBL. 2970551
IC50 (binding) = 2.3 nM Inhibition of thromboxane A2 synthetase from human platelets by 1 uM of the compound ChEMBL. 2970551
IC50 (binding) = 2.3 nM Inhibition of thromboxane A2 synthetase from human platelets by 1 uM of the compound ChEMBL. 2970551
IC50 (functional) = 2.9 nM Inhibition of rat washed platelet aggregation induced by 4 microg/mL of collagen ChEMBL. 2970551
IC50 (functional) = 13.4 nM Inhibition of rat washed platelet aggregation induced by 4 microg/mL of collagen ChEMBL. 2970551
IC50 (functional) = 15.3 nM Inhibitory activity against rat thoracic aorta contraction induced by 30 nM U-46619 ChEMBL. 2970551
IC50 (functional) = 0.6 uM Inhibition of rabbit platelet rich plasma aggregation induced by 500 microM of arachidonic acid ChEMBL. 2970551
IC50 (functional) = 1 uM Inhibition of rabbit platelet rich plasma aggregation induced by 500 microM of arachidonic acid ChEMBL. 2970551
IC50 (functional) = 7.4 uM Inhibition of rabbit platelet rich plasma aggregation induced by 500 microM of arachidonic acid ChEMBL. 2970551
Recovery (binding) = 2.1 % Inhibition of thromboxane A2 synthetase from human platelets by 10 uM of the compound expressed as percent of radioactivity recovered ChEMBL. 2970551
Recovery (binding) = 2.1 % Inhibition of thromboxane A2 synthetase from human platelets by 10 uM of the compound expressed as percent of radioactivity recovered ChEMBL. 2970551
Recovery (functional) = 14.2 % Effect on the synthesis of metabolities of arachidonic acid in human platelets at dose of 10 microM expressed as percent of radioactivity recovered ChEMBL. 2970551
Recovery (functional) = 14.2 % Effect on the synthesis of metabolities of arachidonic acid in human platelets at dose of 10 microM expressed as percent of radioactivity recovered ChEMBL. 2970551
Recovery (functional) = 14.3 % Effect on the synthesis of metabolities of arachidonic acid in human platelets at a dose of 1 microM ChEMBL. 2970551
Recovery (functional) = 14.3 % Effect on the synthesis of metabolities of arachidonic acid in human platelets at a dose of 1 microM ChEMBL. 2970551
Recovery (functional) = 23.2 % Effect on cyclooxygenase or lipoxygenase derived products (HHT and HETE) in human washed platelets at a dose of 10 microM as percent of radioactivity recovered ChEMBL. 2970551
Recovery (functional) = 23.2 % Effect on cyclooxygenase or lipoxygenase derived products (HHT and HETE) in human washed platelets at a dose of 10 microM as percent of radioactivity recovered ChEMBL. 2970551
Recovery (functional) = 24 % Effect on cyclooxygenase or lipoxygenase derived products(HHT and HETE) in human washed platelets at dose of 1 microM expressed as percent of radioactivity recovered ChEMBL. 2970551
Recovery (functional) = 24 % Effect on cyclooxygenase or lipoxygenase derived products(HHT and HETE) in human washed platelets at dose of 1 microM expressed as percent of radioactivity recovered ChEMBL. 2970551

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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