TDR Targets

Basic information

Technical information

TDR Targets ID: 780822
Name: 4-[[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3- yl]-(2-phenylethyl)amino]-4-oxobutanoic acid
MW: 428.866 | Formula: C22H21ClN2O5
H donors: 1 H acceptors: 5 LogP: 2.35 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCC(=O)N(C1CC(=O)N(C1=O)c1ccc(cc1)Cl)CCc1ccccc1
InChi: 1S/C22H21ClN2O5/c23-16-6-8-17(9-7-16)25-20(27)14-18(22(25)30)24(19(26)10-11-21(28)29)13-12-15-4-2-1-3-5-15/h1-9,18H,10-14H2,(H,28,29)
InChiKey: DQFKMTHXGBUEDH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[1-(4-chlorophenyl)-2,5-dioxo-pyrrolidin-3-yl]-(2-phenylethyl)amino]-4-oxo-butanoic acid
4-[[1-(4-chlorophenyl)-2,5-dioxo-3-pyrrolidinyl]-(2-phenylethyl)amino]-4-oxobutanoic acid
4-[[1-(4-chlorophenyl)-2,5-diketo-pyrrolidin-3-yl]-(2-phenylethyl)amino]-4-keto-butyric acid
N-[1-(4-Chloro-phenyl)-2,5-dioxo-pyrrolidin-3-yl]-N-phenethyl-succinamic acid
BIM-0032343.P001
BAS 00867339
A1914/0080459
CBMicro_032563

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0008	1	1
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0004	0	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0008	1	1
Leishmania major	dehydrogenase-like protein	0.0004	0	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	1	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0008	1	1
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.0008	1	1
Giardia lamblia	Hypothetical protein	0.0004	0	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0004	0	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0008	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	1	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0004	0	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	1	1
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0004	0	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0004	0	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0008	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0	0.5
Brugia malayi	nuclear hormone receptor	0.0008	1	1
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	1	1
Toxoplasma gondii	carbonyl reductase 1, putative	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	1	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0004	0	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0004	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	1	1
Toxoplasma gondii	oxidoreductase, putative	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	1	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0004	0	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0004	0	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0004	0	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0	0.5
Onchocerca volvulus		0.0008	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0004	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Entamoeba histolytica	hypothetical protein	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0008	1	1
Leishmania major	short chain dehydrogenase-like protein	0.0004	0	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	1	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0004	0	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0004	0	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0004	0	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0004	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Leishmania major	pteridine reductase 1	0.0004	0	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0004	0	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0004	0	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Giardia lamblia	Reductase, putative	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	1	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0004	0	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0004	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0008	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0	0.5
Brugia malayi	steroid hormone receptor	0.0008	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	1	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0004	0	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0004	0	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0008	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0008	1	1
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0004	0	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium ulcerans	dehydrogenase	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	1	1
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0004	0	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0004	0	0.5
Schistosoma mansoni	coup transcription factor	0.0008	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	1	1
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0004	0	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0004	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	1	1
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0008	1	1
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0004	0	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0004	0	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0004	0	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0004	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	1	1
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0004	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	1	1
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0004	0	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0004	0	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	1	1
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	1	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0004	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0004	0	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0004	0	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0004	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	1	1
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0004	0	0.5
Leishmania major	oxidoreductase-like protein	0.0004	0	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	1	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0004	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 780822