Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0046 | 0.077 | 0.1709 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0157 | 0.0168 |
Schistosoma mansoni | smad | 0.0025 | 0.0157 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0841 | 0.09 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0046 | 0.077 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0841 | 0.09 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0841 | 0.09 |
Mycobacterium leprae | conserved hypothetical protein | 0.0046 | 0.077 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0046 | 0.077 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0841 | 0.09 |
Echinococcus multilocularis | tar DNA binding protein | 0.0197 | 0.5078 | 0.5435 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0197 | 0.5078 | 0.5078 |
Plasmodium falciparum | carbonic anhydrase | 0.0083 | 0.1817 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0176 | 0.4503 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0157 | 0.0157 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0307 | 0.0329 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0155 | 0.3874 | 0.3874 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0368 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0981 | 0.202 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.1817 | 0.1817 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0307 | 0.0307 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0176 | 0.4503 | 0.4819 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0046 | 0.077 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0157 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0841 | 0.0841 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0157 | 0.0168 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0046 | 0.077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.247 | 0.247 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0157 | 0.0168 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0155 | 0.3874 | 0.3874 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0841 | 0.09 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0981 | 0.2179 |
Brugia malayi | Smad1 | 0.0025 | 0.0157 | 0.0157 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0176 | 0.4503 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1817 | 0.1817 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0307 | 0.0329 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.071 | 0.071 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0247 | 0.6521 | 0.6521 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0176 | 0.4503 | 0.4503 |
Echinococcus granulosus | smad | 0.0025 | 0.0157 | 0.0168 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0157 | 0.0168 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0176 | 0.4503 | 0.4503 |
Brugia malayi | hypothetical protein | 0.0119 | 0.2846 | 0.2846 |
Echinococcus granulosus | tar DNA binding protein | 0.0197 | 0.5078 | 0.5435 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0157 | 0.0168 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0307 | 0.0329 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.071 | 0.071 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0841 | 0.09 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.5078 | 0.5435 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2846 | 0.2846 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0176 | 0.4503 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0083 | 0.1817 | 0.1817 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1817 | 0.1817 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0157 | 0.0168 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0157 | 0.0157 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.076 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0157 | 0.0168 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0307 | 0.0329 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0841 | 0.0841 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0197 | 0.5078 | 0.5078 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0176 | 0.4503 | 0.4503 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0275 | 0.0295 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0083 | 0.1817 | 0.1817 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0981 | 0.0981 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0046 | 0.077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.3874 | 0.3874 |
Onchocerca volvulus | 0.0165 | 0.4173 | 0.6409 | |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0841 | 0.09 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0046 | 0.077 | 0.1709 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0155 | 0.3874 | 0.3874 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0046 | 0.077 | 0.306 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0307 | 0.0329 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0841 | 0.09 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0368 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.5078 | 0.5435 |
Echinococcus multilocularis | smad | 0.0025 | 0.0157 | 0.0168 |
Echinococcus granulosus | carbonic anhydrase II | 0.0176 | 0.4503 | 0.4819 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0157 | 0.0168 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0046 | 0.077 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0981 | 0.2179 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Entamoeba histolytica | hypothetical protein | 0.0046 | 0.077 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0157 | 0.0168 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0157 | 0.0157 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.5078 | 0.5435 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.071 | 0.076 |
Loa Loa (eye worm) | TAR-binding protein | 0.0197 | 0.5078 | 0.5078 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0165 | 0.4173 | 0.4466 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.071 | 0.076 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.013 | 0.0139 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0981 | 0.202 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0841 | 0.0841 |
Schistosoma mansoni | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0157 | 0.0157 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.5501 | 0.5501 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.1817 | 0.1817 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0083 | 0.1817 | 0.1817 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0841 | 0.09 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0307 | 0.0329 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0307 | 0.0307 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.5078 | 0.5435 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0046 | 0.077 | 0.306 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0046 | 0.077 | 0.6859 |
Toxoplasma gondii | hypothetical protein | 0.0083 | 0.1817 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0841 | 0.09 |
Onchocerca volvulus | 0.024 | 0.6339 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.9344 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0247 | 0.6521 | 0.6521 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.9344 | 1 |
Brugia malayi | RNA binding protein | 0.0197 | 0.5078 | 0.5078 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.013 | 0.0139 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.013 | 0.0139 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0157 | 0.0157 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0165 | 0.4173 | 0.4466 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0841 | 0.0841 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.1817 | 0.1817 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0307 | 0.0329 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.2846 | 0.4209 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0981 | 0.2179 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.1817 | 0.1945 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.1817 | 0.1945 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.2846 | 0.4209 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.071 | 0.076 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0981 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.1817 | 0.1945 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.5078 | 0.5435 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0176 | 0.4503 | 0.4503 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0165 | 0.4173 | 0.4466 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0176 | 0.4503 | 0.4819 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1817 | 0.1817 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0157 | 0.0168 |
Loa Loa (eye worm) | RNA binding protein | 0.0197 | 0.5078 | 0.5078 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.076 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.071 | 0.076 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.5501 | 0.5501 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0157 | 0.0157 |
Brugia malayi | TAR-binding protein | 0.0197 | 0.5078 | 0.5078 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0434 | 0.0434 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.1817 | 0.1945 |
Leishmania major | carbonic anhydrase-like protein | 0.0176 | 0.4503 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.1817 | 0.1945 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0981 | 0.4462 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0157 | 0.0157 |
Echinococcus multilocularis | geminin | 0.0345 | 0.9344 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0176 | 0.4503 | 0.4819 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0981 | 0.2179 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 0.6339 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0165 | 0.4173 | 0.4173 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.071 | 0.076 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2846 | 0.2846 |
Echinococcus granulosus | geminin | 0.0345 | 0.9344 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.247 | 0.2644 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0106 | 0.247 | 0.247 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.4173 | 0.4173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.