Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0183 | 0.1206 | 0.1388 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0104 | 0.0367 | 0.0976 |
Brugia malayi | Serotonin receptor | 0.0517 | 0.474 | 0.474 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0432 | 0.3843 | 0.4423 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0104 | 0.0367 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0174 | 0.1111 | 0.1279 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.0821 | 0.0945 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0151 | 0.0871 | 0.1003 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0871 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0151 | 0.0871 | 0.1003 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0367 | 0.0367 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0367 | 0.0367 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0578 | 0.5391 | 0.5391 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0575 | 0.5358 | 0.6166 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0183 | 0.1206 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1206 | 0.1206 |
Loa Loa (eye worm) | TAR-binding protein | 0.0783 | 0.7563 | 0.7563 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.1206 | 0.1595 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1013 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0166 | 0.103 | 0.1186 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.1206 | 0.1595 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.035 | 0.2978 | 0.3937 |
Loa Loa (eye worm) | hypothetical protein | 0.0578 | 0.5391 | 0.5391 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.2581 | 0.2581 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0871 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0395 | 0.3454 | 0.3454 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0871 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0104 | 0.0367 | 0.0976 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0174 | 0.1111 | 0.1279 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.0821 | 0.0821 |
Brugia malayi | hypothetical protein | 0.0151 | 0.0871 | 0.0871 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0183 | 0.1206 | 0.1206 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1111 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0821 | 0.0821 |
Echinococcus multilocularis | GPCR, family 2 | 0.0183 | 0.1206 | 0.1388 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0254 | 0.1956 | 1 |
Brugia malayi | RNA binding protein | 0.0783 | 0.7563 | 0.7563 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.1956 | 0.1956 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0104 | 0.0367 | 0.0976 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.1206 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.0871 | 0.1152 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.035 | 0.2978 | 0.2978 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0578 | 0.5391 | 0.5391 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0104 | 0.0367 | 0.0976 |
Echinococcus granulosus | tar DNA binding protein | 0.0783 | 0.7563 | 0.8703 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.089 | 0.8689 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0783 | 0.7563 | 0.7563 |
Schistosoma mansoni | tar DNA-binding protein | 0.0783 | 0.7563 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0783 | 0.7563 | 0.7563 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0254 | 0.1956 | 1 |
Brugia malayi | hypothetical protein | 0.0295 | 0.2392 | 0.2392 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.0871 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0183 | 0.1206 | 0.1206 |
Schistosoma mansoni | hypothetical protein | 0.0395 | 0.3454 | 0.4567 |
Schistosoma mansoni | tar DNA-binding protein | 0.0783 | 0.7563 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0432 | 0.3843 | 0.4423 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0575 | 0.5358 | 0.6166 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.2251 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.2978 | 0.2978 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0578 | 0.5391 | 0.5391 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0254 | 0.1956 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0254 | 0.1956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1111 | 0.1111 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0432 | 0.3843 | 0.5082 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0166 | 0.103 | 0.1186 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0183 | 0.1206 | 0.1388 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.0821 | 0.0945 |
Brugia malayi | Dopamine receptor protein 1 | 0.047 | 0.4247 | 0.4247 |
Echinococcus granulosus | GPCR family 2 | 0.0183 | 0.1206 | 0.1388 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0183 | 0.1206 | 0.1388 |
Echinococcus multilocularis | tar DNA binding protein | 0.0783 | 0.7563 | 0.8703 |
Onchocerca volvulus | 0.0295 | 0.2392 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.4247 | 0.4247 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.173 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0151 | 0.0871 | 0.1152 |
Brugia malayi | TAR-binding protein | 0.0783 | 0.7563 | 0.7563 |
Echinococcus multilocularis | serotonin receptor | 0.0174 | 0.1111 | 0.1279 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.1206 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.4247 | 0.4247 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0783 | 0.7563 | 0.7563 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0174 | 0.1111 | 0.1469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0783 | 0.7563 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.089 | 0.8689 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0166 | 0.103 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.4247 | 0.4247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0783 | 0.7563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0821 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3454 | 0.3454 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0104 | 0.0367 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.2251 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.1431 | 0.1431 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0166 | 0.103 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0183 | 0.1206 | 0.1206 |
Schistosoma mansoni | tar DNA-binding protein | 0.0783 | 0.7563 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0166 | 0.103 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0104 | 0.0367 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.2392 | 0.2392 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0254 | 0.1956 | 0.2587 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.2978 | 0.2978 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0254 | 0.1956 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.1431 | 0.1431 |
Brugia malayi | Probable ClpP-like protease | 0.0254 | 0.1956 | 0.1956 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0.0367 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.0821 | 0.0945 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1013 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.