Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0061 | 0.0629 | 0.3839 |
Schistosoma mansoni | acetylcholinesterase | 0.0127 | 0.1506 | 0.1522 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0061 | 0.0629 | 0.3839 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0127 | 0.1506 | 0.1522 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0127 | 0.1506 | 0.1522 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0061 | 0.0629 | 0.3839 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0127 | 0.1506 | 0.1522 |
Onchocerca volvulus | 0.0127 | 0.1506 | 0.5 | |
Onchocerca volvulus | 0.0127 | 0.1506 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0127 | 0.1506 | 0.1522 |
Echinococcus multilocularis | acetylcholinesterase | 0.0752 | 0.9856 | 0.9856 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0043 | 0.0383 | 0.0382 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0043 | 0.0383 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0061 | 0.0629 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0021 | 0.0083 | 0.6433 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0125 | 0.19 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0125 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.004 | 0.034 | 0.0338 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0013 | 0.0006 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0021 | 0.0083 | 0.0077 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0043 | 0.0383 | 0.0382 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0125 | 0.012 |
Brugia malayi | Carboxylesterase family protein | 0.0127 | 0.1506 | 0.1522 |
Echinococcus granulosus | neuroligin | 0.0127 | 0.1506 | 0.1522 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0049 | 0.0461 | 0.6931 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0125 | 0.19 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0116 | 0.1352 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.9856 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.9856 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0752 | 0.9856 | 0.9856 |
Echinococcus multilocularis | acetylcholinesterase | 0.0752 | 0.9856 | 0.9856 |
Echinococcus granulosus | acetylcholinesterase | 0.0752 | 0.9856 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0043 | 0.0383 | 0.0382 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0127 | 0.1506 | 0.15 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0125 | 0.012 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0027 | 0.0172 | 0.1637 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0019 | 0.0058 | 0.0831 |
Schistosoma mansoni | gliotactin | 0.0127 | 0.1506 | 0.1522 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0103 | 0.1184 | 0.1196 |
Loa Loa (eye worm) | carboxylesterase | 0.0752 | 0.9856 | 1 |
Onchocerca volvulus | 0.0127 | 0.1506 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0125 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.004 | 0.034 | 0.0338 |
Entamoeba histolytica | hypothetical protein | 0.0049 | 0.0461 | 0.6931 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0043 | 0.0383 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0097 | 0.0092 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0042 | 0.0372 | 0.2032 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.006 | 0.0605 | 0.9555 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0125 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0127 | 0.1506 | 0.1522 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0054 | 0.0531 | 0.0533 |
Onchocerca volvulus | 0.0127 | 0.1506 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0127 | 0.1506 | 0.1522 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0127 | 0.1506 | 0.1522 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0116 | 0.1352 | 0.1366 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0043 | 0.0383 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0116 | 0.1352 | 0.1366 |
Brugia malayi | Carboxylesterase family protein | 0.0127 | 0.1506 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0112 | 0.1309 | 0.1322 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.003 | 0.0204 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0061 | 0.0629 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0205 | 0.2545 | 0.2577 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0127 | 0.1506 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0752 | 0.9856 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0127 | 0.1506 | 0.1522 |
Brugia malayi | Carboxylesterase family protein | 0.0127 | 0.1506 | 0.1522 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0125 | 1 |
Brugia malayi | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0043 | 0.0383 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0127 | 0.1506 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0127 | 0.1506 | 0.1522 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0058 | 0.0053 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0127 | 0.1506 | 0.15 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0061 | 0.0629 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0042 | 0.0372 | 0.2032 |
Brugia malayi | Carboxylesterase family protein | 0.0752 | 0.9856 | 1 |
Onchocerca volvulus | 0.0127 | 0.1506 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0112 | 0.1309 | 0.1322 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0021 | 0.0083 | 0.0077 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0127 | 0.1506 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0125 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0752 | 0.9856 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0127 | 0.1506 | 0.1522 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0127 | 0.1506 | 0.15 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1506 | 0.1522 |
Brugia malayi | follicle stimulating hormone receptor | 0.0205 | 0.2545 | 0.2577 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0043 | 0.0383 | 0.0382 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0752 | 0.9856 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0127 | 0.1506 | 0.1522 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0043 | 0.0383 | 0.0377 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0061 | 0.0629 | 0.0632 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0021 | 0.0083 | 0.1222 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0127 | 0.1506 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0127 | 0.1506 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0112 | 0.1309 | 0.1322 |
Echinococcus multilocularis | neuroligin | 0.0127 | 0.1506 | 0.15 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.034 | 0.0338 |
Echinococcus granulosus | carboxylesterase 5A | 0.0752 | 0.9856 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0127 | 0.1506 | 0.5 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.004 | 0.034 | 0.0333 |
Brugia malayi | Carboxylesterase family protein | 0.0752 | 0.9856 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0125 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.