Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.0753 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3183 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.3183 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3183 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3183 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3183 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0538 | 0.1532 | 0.1532 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Plasmodium vivax | plasmepsin V, putative | 0.01 | 0.0131 | 0.5 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.01 | 0.0131 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0538 | 0.1532 | 0.142 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3183 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0294 | 0.0753 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.0307 | 0.2003 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Plasmodium falciparum | plasmepsin I | 0.01 | 0.0131 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.01 | 0.0131 | 0.5 |
Plasmodium falciparum | plasmepsin VII | 0.01 | 0.0131 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Onchocerca volvulus | 0.0538 | 0.1532 | 1 | |
Brugia malayi | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Schistosoma mansoni | acetylcholinesterase | 0.0538 | 0.1532 | 0.1532 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.01 | 0.0131 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.01 | 0.0131 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3183 | 1 | 1 |
Toxoplasma gondii | aspartyl protease | 0.01 | 0.0131 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.0307 | 0.2003 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.01 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0538 | 0.1532 | 0.1532 |
Plasmodium vivax | aspartyl protease, putative | 0.01 | 0.0131 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Plasmodium vivax | aspartyl protease, putative | 0.01 | 0.0131 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.01 | 0.0131 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.01 | 0.0131 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0538 | 0.1532 | 0.1532 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.01 | 0.0131 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.01 | 0.0131 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3183 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0538 | 0.1532 | 0.1532 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0339 | 0.0339 |
Brugia malayi | Carboxylesterase family protein | 0.0538 | 0.1532 | 0.142 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0538 | 0.1532 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.0753 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Onchocerca volvulus | 0.0538 | 0.1532 | 1 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Echinococcus multilocularis | acetylcholinesterase | 0.3183 | 1 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.01 | 0.0131 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0538 | 0.1532 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0538 | 0.1532 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0339 | 0.0339 |
Onchocerca volvulus | 0.0538 | 0.1532 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.3183 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3183 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0538 | 0.1532 | 0.1532 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.3183 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0538 | 0.1532 | 1 |
Plasmodium falciparum | plasmepsin II | 0.01 | 0.0131 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.01 | 0.0131 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.01 | 0.0131 | 0.0131 |
Echinococcus granulosus | neuroligin | 0.0538 | 0.1532 | 0.1532 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.01 | 0.0131 | 0.0131 |
Onchocerca volvulus | 0.0538 | 0.1532 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0538 | 0.1532 | 0.142 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0339 | 0.0339 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0256 | 0.3407 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.01 | 0.0131 | 0.0131 |
Brugia malayi | Carboxylesterase family protein | 0.0538 | 0.1532 | 0.142 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.01 | 0.0131 | 0.0131 |
Plasmodium falciparum | plasmepsin X | 0.01 | 0.0131 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.01 | 0.0131 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0538 | 0.1532 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Echinococcus granulosus | geminin | 0.0165 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.1532 | 0.142 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0294 | 0.0753 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.01 | 0.0131 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0538 | 0.1532 | 0.1532 |
Brugia malayi | Carboxylesterase family protein | 0.0538 | 0.1532 | 0.142 |
Loa Loa (eye worm) | carboxylesterase | 0.0538 | 0.1532 | 0.142 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0538 | 0.1532 | 0.1532 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.2491 | 0.7785 | 0.7785 |
Plasmodium falciparum | plasmepsin III | 0.01 | 0.0131 | 0.5 |
Onchocerca volvulus | 0.0538 | 0.1532 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0538 | 0.1532 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.01 | 0.0131 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.