Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Protein kinase C gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Protein kinase C gamma | 697 aa | 665 aa | 60.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.1562 | 0.1977 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.6646 | 0.6646 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.1293 | 0.1293 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.1562 | 0.1562 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.2841 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.6646 | 0.6646 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4836 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.6646 | 0.6646 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.6646 | 0.841 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4836 | 0.4836 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.2841 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.6609 | 0.8363 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.1562 | 0.1562 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.6917 | 0.8753 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.7902 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.821 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.2841 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.8707 | 0.8707 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.6646 | 0.6646 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0265 | 0.0265 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.6609 | 0.6609 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2841 | 0.346 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.1562 | 0.1903 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.8707 | 0.8707 |
Brugia malayi | hypothetical protein | 0.0017 | 0.1186 | 0.1444 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4836 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2841 | 0.3595 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.4836 | 0.4836 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.6646 | 0.8094 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.2841 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4836 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0265 | 0.0265 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.1562 | 0.1562 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.2841 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.1293 | 0.1293 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.6646 | 0.6646 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.2841 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.4836 | 0.4836 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.2841 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.6646 | 0.6646 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.1293 | 0.1293 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.4836 | 0.4836 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.6609 | 0.6609 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.4836 | 0.5891 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.6609 | 0.6609 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.2841 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4836 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.6646 | 0.6646 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0265 | 0.0265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of rat brain protein kinase C (PKC) with ATP and histone as substrates | ChEMBL. | 1732526 |
IC50 (binding) | = 2 uM | Inhibition of rat brain protein kinase C (PKC) with ATP and histone as substrates | ChEMBL. | 1732526 |
IC50 (binding) | > 100 uM | Inhibition of bovine cAMP-dependent protein kinase A. | ChEMBL. | 1732526 |
Selectivity (binding) | > 50 | Selectivity ratio (IC50 PKA divided by IC50 PKC). | ChEMBL. | 1732526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.