TDR Targets

Basic information

Technical information

TDR Targets ID: 781476
Name: 2-diethylamino-N-(6-methyl-2,1,3-benzothiadia zol-7-yl)acetamide
MW: 278.373 | Formula: C13H18N4OS
H donors: 1 H acceptors: 3 LogP: 2.13 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CC(=O)Nc1c(C)ccc2c1nsn2)CC
InChi: 1S/C13H18N4OS/c1-4-17(5-2)8-11(18)14-12-9(3)6-7-10-13(12)16-19-15-10/h6-7H,4-5,8H2,1-3H3,(H,14,18)
InChiKey: KXTSTAODBBADJF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-diethylamino-N-(5-methylpiazthiol-4-yl)acetamide
2-diethylamino-N-(6-methyl-2,1,3-benzothiadiazol-7-yl)ethanamide
A3912/0166382

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0052	0.1469	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.1469	0.1469
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.1469	0.1469
Loa Loa (eye worm)	carboxylesterase	0.0052	0.1469	0.1469
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1805	0.1805
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1805	0.1805
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0052	0.1469	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0309	1	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1805	0.1805
Onchocerca volvulus		0.0052	0.1469	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0309	1	1
Echinococcus granulosus	neuroligin	0.0052	0.1469	0.1469
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1247	0.1247
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1247	0.1247
Echinococcus multilocularis	carboxylesterase 5A	0.0309	1	1
Echinococcus granulosus	carboxylesterase 5A	0.0309	1	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0052	0.1469	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.1469	0.1469
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.1247	0.1247
Brugia malayi	Carboxylesterase family protein	0.0052	0.1469	0.1469
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.3637	0.3637
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1805	0.1805
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1805	0.1805
Onchocerca volvulus		0.0052	0.1469	0.5
Schistosoma mansoni	BC026374 protein (S09 family)	0.0052	0.1469	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0309	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1247	0.1247
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0052	0.1469	0.1469
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0052	0.1469	0.5
Brugia malayi	MH2 domain containing protein	0.0118	0.3637	0.3637
Echinococcus multilocularis	acetylcholinesterase	0.0309	1	1
Brugia malayi	Carboxylesterase family protein	0.0052	0.1469	0.1469
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1805	0.1805
Echinococcus granulosus	acetylcholinesterase	0.0309	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1247	0.1247
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1805	0.1805
Loa Loa (eye worm)	carboxylesterase	0.0309	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1805	0.1805
Brugia malayi	TAR-binding protein	0.0062	0.1805	0.1805
Brugia malayi	hypothetical protein	0.0052	0.1469	0.1469
Onchocerca volvulus		0.0052	0.1469	0.5
Brugia malayi	RNA binding protein	0.0062	0.1805	0.1805
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.3637	0.3637
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Echinococcus granulosus	BC026374 protein S09 family	0.0052	0.1469	0.1469
Trichomonas vaginalis	spcc417.12 protein, putative	0.0052	0.1469	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1247	0.1247
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1805	0.1805
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0052	0.1469	0.1469
Echinococcus multilocularis	para nitrobenzyl esterase	0.0052	0.1469	0.1469
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1805	0.1805
Brugia malayi	Carboxylesterase family protein	0.0052	0.1469	0.1469
Brugia malayi	Carboxylesterase family protein	0.0052	0.1469	0.1469
Echinococcus multilocularis	neuroligin	0.0052	0.1469	0.1469
Brugia malayi	Carboxylesterase family protein	0.0309	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Schistosoma mansoni	acetylcholinesterase	0.0052	0.1469	0.1469
Mycobacterium ulcerans	carboxylesterase, LipT	0.0052	0.1469	0.5
Echinococcus granulosus	acetylcholinesterase	0.0309	1	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0052	0.1469	0.1469
Echinococcus multilocularis	acetylcholinesterase	0.0309	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Onchocerca volvulus		0.0052	0.1469	0.5
Echinococcus granulosus	para nitrobenzyl esterase	0.0052	0.1469	0.1469
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1805	0.1805
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.1247	0.1247
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0052	0.1469	0.5
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0052	0.1469	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1469	0.1469
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1247	0.1247
Schistosoma mansoni	gliotactin	0.0052	0.1469	0.1469
Loa Loa (eye worm)	acetylcholinesterase 1	0.0309	1	1
Loa Loa (eye worm)	carboxylesterase	0.0052	0.1469	0.1469

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 781476