Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.9254 | 1 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0333 | 0.0173 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3186 | 0.4188 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.7332 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0199 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0851 | 0.0914 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0199 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0518 | 0.0411 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4357 | 0.4709 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0333 | 0.0188 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0199 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0851 | 0.084 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0199 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0199 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0199 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0199 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0333 | 0.0188 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3611 | 0.3902 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0199 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0518 | 0.0559 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0851 | 0.0914 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.7956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4024 | 0.4348 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3186 | 0.4188 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.7332 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0199 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0199 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0199 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0199 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.3599 | 0.3469 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0199 | 0.0215 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1264 | 0.1086 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0199 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.