Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0143 | 0.0887 | 1 |
Echinococcus granulosus | neuroligin | 0.0187 | 0.1299 | 0.1299 |
Onchocerca volvulus | 0.0187 | 0.1299 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1106 | 1 | 1 |
Onchocerca volvulus | 0.0187 | 0.1299 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0187 | 0.1299 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1106 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1299 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1299 | 0.1299 |
Loa Loa (eye worm) | carboxylesterase | 0.1106 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0187 | 0.1299 | 0.1299 |
Onchocerca volvulus | 0.0187 | 0.1299 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Leishmania major | trypanothione reductase | 0.0143 | 0.0887 | 1 |
Onchocerca volvulus | 0.0187 | 0.1299 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0187 | 0.1299 | 0.1299 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0143 | 0.0887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0187 | 0.1299 | 1 |
Treponema pallidum | NADH oxidase | 0.005 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1106 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.005 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0143 | 0.0887 | 0.6831 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Echinococcus multilocularis | acetylcholinesterase | 0.1106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1106 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0143 | 0.0887 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0143 | 0.0887 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0143 | 0.0887 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0143 | 0.0887 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.005 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.005 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0187 | 0.1299 | 0.1299 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0438 | 0.3678 | 0.3678 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Schistosoma mansoni | acetylcholinesterase | 0.0187 | 0.1299 | 0.1299 |
Brugia malayi | Thioredoxin reductase | 0.0143 | 0.0887 | 0.0887 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0143 | 0.0887 | 0.0887 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Brugia malayi | Carboxylesterase family protein | 0.1106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1299 | 0.0452 |
Echinococcus multilocularis | neuroligin | 0.0187 | 0.1299 | 0.1299 |
Echinococcus granulosus | acetylcholinesterase | 0.1106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1106 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0187 | 0.1299 | 0.0452 |
Schistosoma mansoni | gliotactin | 0.0187 | 0.1299 | 0.1299 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0187 | 0.1299 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0187 | 0.1299 | 0.1299 |
Loa Loa (eye worm) | carboxylesterase | 0.0187 | 0.1299 | 0.0452 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1299 | 0.1299 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0187 | 0.1299 | 0.1299 |
Echinococcus multilocularis | acetylcholinesterase | 0.1106 | 1 | 1 |
Onchocerca volvulus | 0.0187 | 0.1299 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0187 | 0.1299 | 0.1299 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0187 | 0.1299 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0143 | 0.0887 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1106 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0187 | 0.1299 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1106 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0187 | 0.1299 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0143 | 0.0887 | 0.0887 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1299 | 0.1299 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.005 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0143 | 0.0887 | 0.0887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.