Detailed information for compound 781793

Basic information

Technical information
  • TDR Targets ID: 781793
  • Name: 2-[(2,5-dimethylphenyl)amino]-N-(2-methoxyeth yl)quinoline-4-carboxamide
  • MW: 349.426 | Formula: C21H23N3O2
  • H donors: 2 H acceptors: 2 LogP: 3.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)c1cc(Nc2cc(C)ccc2C)nc2c1cccc2
  • InChi: 1S/C21H23N3O2/c1-14-8-9-15(2)19(12-14)24-20-13-17(21(25)22-10-11-26-3)16-6-4-5-7-18(16)23-20/h4-9,12-13H,10-11H2,1-3H3,(H,22,25)(H,23,24)
  • InChiKey: IQHICGYWVAHLAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2,5-dimethylphenyl)amino]-N-(2-methoxyethyl)-4-quinolinecarboxamide
  • 2-[(2,5-dimethylphenyl)amino]-N-(2-methoxyethyl)cinchoninamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0027 0.2354
Loa Loa (eye worm) hypothetical protein 0.1575 0.3491 0.3491
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0077 0.0341
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0027 0.0042
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0763 0.1682 0.1682
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0093 0.0093
Onchocerca volvulus 0.0018 0.002 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0062 0.0847
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Onchocerca volvulus 0.0266 0.0574 0.0571
Onchocerca volvulus 0.0763 0.1682 0.1679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0062 0.5
Treponema pallidum sodium- and chloride- dependent transporter 0.4496 1 1
Echinococcus multilocularis carboxylesterase 5A 0.1575 0.3491 0.3491
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.8618
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Echinococcus multilocularis serotonin transporter 0.4496 1 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0062 0.0627
Loa Loa (eye worm) carboxylesterase 0.0266 0.0574 0.0574
Schistosoma mansoni alpha-glucosidase 0.0154 0.0325 0.0325
Onchocerca volvulus 0.0763 0.1682 0.1679
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0033 0.0074
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0086 0.0394
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0033 0.3285
Loa Loa (eye worm) hypothetical protein 0.0023 0.0033 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0045 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0004 0.0004
Plasmodium vivax amine transporter, putative 0.0763 0.1682 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.007 0.007
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.007 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0062 0.852
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0266 0.0574 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.8618
Echinococcus multilocularis acetylcholinesterase 0.1575 0.3491 0.3491
Echinococcus multilocularis muscleblind protein 0.0304 0.0659 0.0659
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0004 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0062 0.0847
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Echinococcus granulosus sodium and chloride dependent glycine 0.0763 0.1682 0.1682
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0004 0.0004
Onchocerca volvulus 0.0104 0.0212 0.0209
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0004 0.0004
Onchocerca volvulus 0.0266 0.0574 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0004 0.0004
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0763 0.1682 0.1682
Onchocerca volvulus 0.0036 0.0062 0.0058
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0266 0.0574 0.0574
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0062 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0763 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0018 0.002 0.002
Onchocerca volvulus 0.0036 0.0062 0.0058
Brugia malayi ecdysteroid receptor 0.001 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0093 0.0093
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0014 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0027 0.2354
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.8618
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0266 0.0574 0.0574
Brugia malayi MH2 domain containing protein 0.0123 0.0256 0.0256
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0014 0.001
Schistosoma mansoni nuclear hormone receptor 0.001 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0036 0.0062 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0004 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0062 0.0847
Mycobacterium tuberculosis Carboxylesterase LipT 0.0266 0.0574 1
Brugia malayi beta-lactamase family protein 0.0036 0.0062 0.0062
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0004 0.0004
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0763 0.1682 0.1682
Schistosoma mansoni cathepsin D (A01 family) 0.0018 0.002 0.002
Brugia malayi Muscleblind-like protein 0.0304 0.0659 0.0659
Brugia malayi Eukaryotic aspartyl protease family protein 0.0018 0.002 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0039 0.0068 0.0068
Echinococcus granulosus carboxylesterase 5A 0.1575 0.3491 0.3491
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.1575 0.3491 0.3491
Schistosoma mansoni cathepsin D (A01 family) 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0266 0.0574 1
Brugia malayi Pepsin A precursor 0.0018 0.002 0.002
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0018 0.002 0.0108
Brugia malayi hypothetical protein 0.0763 0.1682 0.1682
Schistosoma mansoni sodium/chloride dependent transporter 0.0763 0.1682 0.1682
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0036 0.0062 0.0627
Brugia malayi Carboxylesterase family protein 0.1575 0.3491 0.3491
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0062 0.0627
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0018 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0029 0.0045 0.0045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0027 0.2354
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0093 0.0093
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0062 0.0627
Schistosoma mansoni coup transcription factor 0.001 0.0004 0.0004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0763 0.1682 0.1682
Echinococcus granulosus sodium and chloride dependent glycine 0.0763 0.1682 0.1682
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0004
Schistosoma mansoni alpha glucosidase 0.004 0.007 0.007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0337 0.0337
Toxoplasma gondii ABC1 family protein 0.0036 0.0062 0.0249
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0004 0.0004
Echinococcus granulosus geminin 0.0362 0.0787 0.0787
Leishmania major hypothetical protein, conserved 0.0036 0.0062 0.852
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1575 0.3491 0.3491
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.0268 0.0579 0.0579
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0062 0.0627
Mycobacterium ulcerans beta-lactamase 0.0036 0.0062 0.0627
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.4496 1 1
Plasmodium falciparum transporter, putative 0.0763 0.1682 1
Brugia malayi hypothetical protein 0.0266 0.0574 0.0574
Schistosoma mansoni memapsin-2 (A01 family) 0.0437 0.0955 0.0955
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0763 0.1682 0.1682
Onchocerca volvulus 0.0763 0.1682 0.1679
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.007 0.0994
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.0381 0.0381
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0004 0.0004
Echinococcus multilocularis para nitrobenzyl esterase 0.0266 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Brugia malayi Carboxylesterase family protein 0.0266 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Echinococcus multilocularis BC026374 protein (S09 family) 0.0266 0.0574 0.0574
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0004 0.0004
Toxoplasma gondii exonuclease III APE 0.0021 0.0027 0.0042
Echinococcus granulosus muscleblind protein 0.0304 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0266 0.0574 0.0574
Echinococcus granulosus cpg binding protein 0.003 0.0049 0.0049
Loa Loa (eye worm) beta-lactamase 0.0036 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0268 0.0579 0.0579
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.4496 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0112 0.0549
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0093 0.0093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0004 0.0004
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0337 0.0337
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.007 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.007 0.0994
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0062 0.0847
Onchocerca volvulus 0.0036 0.0062 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0004 0.0004
Schistosoma mansoni BC026374 protein (S09 family) 0.0266 0.0574 0.0574
Echinococcus granulosus microtubule associated protein 2 0.075 0.1653 0.1653
Mycobacterium tuberculosis Conserved protein 0.0036 0.0062 0.0627
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0763 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus FTZ F1 alpha 0.001 0.0004 0.0004
Loa Loa (eye worm) norepinephrine transporter 0.4496 1 1
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Brugia malayi hypothetical protein 0.0023 0.0033 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0027 0.2354
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.007 0.0994
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0086 0.0394
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0018 0.002 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.007 0.0994
Trypanosoma brucei glucosidase, putative 0.004 0.007 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0763 0.1682 0.1682
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.007 0.0994
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0004 0.0004
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0077 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Loa Loa (eye worm) serotonin transporter b 0.4496 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.007 0.007
Echinococcus granulosus para nitrobenzyl esterase 0.0266 0.0574 0.0574
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0362 0.0787 0.0787
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0027 0.0234
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0004 0.0004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0763 0.1682 0.1682
Brugia malayi Carboxylesterase family protein 0.0266 0.0574 0.0574
Toxoplasma gondii hypothetical protein 0.0763 0.1682 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0062 0.852
Onchocerca volvulus 0.0266 0.0574 0.0571
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0062 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Loa Loa (eye worm) carboxylesterase 0.0266 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0027 0.0027
Mycobacterium ulcerans carboxylesterase, LipT 0.0266 0.0574 1
Echinococcus multilocularis geminin 0.0362 0.0787 0.0787
Schistosoma mansoni ap endonuclease 0.0021 0.0027 0.0027
Echinococcus multilocularis sodium and chloride dependent glycine 0.0763 0.1682 0.1682
Schistosoma mansoni hypothetical protein 0.0362 0.0787 0.0787
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0027 0.0027
Schistosoma mansoni neuroligin 3 (S09 family) 0.0266 0.0574 0.0574
Onchocerca volvulus Huntingtin homolog 0.0268 0.0579 0.0575
Echinococcus granulosus BC026374 protein S09 family 0.0266 0.0574 0.0574
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0256 0.0256
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0033 0.3285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0093 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.075 0.1653 0.1653
Entamoeba histolytica hypothetical protein 0.0039 0.0068 0.8618
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0763 0.1682 1
Echinococcus granulosus serotonin transporter 0.4496 1 1
Echinococcus granulosus acetylcholinesterase 0.1575 0.3491 0.3491
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0062 0.0627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0093 0.0093
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0062 0.0627
Loa Loa (eye worm) solute carrier family 6 member 4 0.4496 1 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0763 0.1682 0.1682
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0068 0.0068
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0337 0.0337
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0763 0.1682 0.1682
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0068 0.0068
Brugia malayi Carboxylesterase family protein 0.1575 0.3491 0.3491
Brugia malayi hypothetical protein 0.0015 0.0014 0.0014
Leishmania major alpha glucosidase II subunit, putative 0.004 0.007 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0018 0.002 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.0381 0.0381
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0062 0.0062
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Onchocerca volvulus 0.0266 0.0574 0.0571
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.007 0.0994
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Loa Loa (eye worm) acetylcholinesterase 1 0.1575 0.3491 0.3491
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0062 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0062 0.0627
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0004 0.0004
Schistosoma mansoni sodium/chloride dependent transporter 0.4496 1 1
Schistosoma mansoni acetylcholinesterase 0.0266 0.0574 0.0574
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0062 0.0062
Echinococcus multilocularis cpg binding protein 0.003 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) aspartyl protease 6 0.0018 0.002 0.002
Brugia malayi hypothetical protein 0.0039 0.0068 0.0068
Echinococcus granulosus acetylcholinesterase 0.1575 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0266 0.0574 0.0574
Echinococcus granulosus neuroligin 0.0266 0.0574 0.0574
Plasmodium vivax hypothetical protein, conserved 0.0763 0.1682 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0266 0.0574 0.0574
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0027 0.2086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0062 0.0627
Mycobacterium leprae Probable lipase LipE 0.0036 0.0062 0.5
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0077 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0018 0.002 0.002
Onchocerca volvulus 0.0266 0.0574 0.0571
Schistosoma mansoni cpg binding protein 0.003 0.0049 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0763 0.1682 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0495 0.8552
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.007 0.0994
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.007 0.886
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0763 0.1682 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0004 0.0004
Onchocerca volvulus 0.0018 0.002 0.0017
Mycobacterium tuberculosis Conserved protein 0.0036 0.0062 0.0627
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0033 0.0074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0763 0.1682 0.1682
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.007 0.0994
Echinococcus multilocularis neuroligin 0.0266 0.0574 0.0574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0093 0.0093
Echinococcus multilocularis muscleblind protein 1 0.0304 0.0659 0.0659
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0004 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0062 0.0062
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.007 0.886
Echinococcus multilocularis sodium and chloride dependent glycine 0.0763 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.4496 1 1
Brugia malayi nuclear hormone receptor 0.001 0.0004 0.0004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0027 0.0234
Brugia malayi steroid hormone receptor 0.001 0.0004 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0004 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0086 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0023 0.0033 0.3285
Plasmodium falciparum amino acid transporter, putative 0.0763 0.1682 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0266 0.0574 0.0574
Trichomonas vaginalis esterase, putative 0.0036 0.0062 0.0847
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Brugia malayi beta-lactamase family protein 0.0036 0.0062 0.0062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0004 0.0004
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.007 0.0994
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0266 0.0574 1
Echinococcus multilocularis acetylcholinesterase 0.1575 0.3491 0.3491
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.0381 0.0381
Schistosoma mansoni alpha-glucosidase 0.0154 0.0325 0.0325
Schistosoma mansoni thyroid hormone receptor 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0062 0.0627
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0004 0.0004
Onchocerca volvulus Huntingtin homolog 0.0268 0.0579 0.0575
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0027 0.0027
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0086 0.0394
Loa Loa (eye worm) carboxylesterase 0.1575 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.4496 1 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0021 0.0027 0.0027
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0256 0.0256
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0086 0.1277
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.002 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0062 0.0249
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Schistosoma mansoni gliotactin 0.0266 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0763 0.1682 0.1682
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0062 0.852
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0763 0.1682 0.1682
Loa Loa (eye worm) acetyltransferase 0.016 0.0337 0.0337
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0062 0.0847
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0004 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.003 0.0049 0.0049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0117 0.0117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0304 0.0659 0.0659
Trichomonas vaginalis spcc417.12 protein, putative 0.0266 0.0574 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0004 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0327 0.0327
Schistosoma mansoni microtubule-associated protein tau 0.075 0.1653 0.1653
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.007 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0004
Toxoplasma gondii hypothetical protein 0.0763 0.1682 1
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.007 0.007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0027 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0086 0.1277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0004 0.0004
Onchocerca volvulus 0.0029 0.0045 0.0042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0027 0.0042
Schistosoma mansoni sodium/chloride dependent transporter 0.0763 0.1682 0.1682
Schistosoma mansoni thyroid hormone receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0004 0.0004
Brugia malayi Carboxylesterase family protein 0.0266 0.0574 0.0574
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0763 0.1682 0.1682
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0033 0.0074
Brugia malayi Carboxylesterase family protein 0.0266 0.0574 0.0574
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0033 0.3285
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0763 0.1682 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0004 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0763 0.1682 0.1682
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0033 0.0074
Loa Loa (eye worm) hypothetical protein 0.0304 0.0659 0.0659
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0062 0.0062
Onchocerca volvulus 0.4496 1 1
Brugia malayi beta-lactamase 0.0036 0.0062 0.0062
Brugia malayi aspartic protease BmAsp-2, identical 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0268 0.0579 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0004 0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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