Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.005 | 0.0357 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0193 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.3369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0785 | 0.233 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0357 | 0.0357 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0357 | 0.0915 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0357 | 0.1058 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.019 | 0.0166 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.0485 | 0.0462 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.005 | 0.0357 | 0.0357 |
Echinococcus granulosus | serotonin transporter | 0.0085 | 0.0785 | 0.0763 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0193 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.0485 | 0.0462 |
Schistosoma mansoni | gliotactin | 0.005 | 0.0357 | 0.0357 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.005 | 0.0357 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.019 | 0.0166 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0295 | 0.3369 | 0.3369 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0295 | 0.3369 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.005 | 0.0357 | 0.0334 |
Echinococcus multilocularis | serotonin transporter | 0.0085 | 0.0785 | 0.0763 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0193 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0193 | 0.0421 |
Onchocerca volvulus | 0.0085 | 0.0785 | 0.7701 | |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0674 | 0.1874 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0357 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.1765 | 0.5239 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0085 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0193 | 0.0169 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.005 | 0.0357 | 0.0334 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.1765 | 0.1746 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0085 | 0.0785 | 0.233 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0085 | 0.0785 | 0.2207 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.005 | 0.0357 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0193 | 0.0169 |
Echinococcus granulosus | acetylcholinesterase | 0.0295 | 0.3369 | 0.3354 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0193 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0357 | 0.0915 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0193 | 0.0571 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.005 | 0.0357 | 0.0334 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0193 | 0.5 |
Echinococcus granulosus | neuroligin | 0.005 | 0.0357 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0785 | 0.233 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.1765 | 0.1746 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1518 | 0.4506 |
Brugia malayi | Carboxylesterase family protein | 0.0295 | 0.3369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0085 | 0.0785 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.3369 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1518 | 0.4418 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.1484 | 0.1484 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0357 | 0.0915 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.005 | 0.0357 | 0.0357 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0193 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0295 | 0.3369 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0357 | 0.0357 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0193 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0357 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Echinococcus multilocularis | acetylcholinesterase | 0.0295 | 0.3369 | 0.3354 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0357 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0295 | 0.3369 | 0.3354 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.1765 | 0.5163 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1518 | 0.4506 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.022 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0621 | 0.1844 |
Schistosoma mansoni | acetylcholinesterase | 0.005 | 0.0357 | 0.0357 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0357 | 0.0357 |
Echinococcus granulosus | BC026374 protein S09 family | 0.005 | 0.0357 | 0.0334 |
Echinococcus granulosus | acetylcholinesterase | 0.0295 | 0.3369 | 0.3354 |
Loa Loa (eye worm) | carboxylesterase | 0.0295 | 0.3369 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0085 | 0.0785 | 0.233 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.005 | 0.0357 | 0.0334 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0193 | 0.0193 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.005 | 0.0357 | 1 |
Echinococcus multilocularis | neuroligin | 0.005 | 0.0357 | 0.0334 |
Onchocerca volvulus | 0.0095 | 0.0913 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0273 | 0.0811 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.1484 | 0.1484 |
Echinococcus granulosus | carboxylesterase 5A | 0.0295 | 0.3369 | 0.3354 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0085 | 0.0785 | 0.0785 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.1765 | 0.1746 |
Loa Loa (eye worm) | serotonin transporter b | 0.0085 | 0.0785 | 0.233 |
Echinococcus multilocularis | acetylcholinesterase | 0.0295 | 0.3369 | 0.3354 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.0529 | 0.0529 |
Brugia malayi | hypothetical protein | 0.005 | 0.0357 | 0.0915 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0785 | 0.233 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0357 | 0.1058 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0357 | 0.0915 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0249 | 0.074 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.005 | 0.0357 | 0.0334 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0219 | 0.0501 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.