Detailed information for compound 781828

Basic information

Technical information
  • TDR Targets ID: 781828
  • Name: 4-[[(4-acetamidophenyl)sulfonylamino]methyl]- N-[(4-methoxyphenyl)methyl]benzamide
  • MW: 467.537 | Formula: C24H25N3O5S
  • H donors: 3 H acceptors: 4 LogP: 2.3 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)c1ccc(cc1)CNS(=O)(=O)c1ccc(cc1)NC(=O)C
  • InChi: 1S/C24H25N3O5S/c1-17(28)27-21-9-13-23(14-10-21)33(30,31)26-16-19-3-7-20(8-4-19)24(29)25-15-18-5-11-22(32-2)12-6-18/h3-14,26H,15-16H2,1-2H3,(H,25,29)(H,27,28)
  • InChiKey: CSQFNCXHQCAMHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[(4-acetamidophenyl)sulfonylamino]methyl]-N-(4-methoxybenzyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1344 0.1344
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0123 0.5
Schistosoma mansoni hypothetical protein 0.0317 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0026 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1344 0.1344
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1344 0.1344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0942 0.2133
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0123
Trichomonas vaginalis spcc417.12 protein, putative 0.0026 0 0.5
Echinococcus granulosus geminin 0.0182 0.5358 0.5358
Schistosoma mansoni hypothetical protein 0.0037 0.036 0.036
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1344 0.1344
Loa Loa (eye worm) acetylcholinesterase 1 0.0155 0.4418 0.4418
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1344 0.1344
Brugia malayi RNA, U transporter 1 0.0085 0.2005 0.4538
Mycobacterium tuberculosis Carboxylesterase LipT 0.0026 0 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0123 0.5
Brugia malayi Carboxylesterase family protein 0.0155 0.4418 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.036 0.036
Echinococcus multilocularis geminin 0.0182 0.5358 0.5358
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1344 0.3043
Onchocerca volvulus 0.0026 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0155 0.4418 0.4418
Loa Loa (eye worm) carboxylesterase 0.0155 0.4418 0.4418
Echinococcus granulosus tar DNA binding protein 0.0065 0.1344 0.1344
Brugia malayi Importin beta-1 subunit 0.003 0.0123 0.0277
Onchocerca volvulus 0.0026 0 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0155 0.4418 0.4418
Onchocerca volvulus 0.0026 0 0.5
Schistosoma mansoni importin beta-1 0.003 0.0123 0.0123
Brugia malayi RNA binding protein 0.0065 0.1344 0.3043
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1344 0.1344
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1344 0.1344
Echinococcus multilocularis acetylcholinesterase 0.0155 0.4418 0.4418
Brugia malayi TAR-binding protein 0.0065 0.1344 0.3043
Echinococcus granulosus acetylcholinesterase 0.0155 0.4418 0.4418
Loa Loa (eye worm) hypothetical protein 0.0054 0.0942 0.0942
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0942 0.2133
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0123 0.5
Echinococcus granulosus acetylcholinesterase 0.0155 0.4418 0.4418
Onchocerca volvulus 0.0026 0 0.5
Echinococcus granulosus importin subunit beta 1 0.003 0.0123 0.0123
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0 0.5
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0155 0.4418 0.4418
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.036 0.0815
Echinococcus multilocularis importin subunit beta 1 0.003 0.0123 0.0123
Plasmodium vivax importin-beta 2, putative 0.003 0.0123 0.5
Brugia malayi Carboxylesterase family protein 0.0155 0.4418 1
Plasmodium falciparum importin beta, putative 0.003 0.0123 0.5
Echinococcus multilocularis acetylcholinesterase 0.0155 0.4418 0.4418
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0026 0 0.5
Schistosoma mansoni hypothetical protein 0.0182 0.5358 0.5358
Loa Loa (eye worm) hypothetical protein 0.0155 0.4418 0.4418
Schistosoma mansoni hypothetical protein 0.0182 0.5358 0.5358
Echinococcus granulosus carboxylesterase 5A 0.0155 0.4418 0.4418
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0942 0.0942
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1344 0.1344
Echinococcus multilocularis snurportin 1 0.0317 1 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.1344 0.1344
Onchocerca volvulus 0.0026 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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