Detailed information for compound 781923

Basic information

Technical information
  • TDR Targets ID: 781923
  • Name: ethyl 4-[4-(3,4-dimethoxyphenyl)-6-oxo-3-phen yl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benz oate
  • MW: 483.515 | Formula: C28H25N3O5
  • H donors: 1 H acceptors: 3 LogP: 3.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)N1C(c2ccc(c(c2)OC)OC)c2c(C1=O)[nH]nc2c1ccccc1
  • InChi: 1S/C28H25N3O5/c1-4-36-28(33)18-10-13-20(14-11-18)31-26(19-12-15-21(34-2)22(16-19)35-3)23-24(17-8-6-5-7-9-17)29-30-25(23)27(31)32/h5-16,26H,4H2,1-3H3,(H,29,30)
  • InChiKey: PGSBRKOTLKCQEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-(3,4-dimethoxyphenyl)-6-oxo-3-phenyl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid ethyl ester
  • 4-[4-(3,4-dimethoxyphenyl)-6-keto-3-phenyl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1884 0.1849
Echinococcus granulosus intermediate filament protein 0.0028 0.0205 0.0198
Schistosoma mansoni memapsin-2 (A01 family) 0.0472 0.6372 0.6357
Loa Loa (eye worm) acetylcholinesterase 1 0.0395 0.5297 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0334 0.2242
Echinococcus multilocularis Smad4 0.0017 0.0058 0.0051
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.009 0.0228
Schistosoma mansoni cpg binding protein 0.0063 0.069 0.0649
Echinococcus multilocularis GPCR, family 2 0.0065 0.073 0.0723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1884 0.1878
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0283 0.1776
Brugia malayi Latrophilin receptor protein 2 0.0065 0.073 0.1333
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0731 0.0691
Onchocerca volvulus 0.0037 0.0334 0.0599
Echinococcus granulosus acetylcholinesterase 0.0395 0.5297 0.5293
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0747 0.0707
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0643 0.1215
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0334 0.0327
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0094 0.0087
Onchocerca volvulus 0.0067 0.0747 0.1596
Brugia malayi CXXC zinc finger family protein 0.0059 0.0643 0.1169
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0318 0.4232 0.799
Loa Loa (eye worm) hypothetical protein 0.0027 0.0198 0.0374
Mycobacterium tuberculosis Conserved protein 0.0037 0.0334 0.0811
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1884 0.1878
Brugia malayi beta-lactamase 0.0037 0.0334 0.0581
Echinococcus multilocularis para nitrobenzyl esterase 0.0067 0.0747 0.0741
Echinococcus multilocularis muscleblind protein 0.0171 0.2197 0.2191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0205 0.0388
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0027 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0283 0.0276
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0058 0.0109
Echinococcus granulosus para nitrobenzyl esterase 0.0067 0.0747 0.0741
Echinococcus granulosus GPCR family 2 0.0065 0.073 0.0723
Mycobacterium leprae Probable lipase LipE 0.0037 0.0334 0.5
Loa Loa (eye worm) hypothetical protein 0.0141 0.1783 0.3366
Echinococcus granulosus dnaJ subfamily B 0.0423 0.5686 0.5683
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1176 0.2631
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0334 0.0811
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Onchocerca volvulus 0.0028 0.0205 0.029
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1176 0.117
Loa Loa (eye worm) hypothetical protein 0.0171 0.2197 0.4147
Brugia malayi intermediate filament protein 0.0028 0.0205 0.0338
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0747 0.0707
Loa Loa (eye worm) carboxylesterase 0.0067 0.0747 0.141
Loa Loa (eye worm) aspartyl protease 6 0.0019 0.0085 0.0161
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0283 0.1776
Echinococcus granulosus geminin 0.0523 0.7073 0.7071
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0334 0.0811
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.3279 0.6191
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0067 0.0747 0.0741
Schistosoma mansoni smad1 5 8 and 0.0017 0.0058 0.0014
Echinococcus granulosus Smad4 0.0017 0.0058 0.0051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.1884 0.3557
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.009 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0205 0.0388
Onchocerca volvulus 0.0037 0.0334 0.0599
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1176 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0731 0.5902
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0279 0.0272
Onchocerca volvulus 0.0059 0.0643 0.1346
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0019 0.0085 0.0078
Schistosoma mansoni hypothetical protein 0.005 0.0514 0.0472
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1176 0.2221
Schistosoma mansoni smad1 5 8 and 0.0017 0.0058 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.2691 0.5054
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0731 0.2136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0283 0.0276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0334 0.0291
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.3212 0.3207
Schistosoma mansoni BC026374 protein (S09 family) 0.0067 0.0747 0.0707
Schistosoma mansoni ap endonuclease 0.0019 0.009 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0756 0.0716
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0756 0.0716
Brugia malayi MH2 domain containing protein 0.0017 0.0058 0.0057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.073 0.0723
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0283 0.1511
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0334 0.0905
Loa Loa (eye worm) carboxylesterase 0.0395 0.5297 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0315 0.0594
Schistosoma mansoni hypothetical protein 0.0065 0.073 0.0689
Brugia malayi Carboxylesterase family protein 0.0395 0.5297 1
Onchocerca volvulus 0.0273 0.3606 0.849
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1176 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0334 0.0327
Echinococcus multilocularis cpg binding protein 0.0063 0.069 0.0684
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0085 0.0042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0334 0.3706
Brugia malayi aspartic protease BmAsp-1, identical 0.0019 0.0085 0.011
Brugia malayi Carboxylesterase family protein 0.0395 0.5297 1
Leishmania major hypothetical protein, conserved 0.0037 0.0334 0.2242
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.1884 0.3524
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0731 0.9758
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0334 0.063
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0315 0.1751
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Echinococcus multilocularis geminin 0.0523 0.7073 0.7071
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0058 0.0051
Echinococcus granulosus BC026374 protein S09 family 0.0067 0.0747 0.0741
Trichomonas vaginalis spcc417.12 protein, putative 0.0067 0.0747 0.2054
Loa Loa (eye worm) RNA binding protein 0.0067 0.0756 0.1428
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.009 0.5
Echinococcus multilocularis musashi 0.0028 0.0205 0.0198
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.073 0.1333
Echinococcus granulosus cpg binding protein 0.0063 0.069 0.0684
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0283 0.0643
Mycobacterium tuberculosis Conserved protein 0.0037 0.0334 0.0811
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0756 0.075
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0756 0.0716
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.3212 0.3207
Brugia malayi Pre-SET motif family protein 0.024 0.3149 0.5923
Loa Loa (eye worm) histone methyltransferase 0.002 0.0094 0.0177
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1176 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0058 0.0014
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Echinococcus granulosus lamin dm0 0.0028 0.0205 0.0198
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.1396 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.009 0.012
Brugia malayi Carboxylesterase family protein 0.0067 0.0747 0.1366
Mycobacterium ulcerans carboxylesterase, LipT 0.0067 0.0747 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Brugia malayi MH2 domain containing protein 0.0249 0.3279 0.6172
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0085 0.0042
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0044 0.0037
Mycobacterium ulcerans beta-lactamase 0.0037 0.0334 0.3706
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0334 0.0905
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.063
Schistosoma mansoni cpg binding protein 0.0059 0.0643 0.0602
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.009 0.0083
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Brugia malayi RNA binding protein 0.0067 0.0756 0.1383
Schistosoma mansoni hypothetical protein 0.0523 0.7073 0.706
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0492 0.1346
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0058 0.0014
Schistosoma mansoni kinase 0.005 0.051 0.0469
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.063
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Echinococcus granulosus lamin 0.0028 0.0205 0.0198
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0315 0.0308
Toxoplasma gondii exonuclease III APE 0.0019 0.009 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0273 0.3606 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0334 0.0811
Schistosoma mansoni intermediate filament proteins 0.0028 0.0205 0.0162
Onchocerca volvulus 0.0037 0.0334 0.0599
Brugia malayi hypothetical protein 0.0067 0.0747 0.1366
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.063
Loa Loa (eye worm) hypothetical protein 0.0244 0.3212 0.6064
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0283 0.0241
Echinococcus granulosus tar DNA binding protein 0.0067 0.0756 0.075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Schistosoma mansoni survival motor neuron protein 0.005 0.0514 0.0472
Brugia malayi TAR-binding protein 0.0067 0.0756 0.1383
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1176 0.1138
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0019 0.0085 0.0161
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.3279 0.6191
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0067 0.0747 0.0741
Brugia malayi Carboxylesterase family protein 0.0067 0.0747 0.1366
Loa Loa (eye worm) hypothetical protein 0.0395 0.5297 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0334 0.063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0334 0.0905
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0283 0.1776
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0044 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.009 0.0228
Schistosoma mansoni ap endonuclease 0.0019 0.009 0.0047
Echinococcus multilocularis neuroligin 0.0067 0.0747 0.0741
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0334 0.0811
Brugia malayi Pepsin A precursor 0.0019 0.0085 0.011
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0756 0.1428
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0283 0.0276
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0019 0.0085 0.0078
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0731 0.0725
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0283 0.0485
Echinococcus multilocularis microtubule associated protein 2 0.0734 1 1
Loa Loa (eye worm) carboxylesterase 0.0067 0.0747 0.141
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0334 0.5
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0283 0.1776
Brugia malayi MH2 domain containing protein 0.0017 0.0058 0.0057
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0058 0.0051
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0283 0.1511
Echinococcus multilocularis acetylcholinesterase 0.0395 0.5297 0.5293
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0334 0.2242
Schistosoma mansoni microtubule-associated protein tau 0.0734 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.1783 0.3332
Toxoplasma gondii ABC1 family protein 0.0037 0.0334 0.1897
Schistosoma mansoni acetylcholinesterase 0.0067 0.0747 0.0707
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0334 0.2242
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0731 0.0691
Mycobacterium ulcerans hypothetical protein 0.0037 0.0334 0.3706
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1176 0.117
Loa Loa (eye worm) hypothetical protein 0.0171 0.2197 0.4147
Loa Loa (eye worm) hypothetical protein 0.0395 0.5297 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0283 0.1776
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1176 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0058 0.0051
Onchocerca volvulus 0.0318 0.4232 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0315 0.0308
Echinococcus multilocularis smad 0.0017 0.0058 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0315 0.0272
Echinococcus multilocularis lamin dm0 0.0028 0.0205 0.0198
Onchocerca volvulus 0.0028 0.0205 0.029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.073 0.1378
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0161
Brugia malayi beta-lactamase family protein 0.0037 0.0334 0.0581
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0756 0.0716
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0019 0.0085 0.0214
Brugia malayi Carboxylesterase family protein 0.0067 0.0747 0.1366
Echinococcus multilocularis carboxylesterase 5A 0.0395 0.5297 0.5293
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0731 0.0725
Echinococcus granulosus acetylcholinesterase 0.0395 0.5297 0.5293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0334 0.0291
Brugia malayi MH1 domain containing protein 0.0017 0.0058 0.0057
Trypanosoma brucei polo-like protein kinase 0.0098 0.1176 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.3091 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0161
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Echinococcus multilocularis muscleblind protein 1 0.0171 0.2197 0.2191
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0315 0.0272
Giardia lamblia Kinase, PLK 0.0098 0.1176 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Onchocerca volvulus 0.0067 0.0747 0.1596
Brugia malayi Pre-SET motif family protein 0.0036 0.0315 0.0545
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0283 0.0276
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0094 0.0087
Schistosoma mansoni lamin 0.0028 0.0205 0.0162
Brugia malayi Muscleblind-like protein 0.0171 0.2197 0.4117
Schistosoma mansoni hypothetical protein 0.0423 0.5686 0.5667
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0058 0.0051
Schistosoma mansoni hypothetical protein 0.0065 0.073 0.0689
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.073 0.0723
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0013
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.5686 0.5683
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0067 0.0747 0.2054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Brugia malayi beta-lactamase family protein 0.0037 0.0334 0.0581
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0161
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.063
Brugia malayi hypothetical protein 0.0019 0.0085 0.011
Mycobacterium ulcerans lipase LipD 0.0037 0.0334 0.3706
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0731 0.9758
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0067 0.0747 0.2189
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0334 0.0905
Schistosoma mansoni neuroligin 3 (S09 family) 0.0067 0.0747 0.0707
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0334 0.0811
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0067 0.0747 0.2189
Schistosoma mansoni Smad4 0.0017 0.0058 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0731 0.9758
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0283 0.0276
Echinococcus granulosus neuroligin 0.0067 0.0747 0.0741
Onchocerca volvulus 0.0067 0.0747 0.1596
Brugia malayi aspartic protease BmAsp-2, identical 0.0019 0.0085 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.009 0.0083
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0747 0.0707
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0492 0.1346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1884 0.1878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1884 0.1849
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0334 0.0811
Brugia malayi hypothetical protein 0.0318 0.4232 0.7979
Echinococcus granulosus smad 0.0017 0.0058 0.0051
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0283 0.0535
Schistosoma mansoni gliotactin 0.0067 0.0747 0.0707
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.009 0.0208
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.073 0.0723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1884 0.1849
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0334 0.0811
Onchocerca volvulus 0.0067 0.0747 0.1596
Brugia malayi isocitrate dehydrogenase 0.0033 0.0283 0.0485
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0044 0.0037
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0283 0.0276
Echinococcus multilocularis lamin 0.0028 0.0205 0.0198
Schistosoma mansoni lamin 0.0028 0.0205 0.0162
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0514 0.0923
Trichomonas vaginalis esterase, putative 0.0037 0.0334 0.0905
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0334 0.3706
Brugia malayi hypothetical protein 0.0244 0.3212 0.6044
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.063
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0395 0.5297 0.5276
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.2691 0.508
Schistosoma mansoni cpg binding protein 0.0063 0.069 0.0649
Schistosoma mansoni hypothetical protein 0.0523 0.7073 0.706
Echinococcus multilocularis acetylcholinesterase 0.0395 0.5297 0.5293
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0334 0.0811
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Schistosoma mansoni hypothetical protein 0.0141 0.1783 0.1747
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0205 0.0388
Loa Loa (eye worm) hypothetical protein 0.0065 0.073 0.1378
Mycobacterium tuberculosis Carboxylesterase LipT 0.0067 0.0747 0.2189
Loa Loa (eye worm) hypothetical protein 0.0207 0.2691 0.508
Onchocerca volvulus 0.005 0.0514 0.1033
Brugia malayi hypothetical protein 0.0019 0.0085 0.011
Echinococcus granulosus carboxylesterase 5A 0.0395 0.5297 0.5293
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.009 0.0261
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1884 0.1878
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0756 0.1428
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1176 0.3247
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0283 0.7965
Brugia malayi Eukaryotic aspartyl protease family protein 0.0019 0.0085 0.011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.073 0.0723
Onchocerca volvulus 0.0067 0.0747 0.1596
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.009 0.0119
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1176 0.218
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0058 0.0109
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0019 0.0085 0.0161
Onchocerca volvulus 0.0036 0.0315 0.0553
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0756 0.0716
Loa Loa (eye worm) Smad1 0.0017 0.0058 0.0109
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0315 0.0272
Brugia malayi Smad1 0.0017 0.0058 0.0057
Schistosoma mansoni hypothetical protein 0.0065 0.073 0.0689
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0756 0.1383
Loa Loa (eye worm) hypothetical protein 0.0037 0.0334 0.063
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0283 1
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0731 0.493
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1582 0.1545
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0334 0.0581
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.2691 0.5054
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0334 0.0905
Schistosoma mansoni hypothetical protein 0.0065 0.073 0.0689
Schistosoma mansoni smad 0.0017 0.0058 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0315 0.0272
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0205 0.0338
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.009 0.017
Echinococcus multilocularis BC026374 protein (S09 family) 0.0067 0.0747 0.0741
Plasmodium vivax SET domain protein, putative 0.0036 0.0315 0.9229
Echinococcus granulosus muscleblind protein 0.0171 0.2197 0.2191
Brugia malayi Carboxylesterase family protein 0.0067 0.0747 0.1366
Brugia malayi MH1 domain containing protein 0.0017 0.0058 0.0057
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0085 0.0042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0747 0.141
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.3149 0.5944
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0315 0.0308

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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