TDR Targets

Basic information

Technical information

TDR Targets ID: 781956
Name: N-[3-(butyl-methylamino)propyl]-2-[(3-methyls ulfanylphenyl)amino]quinoline-4-carboxamide
MW: 436.613 | Formula: C25H32N4OS
H donors: 2 H acceptors: 2 LogP: 5.5 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(CCCNC(=O)c1cc(Nc2cccc(c2)SC)nc2c1cccc2)C
InChi: 1S/C25H32N4OS/c1-4-5-15-29(2)16-9-14-26-25(30)22-18-24(28-23-13-7-6-12-21(22)23)27-19-10-8-11-20(17-19)31-3/h6-8,10-13,17-18H,4-5,9,14-16H2,1-3H3,(H,26,30)(H,27,28)
InChiKey: PGWWDRDQDKWQDZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-(butyl-methyl-amino)propyl]-2-[(3-methylsulfanylphenyl)amino]quinoline-4-carboxamide
N-[3-(butyl-methylamino)propyl]-2-[[3-(methylthio)phenyl]amino]-4-quinolinecarboxamide
N-[3-(butyl-methyl-amino)propyl]-2-[[3-(methylthio)phenyl]amino]cinchoninamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Echinococcus multilocularis	neural cadherin	0.0541	0.2108	0.2108
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0174	0.6582
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.001	0.0948
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0164	0.9406
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0012	0.0012
Leishmania major	cathepsin L-like protease	0.0077	0.0265	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Echinococcus granulosus	notch	0.0541	0.2108	0.2108
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0164	0.0164
Echinococcus multilocularis	notch	0.0541	0.2108	0.2108
Brugia malayi	Calcium binding EGF domain containing protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Brugia malayi	glutathione reductase	0.0037	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0019	0.0034	0.0034
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0164	0.9406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0039	0.2236
Brugia malayi	Animal haem peroxidase family protein	0.2526	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4297
Leishmania major	cathepsin L-like protease	0.0077	0.0265	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4307
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0541	0.2108	0.2108
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.001	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.0164	0.6039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0012	0.0711
Giardia lamblia	High cysteine protein	0.0541	0.2108	1
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Echinococcus granulosus	slit 2 protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0174	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.0031	0.0815
Schistosoma mansoni	hypothetical protein	0.0041	0.0122	0.0122
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0031	0.1168
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.0336	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0039	0.0039
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.0298	0.8837
Echinococcus granulosus	neural cadherin	0.0541	0.2108	0.2108
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.0164	0.6039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0016	0.0945
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.001	0.001
Onchocerca volvulus	Peroxidase homolog	0.2526	1	1
Echinococcus multilocularis	peroxidasin	0.2526	1	1
Echinococcus granulosus	protein jagged 2	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0087	0.5019
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0107	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.0164	0.6191
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.001	0.5
Brugia malayi	Calcium binding EGF domain containing protein	0.0541	0.2108	0.2108
Echinococcus granulosus	neurogenic locus notch protein	0.0541	0.2108	0.2108
Leishmania major	cathepsin L-like protease	0.002	0.0039	0.113
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.001	0.001
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.0298	0.8837
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0143	0.0143
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.001	0.0385
Onchocerca volvulus	Peroxidase homolog	0.2526	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0039	0.0036
Echinococcus granulosus	protein jagged 2	0.0541	0.2108	0.2108
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0034	0.0034
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0532	0.0529
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.3271	0.3271
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Echinococcus multilocularis	slit 2 protein	0.0541	0.2108	0.2108
Echinococcus granulosus	cathepsin l1	0.002	0.0039	0.0039
Plasmodium falciparum	glutathione reductase	0.0037	0.0107	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0039	0.0039
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0031	0.0031
Echinococcus multilocularis	protein jagged 1	0.0541	0.2108	0.2108
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0031	0.0031
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.0336	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0198	0.0195
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0107	0.0492
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Toxoplasma gondii	cathepsin CPL	0.002	0.0039	0.0166
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0039	0.0027
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.001	0.0948
Brugia malayi	Blistered cuticle protein 3	0.2526	1	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0541	0.2108	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0012	0.0711
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0034	0.0034
Entamoeba histolytica	cysteine protease, putative	0.002	0.0039	0.2236
Brugia malayi	Calcium binding EGF domain containing protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0031	0.1775
Brugia malayi	Cathepsin L-like precursor	0.002	0.0039	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.013	0.7468
Onchocerca volvulus		0.2526	1	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.0164	0.0161
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.001	0.0029
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.001	0.001
Brugia malayi	Delta serrate ligand family protein	0.0541	0.2108	0.2108
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.0031	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0107	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Trypanosoma brucei	trypanothione reductase	0.0037	0.0107	0.4059
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Schistosoma mansoni	peroxidasin	0.2526	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0238	0.8997
Leishmania major	cathepsin L-like protease	0.002	0.0039	0.113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.006	0.0196	0.0193
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0541	0.2108	0.2108
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0014	0.0012	0.0012
Echinococcus granulosus	cathepsin l1	0.0014	0.0012	0.0012
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0198	0.0198
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0196	0.0196
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Loa Loa (eye worm)	fibroinase	0.002	0.0039	0.0036
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0174	1
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Echinococcus multilocularis	cysteine protease	0.002	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Schistosoma mansoni	notch	0.0541	0.2108	0.2108
Echinococcus granulosus	neurogenic locus notch protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0086	0.4946
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4297
Echinococcus multilocularis	neurogenic locus notch protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4297
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Echinococcus granulosus	delta-like protein 1	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.013	0.7468
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.001	0.0029
Brugia malayi	notch-like transmembrane receptor	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0143	0.819
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.2526	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0107	0.4059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Mycobacterium tuberculosis	Probable reductase	0.0085	0.0298	0.8837
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0039	0.0039
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.001	0.0585
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.001	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0039	0.0039
Onchocerca volvulus	Neurogenic locus notch homolog	0.0541	0.2108	0.2098
Echinococcus multilocularis	protein jagged 2	0.0541	0.2108	0.2108
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.0164	0.0164
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Echinococcus granulosus	tumor protein p63	0.0408	0.158	0.158
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0174	0.0172
Onchocerca volvulus		0.2526	1	1
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.001
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0039	0.1472
Giardia lamblia	GTOR	0.0054	0.0174	0.0782
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0039	0.0039
Loa Loa (eye worm)	animal heme peroxidase	0.2526	1	1
Brugia malayi	Animal haem peroxidase family protein	0.2526	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0174	0.6582
Echinococcus granulosus	protein jagged 1	0.0541	0.2108	0.2108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0014	0.0012	0.0012
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.001	0.5
Schistosoma mansoni	peroxidasin	0.2526	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0143	0.0143
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.0265	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0039	0.0039
Brugia malayi	Animal haem peroxidase family protein	0.2526	1	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.001	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0031	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.0164	0.0733
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0039	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0039	0.0036
Echinococcus multilocularis	tumor protein p63	0.0408	0.158	0.158
Onchocerca volvulus		0.002	0.0039	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0174	0.6582
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Leishmania major	cathepsin L-like protease	0.002	0.0039	0.113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Loa Loa (eye worm)	ctsf protein	0.002	0.0039	0.0036
Brugia malayi	MAP kinase sur-1	0.0052	0.0164	0.0164
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0174	0.0174
Loa Loa (eye worm)	cysteine protease	0.002	0.0039	0.0036
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0012	0.0012
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.001	0.0385
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.001	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Brugia malayi	Animal haem peroxidase family protein	0.2526	1	1
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Onchocerca volvulus		0.0541	0.2108	0.2098
Schistosoma mansoni	notch	0.0541	0.2108	0.2108
Brugia malayi	cathepsin L-like precursor	0.0014	0.0012	0.0012
Echinococcus multilocularis	protein jagged 1	0.0541	0.2108	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0034	0.0032
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0039	0.0036
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0541	0.2108	0.2098
Onchocerca volvulus		0.002	0.0039	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0107	0.2985
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Loa Loa (eye worm)	hypothetical protein	0.006	0.0198	0.0195
Loa Loa (eye worm)	animal heme peroxidase	0.2526	1	1
Onchocerca volvulus		0.0541	0.2108	0.2098
Brugia malayi	Thioredoxin reductase	0.0037	0.0107	0.0107
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0174	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0031	0.0031
Onchocerca volvulus	Peroxidasin homolog	0.2526	1	1
Onchocerca volvulus		0.006	0.0196	0.0184
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0099	0.5658
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0143	0.0143
Brugia malayi	Cathepsin L-like precursor	0.002	0.0039	0.0039
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0039	0.0027
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.001	0.0385
Onchocerca volvulus		0.002	0.0039	0.0027
Brugia malayi	Cathepsin L-like precursor	0.002	0.0039	0.0039
Schistosoma mansoni	slit	0.0541	0.2108	0.2108
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.001	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.0164	0.6191
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Loa Loa (eye worm)	notch protein	0.0541	0.2108	0.2106
Onchocerca volvulus		0.002	0.0039	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.0164	0.0164
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.001	0.0385
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0143	0.014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0039	0.2236
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.0298	0.8837
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0107	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4307
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.001
Brugia malayi	Animal haem peroxidase family protein	0.2526	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.013	0.7468
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0031	0.1775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Echinococcus granulosus	neurogenic locus protein delta	0.0541	0.2108	0.2108
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0039	0.113
Brugia malayi	Cathepsin L-like precursor	0.002	0.0039	0.0039
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0034	0.0034
Loa Loa (eye worm)	animal heme peroxidase	0.2526	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0122	0.012
Brugia malayi	MH2 domain containing protein	0.0144	0.0532	0.0532
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0164	0.9406
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0174	0.6446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0031	0.1775
Schistosoma mansoni	notch	0.0541	0.2108	0.2108
Echinococcus multilocularis	neurogenic locus notch protein	0.0541	0.2108	0.2108
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.001	0.0585
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Onchocerca volvulus	Dual oxidase homolog	0.2526	1	1
Brugia malayi	Cadherin domain containing protein	0.0541	0.2108	0.2108
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0143	0.0143
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.001	0.0385
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.001	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0034	0.0032
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0012	0.0711
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0034	0.0034
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.001	0.0385
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0199	0.7525
Schistosoma mansoni	notch	0.0541	0.2108	0.2108
Schistosoma mansoni	notch	0.0541	0.2108	0.2108
Echinococcus granulosus	protein jagged 1	0.0541	0.2108	0.2108
Echinococcus multilocularis	cysteine protease	0.002	0.0039	0.0039
Onchocerca volvulus		0.0541	0.2108	0.2098
Plasmodium falciparum	glutathione reductase	0.0013	0.001	0.0948
Schistosoma mansoni	hypothetical protein	0.0019	0.0034	0.0034
Schistosoma mansoni	septate junction protein	0.0541	0.2108	0.2108
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.001	0.0385
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0061	0.2289
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.001	0.0385
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0164	0.6191
Schistosoma mansoni	notch	0.0541	0.2108	0.2108
Plasmodium vivax	vivapain-2	0.002	0.0039	0.3625
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Onchocerca volvulus	Slit protein homolog	0.0541	0.2108	0.2098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0031	0.1775
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.0164	0.0164
Brugia malayi	GCC2 and GCC3 family protein	0.0541	0.2108	0.2108
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0039	0.0039
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0174	0.6582
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0532	0.0529
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0039	0.0027
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.001	0.0948
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0174	0.6446
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0164	0.9406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.0298	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0541	0.2108	0.2108
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4307
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0086	0.4946
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.001	0.0385
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0031	0.1168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0143	0.0143
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0119	0.0546
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0034	0.0034
Schistosoma mansoni	hypothetical protein	0.0019	0.0034	0.0034
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0143	0.0143
Schistosoma mansoni	laminin gamma-3 chain	0.0541	0.2108	0.2108
Echinococcus multilocularis	neurogenic locus protein delta	0.0541	0.2108	0.2108
Echinococcus multilocularis	neurogenic locus protein delta	0.0541	0.2108	0.2108
Toxoplasma gondii	EGF family domain-containing protein	0.0541	0.2108	1
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Onchocerca volvulus		0.002	0.0039	0.0027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0265	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Schistosoma mansoni	hypothetical protein	0.0019	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0265	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0075	0.4307
Onchocerca volvulus		0.2526	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0048	0.182
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.3271	0.3271
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.001	0.0385
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.0336	1
Brugia malayi	Muscle positioning protein 4	0.0541	0.2108	0.2108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0103	0.5926
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0004	0.0002
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.0164	0.6191
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0031	0.1168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0039	0.0039
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0164	0.6191
Onchocerca volvulus	Peroxidasin homolog	0.2526	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0265	1
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.3271	0.3271
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0174	0.0174
Onchocerca volvulus	Chorion peroxidase homolog	0.2526	1	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.2526	1	1
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0174	0.0174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0174	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0087	0.5019
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0107	0.0105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0265	1
Leishmania major	trypanothione reductase	0.0037	0.0107	0.3821
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0039	0.3625
Brugia malayi	Cadherin domain containing protein	0.0541	0.2108	0.2108
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.0164	0.076
Leishmania major	cathepsin L-like protease	0.002	0.0039	0.113
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0109	0.0109
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.001	0.0385
Echinococcus multilocularis	fibropellin Ia	0.0541	0.2108	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.0298	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Leishmania major	cathepsin L-like protease	0.002	0.0039	0.113
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0039	0.2236
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.013	0.4922
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Plasmodium falciparum	thioredoxin reductase	0.0013	0.001	0.0948
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0174	0.0174
Brugia malayi	Peroxidasin	0.2526	1	1
Loa Loa (eye worm)	hypothetical protein	0.2526	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0039	0.2236
Echinococcus granulosus	GPCR family 2	0.0019	0.0034	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.013	0.7468
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Onchocerca volvulus	Putative cubilin	0.0541	0.2108	0.2098
Onchocerca volvulus		0.0541	0.2108	0.2098
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0031	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0039	0.3625
Treponema pallidum	NADH oxidase	0.0013	0.001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.013	0.7468
Schistosoma mansoni	cell polarity protein	0.0541	0.2108	0.2108
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0039	0.2236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0087	0.5019
Echinococcus granulosus	peroxidasin	0.2526	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0198	0.0198
Leishmania major	cathepsin L-like protease	0.0077	0.0265	1
Plasmodium vivax	vivapain-2	0.002	0.0039	0.3625
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0143	0.0143
Schistosoma mansoni	hypothetical protein	0.0541	0.2108	0.2108
Trypanosoma brucei	protein kinase, putative	0.0052	0.0164	0.6191
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0004	0.0233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0031	0.1775
Onchocerca volvulus		0.0541	0.2108	0.2098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0119	0.6829
Loa Loa (eye worm)	hypothetical protein	0.0541	0.2108	0.2106
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.0336	1
Loa Loa (eye worm)	Notch2	0.0541	0.2108	0.2106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0174	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0031	0.1168
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.013	0.4922
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0034	0.0034
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0039	0.2236
Onchocerca volvulus		0.002	0.0039	0.0027
Onchocerca volvulus		0.002	0.0039	0.0027
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.013	0.4719
Echinococcus granulosus	fibropellin Ia	0.0541	0.2108	0.2108
Echinococcus granulosus	neurogenic locus notch protein 4	0.0541	0.2108	0.2108
Brugia malayi	Cathepsin L-like precursor	0.002	0.0039	0.0039
Brugia malayi	EGF-like domain containing protein	0.0541	0.2108	0.2108
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0039	0.3625

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 781956