Detailed information for compound 782000

Basic information

Technical information
  • TDR Targets ID: 782000
  • Name: ethyl 4-[4-(4-methylphenyl)-6-oxo-3-phenyl-1, 4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoate
  • MW: 437.49 | Formula: C27H23N3O3
  • H donors: 1 H acceptors: 3 LogP: 4.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)N1C(c2ccc(cc2)C)c2c(C1=O)[nH]nc2c1ccccc1
  • InChi: 1S/C27H23N3O3/c1-3-33-27(32)20-13-15-21(16-14-20)30-25(19-11-9-17(2)10-12-19)22-23(18-7-5-4-6-8-18)28-29-24(22)26(30)31/h4-16,25H,3H2,1-2H3,(H,28,29)
  • InChiKey: WIEYAYBSUPBONT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-(4-methylphenyl)-6-oxo-3-phenyl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid ethyl ester
  • 4-[6-keto-4-(4-methylphenyl)-3-phenyl-1,4-dihydropyrrolo[4,3-d]pyrazol-5-yl]benzoic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0065 0.0181 0.1432
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.021 0.021
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Echinococcus multilocularis zinc finger protein 0.004 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.0792 0.0792
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0051 0.0104
Brugia malayi Carboxylesterase family protein 0.1387 0.4957 1
Onchocerca volvulus 0.0023 0.0028 0.0057
Echinococcus granulosus beta LACTamase domain containing family member 0.0143 0.0461 0.0461
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0569 0.4506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0093 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Schistosoma mansoni gliotactin 0.0234 0.0792 0.0792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Schistosoma mansoni hypothetical protein 0.0058 0.0156 0.0156
Brugia malayi beta-lactamase family protein 0.0143 0.0461 0.093
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0164 0.1302
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0143 0.0461 0.1237
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.0461 0.3649
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Echinococcus granulosus neuroligin 0.0234 0.0792 0.0792
Echinococcus granulosus BC026374 protein S09 family 0.0234 0.0792 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0519
Trypanosoma cruzi ISWI complex protein 0.0031 0.0058 0.0462
Brugia malayi Bromodomain containing protein 0.0153 0.0498 0.1004
Schistosoma mansoni hypothetical protein 0.0029 0.0051 0.0051
Echinococcus multilocularis tumor protein p63 0.0666 0.2351 0.2351
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Brugia malayi PHD-finger family protein 0.0029 0.0051 0.0104
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0019 0.0019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0553
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Toxoplasma gondii peptidylprolyl isomerase 0.0065 0.0181 0.3666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus multilocularis microtubule associated protein 2 0.2784 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0181 0.1432
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1263 1
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0461 0.3649
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0083 0.0083
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0553
Onchocerca volvulus 0.0234 0.0792 0.4903
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0028 0.0203
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0019 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0083 0.0083
Trichomonas vaginalis hypothetical protein 0.0023 0.0028 0.0346
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0131 0.1037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0067 0.0187 0.0376
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0461 0.3649
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0381 0.0768
Echinococcus granulosus cathepsin l1 0.002 0.0019 0.0019
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0065 0.0181 0.1432
Brugia malayi hypothetical protein 0.0234 0.0792 0.1599
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.012 0.6258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0531
Brugia malayi Protein cec-1. 0.0023 0.0028 0.0056
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0019 0.0019
Echinococcus multilocularis peregrin 0.0034 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni neuroligin 3 (S09 family) 0.0234 0.0792 0.0792
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0143 0.0461 0.093
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Brugia malayi Pre-SET motif family protein 0.003 0.0053 0.0107
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0022 0.0176
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Mycobacterium tuberculosis Conserved protein 0.0143 0.0461 0.1237
Leishmania major hypothetical protein, conserved 0.0031 0.0058 0.0462
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0234 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0131 0.1037
Leishmania major cathepsin L-like protease 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0075 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0108 0.1347
Brugia malayi AMP-binding enzyme family protein 0.0048 0.012 0.0242
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0019 0.0234
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.012 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.012 0.0952
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0028 0.0056
Trypanosoma brucei ISWI complex protein 0.0031 0.0058 0.0462
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0083 0.0168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0911 0.3237 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0227 0.2834
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.0792 0.0792
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0248 0.1452
Onchocerca volvulus 0.0048 0.012 0.0643
Echinococcus granulosus para nitrobenzyl esterase 0.0234 0.0792 0.0792
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0019 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0143 0.0461 0.1237
Brugia malayi hypothetical protein 0.0023 0.0028 0.0056
Trypanosoma cruzi ISWI complex protein 0.0031 0.0058 0.0462
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Echinococcus granulosus tumor protein p63 0.0666 0.2351 0.2351
Echinococcus multilocularis acetylcholinesterase 0.1387 0.4957 0.4957
Loa Loa (eye worm) hypothetical protein 0.0065 0.0179 0.0361
Loa Loa (eye worm) helicase 0.0023 0.0028 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0381 0.0768
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0051 0.0739
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0108 0.1347
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.0461 0.5767
Giardia lamblia GTOR 0.0045 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0108 0.0217
Onchocerca volvulus 0.0143 0.0461 0.2802
Onchocerca volvulus 0.0061 0.0166 0.0932
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.012 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0084 0.105
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0553
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0028 0.0056
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0019 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.0461 0.0461
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0145 0.1808
Echinococcus granulosus expressed protein 0.0067 0.0187 0.0187
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0298 0.0298
Brugia malayi beta-lactamase family protein 0.0143 0.0461 0.093
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0042 0.0042
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0569 0.4506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Onchocerca volvulus 0.0234 0.0792 0.4903
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1387 0.4957 0.4957
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Onchocerca volvulus 0.0143 0.0461 0.2802
Brugia malayi Heterochromatin protein 1 0.0139 0.0447 0.0901
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0143 0.0461 0.5372
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0108 0.0217
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0028 0.0203
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0179 0.0179
Schistosoma mansoni chromobox protein 0.0023 0.0028 0.0028
Loa Loa (eye worm) acetylcholinesterase 1 0.1387 0.4957 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0108 0.0852
Loa Loa (eye worm) carboxylesterase 0.0234 0.0792 0.1599
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0381 0.0768
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0243 0.049
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0098
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0181 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.026 0.0524
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0466 0.0941
Brugia malayi Bromodomain containing protein 0.0034 0.0069 0.0139
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0224 0.1773
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.064 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Brugia malayi SET domain containing protein 0.0024 0.0032 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0286 0.0977 0.1971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0108 0.0108
Mycobacterium tuberculosis Probable esterase LipL 0.0143 0.0461 0.1237
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Trichomonas vaginalis rotamase, putative 0.0065 0.0181 0.2263
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0028 0.0028
Onchocerca volvulus 0.0058 0.0156 0.087
Echinococcus granulosus Chromo domain 0.0023 0.0028 0.0028
Mycobacterium tuberculosis Conserved protein 0.0143 0.0461 0.1237
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0051 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0413
Brugia malayi Pre-SET motif family protein 0.0208 0.0696 0.1403
Loa Loa (eye worm) heterochromatin protein 1 0.0139 0.0447 0.0901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0977 0.0977
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0145 0.1808
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0108 0.0852
Mycobacterium tuberculosis Carboxylesterase LipT 0.0234 0.0792 0.2283
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.0077 0.0224 0.1773
Trichomonas vaginalis esterase, putative 0.0143 0.0461 0.5767
Echinococcus granulosus chromobox protein 1 0.0139 0.0447 0.0447
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0088 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.012 0.0952
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Echinococcus granulosus zinc finger protein 0.004 0.009 0.009
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0076 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.012 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.012 0.0162
Schistosoma mansoni microtubule-associated protein tau 0.2784 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0143 0.0461 0.1237
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0179 0.0179
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0028 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0088 0.0177
Echinococcus multilocularis beta LACTamase domain containing family member 0.0143 0.0461 0.0461
Mycobacterium ulcerans esterase/lipase LipP 0.0143 0.0461 0.5372
Onchocerca volvulus 0.0236 0.0799 0.4945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.012 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0028 0.0346
Mycobacterium leprae conserved hypothetical protein 0.0143 0.0461 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Schistosoma mansoni hypothetical protein 0.0082 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0082 0.0243 0.049
Mycobacterium ulcerans hypothetical protein 0.0192 0.064 0.7866
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0028 0.0028
Echinococcus granulosus acetylcholinesterase 0.1387 0.4957 0.4957
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1263 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0248 0.3101
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0019 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0696 0.1403
Echinococcus multilocularis carboxylesterase 5A 0.1387 0.4957 0.4957
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0067 0.0187 0.0376
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Echinococcus multilocularis acetylcholinesterase 0.1387 0.4957 0.4957
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0221 0.0221
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0224 0.1773
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0093 0.0093
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0013 0.0103
Onchocerca volvulus 0.0023 0.0028 0.0057
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0227 0.2834
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0019 0.0148
Echinococcus multilocularis cysteine protease 0.002 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0074 0.0932
Loa Loa (eye worm) hypothetical protein 0.1387 0.4957 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.0461 0.5767
Schistosoma mansoni survival motor neuron protein 0.0058 0.0156 0.0156
Echinococcus multilocularis chromobox protein 2 0.0023 0.0028 0.0028
Onchocerca volvulus 0.0143 0.0461 0.2802
Echinococcus multilocularis para nitrobenzyl esterase 0.0234 0.0792 0.0792
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0466 0.0941
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0108 0.0852
Loa Loa (eye worm) hypothetical protein 0.0144 0.0466 0.094
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0019 0.0019
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0075 0.0591
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0019 0.015
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.0461 0.5767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Echinococcus granulosus carboxylesterase 5A 0.1387 0.4957 0.4957
Brugia malayi jmjC domain containing protein 0.0096 0.0292 0.0589
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0292 0.0292
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0076 0.0153
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0385 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0242
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0131 0.1037
Mycobacterium leprae Probable lipase LipE 0.0143 0.0461 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0569 0.4506
Onchocerca volvulus 0.0052 0.0135 0.0738
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0051 0.0636
Echinococcus multilocularis neuroligin 0.0234 0.0792 0.0792
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0108 0.0852
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0108 0.0108
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0028 0.0056
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Echinococcus multilocularis Chromo domain 0.0023 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus multilocularis chromobox protein 1 0.0139 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Plasmodium vivax hypothetical protein, conserved 0.0143 0.0461 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0042 0.0084
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0051 0.0739
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.012 0.0616
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0346
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0028 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0179 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni bromodomain containing protein 0.0129 0.0411 0.0411
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0083 0.0168
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.012 0.6258
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0104
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0234 0.0792 0.9916
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0156 0.0315
Brugia malayi Carboxylesterase family protein 0.1387 0.4957 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0028 0.0056
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0447 0.5589
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Leishmania major cysteine peptidase A (CPA) 0.002 0.0019 0.0148
Brugia malayi jmjC domain containing protein 0.0039 0.0088 0.0177
Mycobacterium tuberculosis Conserved protein 0.0143 0.0461 0.1237
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0023 0.0028 0.0028
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.012 0.6258
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1263 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0019 0.0038
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0066 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0531
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0171 0.1357
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0292 0.0292
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0108 0.5483
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0112 0.0112
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0071 0.0071
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0076 0.5
Plasmodium vivax SET domain protein, putative 0.003 0.0053 0.0781
Brugia malayi CHD4 protein 0.0027 0.0042 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0048 0.012 0.0242
Schistosoma mansoni chromobox protein 0.0139 0.0447 0.0447
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0028 0.0346
Echinococcus multilocularis chromobox protein 1 0.0139 0.0447 0.0447
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.0461 0.5767
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.012 0.0616
Schistosoma mansoni zinc finger protein 0.004 0.009 0.009
Echinococcus multilocularis GPCR, family 2 0.0038 0.0083 0.0083
Echinococcus granulosus peregrin 0.0034 0.0069 0.0069
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0028 0.1563
Mycobacterium ulcerans hypothetical protein 0.0143 0.0461 0.5372
Onchocerca volvulus 0.0234 0.0792 0.4903
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0131 0.1037
Loa Loa (eye worm) hypothetical protein 0.005 0.0127 0.0256
Brugia malayi beta-lactamase 0.0143 0.0461 0.093
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0076 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0248 0.3101
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0108 0.0852
Brugia malayi Bromodomain containing protein 0.0078 0.0228 0.0459
Echinococcus granulosus Chromobox protein 3 0.0023 0.0028 0.0028
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0108 0.5483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Schistosoma mansoni acetylcholinesterase 0.0234 0.0792 0.0792
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.02 0.1582
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.021 0.021
Toxoplasma gondii ABC1 family protein 0.0143 0.0461 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0053 0.0781
Echinococcus multilocularis expressed protein 0.0067 0.0187 0.0187
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1263 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0054 0.068
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0164 0.0331
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0234 0.0792 0.2283
Onchocerca volvulus 0.0097 0.0298 0.1768
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0103 0.0103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0083 0.0168
Onchocerca volvulus 0.0234 0.0792 0.4903
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0413
Toxoplasma gondii hypothetical protein 0.0059 0.0158 0.3153
Loa Loa (eye worm) hypothetical protein 0.1387 0.4957 1
Schistosoma mansoni rotamase 0.0067 0.0187 0.0187
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Loa Loa (eye worm) hypothetical protein 0.0083 0.0246 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) hypothetical protein 0.0143 0.0461 0.093
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0108 0.0852
Brugia malayi Carboxylesterase family protein 0.0234 0.0792 0.1599
Brugia malayi hypothetical protein 0.0043 0.0103 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Loa Loa (eye worm) hypothetical protein 0.0234 0.0792 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0415
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0799 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) carboxylesterase 0.1387 0.4957 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0019 0.0019
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0042 0.0042
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0234 0.0792 0.0792
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0447 0.5589
Echinococcus multilocularis BC026374 protein (S09 family) 0.0234 0.0792 0.0792
Brugia malayi AMP-binding enzyme family protein 0.0048 0.012 0.0242
Onchocerca volvulus Alhambra homolog 0.0029 0.0051 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.012 0.0616
Leishmania major cathepsin L-like protease 0.002 0.0019 0.0148
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0028 0.1563
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0071 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.0143 0.0461 0.1237
Loa Loa (eye worm) ctsf protein 0.002 0.0019 0.0038
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0385 0.0385
Loa Loa (eye worm) cysteine protease 0.002 0.0019 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0227 0.1317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0519
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0019 0.015
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0112 0.0112
Leishmania major cathepsin L-like protease 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.012 0.0381 0.0768
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0531
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0019 0.5
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0028 0.0203
Loa Loa (eye worm) hypothetical protein 0.0078 0.0227 0.0457
Onchocerca volvulus 0.0457 0.1597 1
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0019 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0033 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0234 0.0792 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Loa Loa (eye worm) fibroinase 0.002 0.0019 0.0038
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0074 0.0074
Echinococcus granulosus chromobox protein 2 0.0023 0.0028 0.0028
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.012 0.0952
Echinococcus granulosus acetylcholinesterase 0.1387 0.4957 0.4957
Trichomonas vaginalis spcc417.12 protein, putative 0.0234 0.0792 0.9916
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0553
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0108 0.0108
Schistosoma mansoni zinc finger protein 0.0031 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Echinococcus multilocularis cysteine protease 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0078 0.0228 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Mycobacterium ulcerans carboxylesterase, LipT 0.0234 0.0792 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Brugia malayi Cathepsin L-like precursor 0.002 0.0019 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0083
Mycobacterium ulcerans hypothetical protein 0.0048 0.012 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0088 0.0088
Onchocerca volvulus 0.0234 0.0792 0.4903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0224 0.1773
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0019 0.0234
Schistosoma mansoni chromobox protein 0.0023 0.0028 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0143 0.0461 0.093
Echinococcus granulosus chromobox protein 1 0.0139 0.0447 0.0447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Loa Loa (eye worm) hypothetical protein 0.0457 0.1597 0.3222
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.012 0.0616
Plasmodium falciparum phd finger protein, putative 0.0029 0.0051 0.5695
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0019 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0028 0.0346
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0028 0.0203
Trichomonas vaginalis rotamase, putative 0.0067 0.0187 0.2334
Brugia malayi hypothetical protein 0.0457 0.1597 0.3222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0019 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.0461 0.5767
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.5175
Loa Loa (eye worm) hypothetical protein 0.0061 0.0166 0.0335
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0028 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0098 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.0461 0.0461
Mycobacterium ulcerans beta-lactamase 0.0143 0.0461 0.5372
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0153
Loa Loa (eye worm) hypothetical protein 0.0097 0.0298 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0108 0.1347
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0187 0.2334
Brugia malayi hypothetical protein 0.0286 0.0977 0.1971
Brugia malayi PHD-finger family protein 0.0051 0.0129 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0028 0.0346
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0028 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0135 0.0135
Schistosoma mansoni chromobox protein 0.0139 0.0447 0.0447
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0181 0.1432
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0076 0.1297
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0075 0.0591
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0028 0.0203
Brugia malayi chromobox protein homolog 3 0.0078 0.0227 0.0457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0224 0.1773
Schistosoma mansoni BC026374 protein (S09 family) 0.0234 0.0792 0.0792
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0224 0.1773
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0049 0.0049
Loa Loa (eye worm) beta-lactamase 0.0143 0.0461 0.093
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0346
Brugia malayi MH2 domain containing protein 0.0144 0.0466 0.0941
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0071 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0103 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0234 0.0792 0.0792
Mycobacterium tuberculosis Probable lipase LipD 0.0143 0.0461 0.1237
Loa Loa (eye worm) carboxylesterase 0.0234 0.0792 0.1599
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0143 0.0461 0.1237
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0066 0.0827
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0977 0.0977
Echinococcus granulosus GPCR family 2 0.0038 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0143 0.0461 0.3649
Mycobacterium ulcerans lipase LipD 0.0143 0.0461 0.5372
Schistosoma mansoni hypothetical protein 0.0043 0.0103 0.0103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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