Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0366 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0366 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0366 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0366 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0 | 0.5 |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0366 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0366 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0366 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0366 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.