Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.3544 | 0.3544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.3544 | 0.5 |
Onchocerca volvulus | 0.0018 | 1 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.3544 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.3544 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.3544 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.3544 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.3544 | 0.3544 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.3544 | 0.3544 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.3544 | 0.3544 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0018 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.3544 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (binding) | = 8.42 | Affinity towards 5-hydroxytryptamine 2 receptor by measuring its ability to antagonize serotonin-induced contractions in the rat jugular vein. | ChEMBL. | 3656357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.