Detailed information for compound 782103

Basic information

Technical information
  • TDR Targets ID: 782103
  • Name: N-(2,4-dimethylphenyl)-7-(2-ethoxyphenyl)-5-m ethyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6 -carboxamide
  • MW: 404.465 | Formula: C22H24N6O2
  • H donors: 2 H acceptors: 4 LogP: 3.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C1C(=C(C)Nc2n1nnn2)C(=O)Nc1ccc(cc1C)C
  • InChi: 1S/C22H24N6O2/c1-5-30-18-9-7-6-8-16(18)20-19(15(4)23-22-25-26-27-28(20)22)21(29)24-17-11-10-13(2)12-14(17)3/h6-12,20H,5H2,1-4H3,(H,24,29)(H,23,25,27)
  • InChiKey: VCDWANJBZJVPHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethylphenyl)-7-(2-ethoxyphenyl)-5-methyl-1,7-dihydro-[1,2,3,4]tetrazolo[1,5-a]pyrimidine-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.1752 0.1752
Echinococcus multilocularis pyruvate kinase 0.0017 0.0519 0.0278
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.4854 0.3192
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.3778 0.5
Echinococcus multilocularis lamin 0.0026 0.2529 0.2339
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.4854 0.4723
Echinococcus multilocularis musashi 0.0026 0.2529 0.2339
Echinococcus granulosus pyruvate kinase 0.0017 0.0519 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.4854 0.4723
Leishmania major DNA polymerase eta, putative 0.0036 0.464 0.1385
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.4854 0.4854
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.4854 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.4854 1
Schistosoma mansoni lamin 0.0026 0.2529 0.2339
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.3778 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Echinococcus granulosus pyruvate kinase 0.0017 0.0519 0.0278
Leishmania major DNA polymerase kappa, putative 0.0037 0.4854 0.173
Echinococcus granulosus pyruvate kinase 0.0017 0.0519 0.0278
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.4854 0.4723
Echinococcus granulosus pyruvate kinase 0.0032 0.3778 0.362
Echinococcus granulosus dna polymerase kappa 0.0037 0.4854 0.4723
Echinococcus granulosus pyruvate kinase 0.0032 0.3778 0.362
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.464 1
Echinococcus multilocularis dna polymerase kappa 0.0037 0.4854 0.4723
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.4854 0.4723
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.1752 0.1752
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.4854 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.3778 0.7908
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.4854 0.173
Leishmania major DNA polymerase eta, putative 0.0062 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.3778 1
Echinococcus granulosus dna polymerase eta 0.0062 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.4854 0.173
Schistosoma mansoni lamin 0.0026 0.2529 0.2339
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.4854 0.3192
Giardia lamblia DINP protein human, muc B family 0.0037 0.4854 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.464 0.1385
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.3778 0.1768
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.4854 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3922 0.3922
Echinococcus multilocularis pyruvate kinase 0.0032 0.3778 0.362
Schistosoma mansoni DNA polymerase eta 0.0062 1 1
Echinococcus multilocularis pyruvate kinase 0.0025 0.2367 0.2173
Loa Loa (eye worm) hypothetical protein 0.0026 0.243 0.243
Echinococcus multilocularis pyruvate kinase 0.0032 0.3778 0.362
Loa Loa (eye worm) hypothetical protein 0.0048 0.7089 0.7089
Echinococcus multilocularis lamin dm0 0.0026 0.2529 0.2339
Schistosoma mansoni pyruvate kinase 0.0032 0.3778 0.362
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0248 0.0248
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.4854 1
Chlamydia trachomatis pyruvate kinase 0.0032 0.3778 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.4854 0.173
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 1 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.3778 0.3778
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.3778 0.3778
Brugia malayi intermediate filament protein 0.0026 0.2529 0.2529
Schistosoma mansoni pyruvate kinase 0.0032 0.3778 0.362
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.4854 1
Trypanosoma brucei DNA polymerase eta, putative 0.0062 1 1
Echinococcus granulosus lamin dm0 0.0026 0.2529 0.2339
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.4854 0.4854
Plasmodium falciparum pyruvate kinase 0.0032 0.3778 1
Giardia lamblia Pyruvate kinase 0.0032 0.3778 0.7518
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.3778 0.3778
Echinococcus multilocularis dna polymerase eta 0.0062 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.3922 0.3768
Schistosoma mansoni intermediate filament proteins 0.0026 0.2529 0.2339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.4854 0.173
Loa Loa (eye worm) pyruvate kinase 0.0032 0.3778 0.3778
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.4854 0.3192
Loa Loa (eye worm) intermediate filament protein 0.0026 0.2529 0.2529
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.2529 0.2529
Loa Loa (eye worm) hypothetical protein 0.0015 0.0248 0.0248
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.7089 0.7089
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.3922 0.3922
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0248 0.0248
Plasmodium vivax pyruvate kinase, putative 0.0032 0.3778 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0519 0.0278
Trypanosoma brucei pyruvate kinase 1 0.0032 0.3778 0.1768
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.4854 0.173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0248 0.0248
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.7089 0.7089
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.3778 1
Echinococcus granulosus lamin 0.0026 0.2529 0.2339
Loa Loa (eye worm) hypothetical protein 0.0026 0.2529 0.2529
Echinococcus multilocularis pyruvate kinase 0.0017 0.0519 0.0278
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.4854 0.3192
Loa Loa (eye worm) hypothetical protein 0.0032 0.3778 0.3778
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.7089 0.7089
Trypanosoma brucei unspecified product 0.0037 0.4854 0.3192
Echinococcus granulosus intermediate filament protein 0.0026 0.2529 0.2339
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.2529 0.2529
Echinococcus multilocularis pyruvate kinase 0.0017 0.0519 0.0278
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.3778 0.3778
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.4854 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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